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Mar. Drugs 2014, 12(2), 822-839; doi:10.3390/md12020822
Article

Antibacterial and Antibiofilm Activities of Tryptoquivalines and Meroditerpenes Isolated from the Marine-Derived Fungi Neosartorya paulistensis, N. laciniosa, N. tsunodae, and the Soil Fungi N. fischeri and N. siamensis

1,2,†
,
1,2,†
,
1,2
,
1,2
,
3
,
4
,
5
 and
1,2,*
1 ICBAS—Instituto de Ciências Biomédicas de Abel Salazar, Rua de Jorge Viterbo Ferreira, 228, Porto 4050-313, Portugal 2 Interdisciplinary Centre of Marine and Environmental Research (CIIMAR), Universidade do Porto, Rua dos Bragas 289, Porto 4050-123, Portugal 3 Division of Environmental Science, Faculty of Science, Ramkhamhaeng University, Bangkok 10240, Thailand 4 Department of Plant Pathology, Faculty of Agriculture, Kasetsart University, Bangkok 10240, Thailand 5 Departamento de Química, Universidade de Aveiro, Aveiro 4810-1933, Portugal These authors contributed equally to this work.
* Author to whom correspondence should be addressed.
Received: 25 December 2013 / Revised: 17 January 2014 / Accepted: 20 January 2014 / Published: 28 January 2014
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Abstract

A new meroditerpene, sartorypyrone C (5), was isolated, together with the known tryptoquivalines L (1a), H (1b), F (1c), 3′-(4-oxoquinazolin-3-yl) spiro [1H-indole-3,5′]-2,2′-dione (2) and 4(3H)-quinazolinone (3), from the culture of the marine sponge-associated fungus Neosartorya paulistensis (KUFC 7897), while reexamination of the fractions remaining from a previous study of the culture of the diseased coral-derived fungus N. laciniosa (KUFC 7896) led to isolation of a new tryptoquivaline derivative tryptoquivaline T (1d). Compounds 1ad, 2, 3, and 5, together with aszonapyrones A (4a) and B (4b), chevalones B (6) and C (7a), sartorypyrones B (7b) and A (8), were tested for their antibacterial activity against four reference strains (Staphylococcus aureus, Bacillus subtilis, Escherichia coli, and Pseudomonas aeruginosa), as well as the environmental multidrug-resistant isolates. Only aszonapyrone A (4a) and sartorypyrone A (8) exhibited significant antibacterial activity as well as synergism with antibiotics against the Gram-positive multidrug-resistant strains. Antibiofilm assays of aszonapyrone A (4a) and sartorypyrone A (8) showed that practically no biofilm was formed in the presence of their 2× MIC and MIC. However, the presence of a sub-inhibitory concentration of ½ MIC of 4a and 8 was found to increase the biofilm production in both reference strain and the multidrug-resistant isolates of S. aureus.
Keywords: antibacterial; antibiofilm; multidrug-resistant; tryptoquivalines; meroditerpenes; Neosartorya; marine-derived fungi antibacterial; antibiofilm; multidrug-resistant; tryptoquivalines; meroditerpenes; Neosartorya; marine-derived fungi
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Gomes, N.M.; Bessa, L.J.; Buttachon, S.; Costa, P.M.; Buaruang, J.; Dethoup, T.; Silva, A.M.S.; Kijjoa, A. Antibacterial and Antibiofilm Activities of Tryptoquivalines and Meroditerpenes Isolated from the Marine-Derived Fungi Neosartorya paulistensis, N. laciniosa, N. tsunodae, and the Soil Fungi N. fischeri and N. siamensis. Mar. Drugs 2014, 12, 822-839.

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