Next Article in Journal
Phallusiasterols A and B: Two New Sulfated Sterols from the Mediterranean Tunicate Phallusia fumigata and Their Effects as Modulators of the PXR Receptor
Previous Article in Journal
Cyanobacteria from Terrestrial and Marine Sources Contain Apoptogens Able to Overcome Chemoresistance in Acute Myeloid Leukemia Cells
Mar. Drugs 2014, 12(4), 2054-2065; doi:10.3390/md12042054
Article

Placotylene A, an Inhibitor of the Receptor Activator of Nuclear Factor-κB Ligand-Induced Osteoclast Differentiation, from a Korean Sponge Placospongia sp.

1,†
,
2,†
,
3
,
4
,
1
,
5
,
6
,
2,*  and 1,7,*
1 Center for Marine Natural Products and Drug Discovery, School of Earth and Environmental Sciences, Seoul National University, NS-80, Seoul 151-747, Korea 2 Department of Pharmacy, Sunchon National University, 315 Maegok-dong, Suncheon, Jeollanam-do 540-742, Korea 3 Research Institute of Basic Science, Sunchon National University, Suncheon 540-742, Korea 4 Laboratory of Translational Therapeutics, Pharmacology Research Center, Division of Drug Discovery Research, Korea Research Institute of Chemical Technology, Daejeon 305-600, Korea 5 College of Pharmacy, Yeungnam University, 214-1 Dae-dong, Gyeongsan 712-749, Korea 6 Department of Chemistry and Nano Science, Global Top 5 Program, Ewha Womans University, Seoul 120-750, Korea 7 Research Institute of Oceanography, Seoul National University, NS-80, Seoul 151-747, Korea These authors contributed equally to this work.
* Authors to whom correspondence should be addressed.
Received: 10 February 2014 / Revised: 28 February 2014 / Accepted: 19 March 2014 / Published: 3 April 2014
View Full-Text   |   Download PDF [979 KB, uploaded 24 February 2015]   |   Browse Figures

Abstract

A new inhibitor, placotylene A (1), of the receptor activator of nuclear factor-κB ligand (RANKL)-induced osteoclast differentiation, and a regioisomer of placotylene A, placotylene B (2), were isolated from a Korean marine sponge Placospongia sp. The chemical structures of placotylenes A and B were elucidated on the basis of 1D and 2D NMR, along with MS spectral analysis and revealed as an iodinated polyacetylene class of natural products. Placotylene A (1) displayed inhibitory activity against RANKL-induced osteoclast differentiation at 10 μM while placotylene B (2) did not show any significant activity up to 100 μM, respectively.
Keywords: Placospongia; sponge; RANKL; osteoclasts Placospongia; sponge; RANKL; osteoclasts
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Supplement

Share & Cite This Article

Further Mendeley | CiteULike
Export to BibTeX |
EndNote
MDPI and ACS Style

Kim, H.; Kim, K.-J.; Yeon, J.-T.; Kim, S.H.; Won, D.H.; Choi, H.; Nam, S.-J.; Son, Y.-J.; Kang, H. Placotylene A, an Inhibitor of the Receptor Activator of Nuclear Factor-κB Ligand-Induced Osteoclast Differentiation, from a Korean Sponge Placospongia sp.. Mar. Drugs 2014, 12, 2054-2065.

View more citation formats

Related Articles

Article Metrics

For more information on the journal, click here

Comments

Cited By

[Return to top]
Mar. Drugs EISSN 1660-3397 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert