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Mar. Drugs 2014, 12(5), 2840-2850; doi:10.3390/md12052840

Three New Resveratrol Derivatives from the Mangrove Endophytic Fungus Alternaria sp.

1
Institute of Biomaterial, College of Science, South China Agricultural University, Guangzhou 510642, China
2
Department of Pharmacognosy and Research Institute of Pharmaceutical Sciences, School of Pharmacy, Mississippi University, Oxford, MS 38677, USA
3
School of Chemistry and Chemical Engineering, Sun Yat-sen University, 135 Xingang West Road, Guangzhou 510275, China
*
Author to whom correspondence should be addressed.
Received: 31 January 2014 / Revised: 2 March 2014 / Accepted: 22 April 2014 / Published: 13 May 2014
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Abstract

Three new resveratrol derivatives, namely, resveratrodehydes A–C (13), were isolated from the mangrove endophytic fungus Alternaria sp. R6. The structures of these compounds were elucidated by analysis of their MS, 1D and 2D NMR spectroscopic data. All compounds showed broad-spectrum inhibitory activities against three human cancer cell lines including human breast MDA-MB-435, human liver HepG2, and human colon HCT-116 by MTT assay (IC50 < 50 μM). Among them, compounds 1 and 2 both exhibited marked cytotoxic activities against MDA-MB-435 and HCT-116 cell lines (IC50 < 10 μM). Additionally, compounds 1 and 3 showed moderate antioxidant activity by DPPH radical scavenging assay. View Full-Text
Keywords: marine fungus; Alternaria sp.; mangrove; stilbenes; resveratrol; antioxidant; antitumor marine fungus; Alternaria sp.; mangrove; stilbenes; resveratrol; antioxidant; antitumor
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Wang, J.; Cox, D.G.; Ding, W.; Huang, G.; Lin, Y.; Li, C. Three New Resveratrol Derivatives from the Mangrove Endophytic Fungus Alternaria sp.. Mar. Drugs 2014, 12, 2840-2850.

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