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Mar. Drugs 2014, 12(3), 1271-1280; doi:10.3390/md12031271

Spirobisnaphthalenes from the Mangrove-Derived Fungus Rhytidhysteron sp. AS21B

1,* , 1
1 Department of Chemistry, Faculty of Science, Chulalongkorn University, Bangkok 10330, Thailand 2 Program in Biotechnology, Faculty of Science, Chulalongkorn Universtiy, Bangkok 10330, Thailand
* Author to whom correspondence should be addressed.
Received: 6 January 2014 / Revised: 8 February 2014 / Accepted: 18 February 2014 / Published: 6 March 2014
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Three new spirobisnaphthalenes (13) were isolated from the mangrove-derived fungus Rhytidhysteron sp., together with five known derivatives (48). The structures of the compounds were established on the basis of extensive spectroscopic data, and the relative configurations of their stereogenic carbons were determined by a single-crystal X-ray crystallographic analysis. Compounds 35 displayed cytotoxicity against both cancer cell lines, MCF-7 and CaSki, while 2 was active only on CaSKi cells.
Keywords: endophytic fungus; Rhytidhysteron sp.; spirobisnaphthalene; cytotoxicity endophytic fungus; Rhytidhysteron sp.; spirobisnaphthalene; cytotoxicity
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Pudhom, K.; Teerawatananond, T.; Chookpaiboon, S. Spirobisnaphthalenes from the Mangrove-Derived Fungus Rhytidhysteron sp. AS21B. Mar. Drugs 2014, 12, 1271-1280.

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