Next Article in Journal
Alterporriol-Type Dimers from the Mangrove Endophytic Fungus, Alternaria sp. (SK11), and Their MptpB Inhibitions
Next Article in Special Issue
Conotoxins Targeting Nicotinic Acetylcholine Receptors: An Overview
Previous Article in Journal
Echinochrome A Protects Mitochondrial Function in Cardiomyocytes against Cardiotoxic Drugs
Previous Article in Special Issue
Cephalopod Ink: Production, Chemistry, Functions and Applications
Article Menu

Export Article

Open AccessCommunication
Mar. Drugs 2014, 12(5), 2937-2952; doi:10.3390/md12052937

Isolation and Identification of Antitrypanosomal and Antimycobacterial Active Steroids from the Sponge Haliclona simulans

1
Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, The John Arbuthnott Building, 161 Cathedral Street, Glasgow, Scotland G4 0RE, UK
2
Marine Biotechnology Centre, Environmental Research Institute, University College Cork, Lee Road, Cork, Ireland
*
Authors to whom correspondence should be addressed.
Received: 30 January 2014 / Revised: 25 April 2014 / Accepted: 28 April 2014 / Published: 16 May 2014
(This article belongs to the Collection Bioactive Compounds from Marine Invertebrates)
View Full-Text   |   Download PDF [1163 KB, uploaded 24 February 2015]   |  

Abstract

The marine sponge Haliclona simulans collected from the Irish Sea yielded two new steroids: 24-vinyl-cholest-9-ene-3β,24-diol and 20-methyl-pregn-6-en-3β-ol,5a,8a-epidioxy, along with the widely distributed 24-methylenecholesterol. One of the steroids possesses an unusually short hydrocarbon side chain. The structures were elucidated using nuclear magnetic resonance spectroscopy and confirmed using electron impact- and high resolution electrospray-mass spectrometry. All three steroids possess antitrypanosomal and anti-mycobacterial activity. All the steroids were found to possess low cytotoxicity against Hs27 which was above their detected antitrypanosomal potent concentrations. View Full-Text
Keywords: Haliclona simulans; marine sponges; steroids; antitrypanosomal; anti-mycobacterial Haliclona simulans; marine sponges; steroids; antitrypanosomal; anti-mycobacterial
Figures

This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

Supplementary material

Share & Cite This Article

MDPI and ACS Style

Viegelmann, C.; Parker, J.; Ooi, T.; Clements, C.; Abbott, G.; Young, L.; Kennedy, J.; Dobson, A.D.W.; Edrada-Ebel, R. Isolation and Identification of Antitrypanosomal and Antimycobacterial Active Steroids from the Sponge Haliclona simulans. Mar. Drugs 2014, 12, 2937-2952.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Mar. Drugs EISSN 1660-3397 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top