Next Article in Journal
Two New Cytotoxic Indole Alkaloids from a Deep-Sea Sediment Derived Metagenomic Clone
Previous Article in Journal
Action of Clathrodin and Analogues on Voltage-Gated Sodium Channels
Mar. Drugs 2014, 12(4), 2144-2155; doi:10.3390/md12042144

Cladieunicellins M–Q, New Eunicellins from Cladiella sp.

5,6,7,*  and 1,2,6,8,*
1 Graduate Institute of Marine Biotechnology, Department of Life Science and Institute of Biotechnology, National Dong Hwa University, Pingtung 944, Taiwan 2 National Museum of Marine Biology and Aquarium, Pingtung 944, Taiwan 3 Department of Neurosurgery, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung 833, Taiwan 4 Department of Marine Biotechnology and Resources, Asia-Pacific Ocean Research Center, National Sun Yat-sen University, Kaohsiung 804, Taiwan 5 School of Pharmacy, College of Pharmacy, China Medical University, Taichung 404, Taiwan 6 Chinese Medicine Research and Development Center, China Medical University Hospital, Taichung 404, Taiwan 7 Center for Molecular Medicine, China Medical University Hospital, Taichung 404, Taiwan 8 Graduate Institute of Natural Products, Kaohsiung Medical University, Kaohsiung 807, Taiwan These authors contributed equally to this work.
* Authors to whom correspondence should be addressed.
Received: 3 March 2014 / Revised: 20 March 2014 / Accepted: 27 March 2014 / Published: 8 April 2014
View Full-Text   |   Download PDF [690 KB, uploaded 24 February 2015]   |   Browse Figures


Five new 7α-hydroxyeunicellin-based diterpenoids, designated as cladieunicellins M–Q (15), were isolated from a Formosan octocoral Cladiella sp. The structures of 15 were elucidated on the basis of spectroscopic methods and by comparison of the data with those of the related metabolites. Cytotoxicity of metabolites 15 against the human leukemia Molt 4 and HL 60 is also described. Among them, compounds 1, 3 and 5 exhibited moderate cytotoxicity toward Molt 4 cells with IC50 values 16.43, 14.17 and 15.55 μM, respectively. Preliminary SAR (structure activity relationship) information was obtained from these compounds and their analogues.
Keywords: eunicellin; Cladiella; cladieunicellin; cytotoxicity eunicellin; Cladiella; cladieunicellin; cytotoxicity
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Share & Cite This Article

Further Mendeley | CiteULike
Export to BibTeX |
MDPI and ACS Style

Chen, T.-H.; Chen, W.-F.; Wen, Z.-H.; Lu, M.-C.; Wang, W.-H.; Li, J.-J.; Wu, Y.-C.; Sung, P.-J. Cladieunicellins M–Q, New Eunicellins from Cladiella sp.. Mar. Drugs 2014, 12, 2144-2155.

View more citation formats

Related Articles

Article Metrics

For more information on the journal, click here


Cited By

[Return to top]
Mar. Drugs EISSN 1660-3397 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert