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Mar. Drugs 2014, 12(4), 2054-2065; doi:10.3390/md12042054

Placotylene A, an Inhibitor of the Receptor Activator of Nuclear Factor-κB Ligand-Induced Osteoclast Differentiation, from a Korean Sponge Placospongia sp.

2,*  and 1,7,*
1 Center for Marine Natural Products and Drug Discovery, School of Earth and Environmental Sciences, Seoul National University, NS-80, Seoul 151-747, Korea 2 Department of Pharmacy, Sunchon National University, 315 Maegok-dong, Suncheon, Jeollanam-do 540-742, Korea 3 Research Institute of Basic Science, Sunchon National University, Suncheon 540-742, Korea 4 Laboratory of Translational Therapeutics, Pharmacology Research Center, Division of Drug Discovery Research, Korea Research Institute of Chemical Technology, Daejeon 305-600, Korea 5 College of Pharmacy, Yeungnam University, 214-1 Dae-dong, Gyeongsan 712-749, Korea 6 Department of Chemistry and Nano Science, Global Top 5 Program, Ewha Womans University, Seoul 120-750, Korea 7 Research Institute of Oceanography, Seoul National University, NS-80, Seoul 151-747, Korea These authors contributed equally to this work.
* Authors to whom correspondence should be addressed.
Received: 10 February 2014 / Revised: 28 February 2014 / Accepted: 19 March 2014 / Published: 3 April 2014
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A new inhibitor, placotylene A (1), of the receptor activator of nuclear factor-κB ligand (RANKL)-induced osteoclast differentiation, and a regioisomer of placotylene A, placotylene B (2), were isolated from a Korean marine sponge Placospongia sp. The chemical structures of placotylenes A and B were elucidated on the basis of 1D and 2D NMR, along with MS spectral analysis and revealed as an iodinated polyacetylene class of natural products. Placotylene A (1) displayed inhibitory activity against RANKL-induced osteoclast differentiation at 10 μM while placotylene B (2) did not show any significant activity up to 100 μM, respectively.
Keywords: Placospongia; sponge; RANKL; osteoclasts Placospongia; sponge; RANKL; osteoclasts
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Kim, H.; Kim, K.-J.; Yeon, J.-T.; Kim, S.H.; Won, D.H.; Choi, H.; Nam, S.-J.; Son, Y.-J.; Kang, H. Placotylene A, an Inhibitor of the Receptor Activator of Nuclear Factor-κB Ligand-Induced Osteoclast Differentiation, from a Korean Sponge Placospongia sp.. Mar. Drugs 2014, 12, 2054-2065.

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