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Mar. Drugs 2014, 12(5), 2840-2850; doi:10.3390/md12052840
Article

Three New Resveratrol Derivatives from the Mangrove Endophytic Fungus Alternaria sp.

1
, 2
, 1
, 1
, 3
 and 1,*
Received: 31 January 2014; in revised form: 2 March 2014 / Accepted: 22 April 2014 / Published: 13 May 2014
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Abstract: Three new resveratrol derivatives, namely, resveratrodehydes A–C (13), were isolated from the mangrove endophytic fungus Alternaria sp. R6. The structures of these compounds were elucidated by analysis of their MS, 1D and 2D NMR spectroscopic data. All compounds showed broad-spectrum inhibitory activities against three human cancer cell lines including human breast MDA-MB-435, human liver HepG2, and human colon HCT-116 by MTT assay (IC50 < 50 μM). Among them, compounds 1 and 2 both exhibited marked cytotoxic activities against MDA-MB-435 and HCT-116 cell lines (IC50 < 10 μM). Additionally, compounds 1 and 3 showed moderate antioxidant activity by DPPH radical scavenging assay.
Keywords: marine fungus; Alternaria sp.; mangrove; stilbenes; resveratrol; antioxidant; antitumor marine fungus; Alternaria sp.; mangrove; stilbenes; resveratrol; antioxidant; antitumor
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Wang, J.; Cox, D.G.; Ding, W.; Huang, G.; Lin, Y.; Li, C. Three New Resveratrol Derivatives from the Mangrove Endophytic Fungus Alternaria sp.. Mar. Drugs 2014, 12, 2840-2850.

AMA Style

Wang J, Cox DG, Ding W, Huang G, Lin Y, Li C. Three New Resveratrol Derivatives from the Mangrove Endophytic Fungus Alternaria sp.. Marine Drugs. 2014; 12(5):2840-2850.

Chicago/Turabian Style

Wang, Jinhua; Cox, Daniel G.; Ding, Weijia; Huang, Guanghao; Lin, Yongcheng; Li, Chunyuan. 2014. "Three New Resveratrol Derivatives from the Mangrove Endophytic Fungus Alternaria sp.." Mar. Drugs 12, no. 5: 2840-2850.



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