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Mar. Drugs 2014, 12(5), 2937-2952; doi:10.3390/md12052937
Communication

Isolation and Identification of Antitrypanosomal and Antimycobacterial Active Steroids from the Sponge Haliclona simulans

1,* , 1
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1
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,
2
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2
 and
1,*
1 Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, The John Arbuthnott Building, 161 Cathedral Street, Glasgow, Scotland G4 0RE, UK 2 Marine Biotechnology Centre, Environmental Research Institute, University College Cork, Lee Road, Cork, Ireland
* Authors to whom correspondence should be addressed.
Received: 30 January 2014 / Revised: 25 April 2014 / Accepted: 28 April 2014 / Published: 16 May 2014
(This article belongs to the collection Bioactive Compounds from Marine Invertebrates)
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Abstract

The marine sponge Haliclona simulans collected from the Irish Sea yielded two new steroids: 24-vinyl-cholest-9-ene-3β,24-diol and 20-methyl-pregn-6-en-3β-ol,5a,8a-epidioxy, along with the widely distributed 24-methylenecholesterol. One of the steroids possesses an unusually short hydrocarbon side chain. The structures were elucidated using nuclear magnetic resonance spectroscopy and confirmed using electron impact- and high resolution electrospray-mass spectrometry. All three steroids possess antitrypanosomal and anti-mycobacterial activity. All the steroids were found to possess low cytotoxicity against Hs27 which was above their detected antitrypanosomal potent concentrations.
Keywords: Haliclona simulans; marine sponges; steroids; antitrypanosomal; anti-mycobacterial Haliclona simulans; marine sponges; steroids; antitrypanosomal; anti-mycobacterial
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Viegelmann, C.; Parker, J.; Ooi, T.; Clements, C.; Abbott, G.; Young, L.; Kennedy, J.; Dobson, A.D.W.; Edrada-Ebel, R. Isolation and Identification of Antitrypanosomal and Antimycobacterial Active Steroids from the Sponge Haliclona simulans. Mar. Drugs 2014, 12, 2937-2952.

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