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Mar. Drugs 2014, 12(4), 2144-2155; doi:10.3390/md12042144
Communication

Cladieunicellins M–Q, New Eunicellins from Cladiella sp.

1,2,†
, 3,†
, 4
, 1,2
, 2,4
, 2
, 5,6,7,*  and 1,2,6,8,*
Received: 3 March 2014; in revised form: 20 March 2014 / Accepted: 27 March 2014 / Published: 8 April 2014
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Abstract: Five new 7α-hydroxyeunicellin-based diterpenoids, designated as cladieunicellins M–Q (15), were isolated from a Formosan octocoral Cladiella sp. The structures of 15 were elucidated on the basis of spectroscopic methods and by comparison of the data with those of the related metabolites. Cytotoxicity of metabolites 15 against the human leukemia Molt 4 and HL 60 is also described. Among them, compounds 1, 3 and 5 exhibited moderate cytotoxicity toward Molt 4 cells with IC50 values 16.43, 14.17 and 15.55 μM, respectively. Preliminary SAR (structure activity relationship) information was obtained from these compounds and their analogues.
Keywords: eunicellin; Cladiella; cladieunicellin; cytotoxicity eunicellin; Cladiella; cladieunicellin; cytotoxicity
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Chen, T.-H.; Chen, W.-F.; Wen, Z.-H.; Lu, M.-C.; Wang, W.-H.; Li, J.-J.; Wu, Y.-C.; Sung, P.-J. Cladieunicellins M–Q, New Eunicellins from Cladiella sp.. Mar. Drugs 2014, 12, 2144-2155.

AMA Style

Chen T-H, Chen W-F, Wen Z-H, Lu M-C, Wang W-H, Li J-J, Wu Y-C, Sung P-J. Cladieunicellins M–Q, New Eunicellins from Cladiella sp.. Marine Drugs. 2014; 12(4):2144-2155.

Chicago/Turabian Style

Chen, Tsung-Hung; Chen, Wu-Fu; Wen, Zhi-Hong; Lu, Mei-Chin; Wang, Wei-Hsien; Li, Jan-Jung; Wu, Yang-Chang; Sung, Ping-Jyun. 2014. "Cladieunicellins M–Q, New Eunicellins from Cladiella sp.." Mar. Drugs 12, no. 4: 2144-2155.



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