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Open AccessCommunication
Mar. Drugs 2014, 12(5), 2937-2952; doi:10.3390/md12052937

Isolation and Identification of Antitrypanosomal and Antimycobacterial Active Steroids from the Sponge Haliclona simulans

Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, The John Arbuthnott Building, 161 Cathedral Street, Glasgow, Scotland G4 0RE, UK
Marine Biotechnology Centre, Environmental Research Institute, University College Cork, Lee Road, Cork, Ireland
Authors to whom correspondence should be addressed.
Received: 30 January 2014 / Revised: 25 April 2014 / Accepted: 28 April 2014 / Published: 16 May 2014
(This article belongs to the Collection Bioactive Compounds from Marine Invertebrates)
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The marine sponge Haliclona simulans collected from the Irish Sea yielded two new steroids: 24-vinyl-cholest-9-ene-3β,24-diol and 20-methyl-pregn-6-en-3β-ol,5a,8a-epidioxy, along with the widely distributed 24-methylenecholesterol. One of the steroids possesses an unusually short hydrocarbon side chain. The structures were elucidated using nuclear magnetic resonance spectroscopy and confirmed using electron impact- and high resolution electrospray-mass spectrometry. All three steroids possess antitrypanosomal and anti-mycobacterial activity. All the steroids were found to possess low cytotoxicity against Hs27 which was above their detected antitrypanosomal potent concentrations. View Full-Text
Keywords: Haliclona simulans; marine sponges; steroids; antitrypanosomal; anti-mycobacterial Haliclona simulans; marine sponges; steroids; antitrypanosomal; anti-mycobacterial

This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Viegelmann, C.; Parker, J.; Ooi, T.; Clements, C.; Abbott, G.; Young, L.; Kennedy, J.; Dobson, A.D.W.; Edrada-Ebel, R. Isolation and Identification of Antitrypanosomal and Antimycobacterial Active Steroids from the Sponge Haliclona simulans. Mar. Drugs 2014, 12, 2937-2952.

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