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Mar. Drugs 2014, 12(12), 5993-6002; doi:10.3390/md12125993

Three New Asperentin Derivatives from the Algicolous Fungus Aspergillus sp. F00785

1
State Key Laboratory of Cellular Stress Biology, School of Life Sciences, Xiamen University, Xiamen, Fujian 361102, China
2
State-Province Joint Engineering Laboratory of Targeted Drugs from Natural Products, Xiamen University, Xiamen, Fujian 361102, China
3
State Key Laboratory for Physical Chemistry of Solid Surface, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen, Fujian 361005, China
*
Authors to whom correspondence should be addressed.
Received: 21 October 2014 / Revised: 21 November 2014 / Accepted: 4 December 2014 / Published: 15 December 2014
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Abstract

Three new asperentin-type compounds, 6-O-α-d-ribosylasperentin (1) and 6-O-α-d-ribosyl-8-O-methylasperentin (2) and 5-hydroxyl-6-O-methylasperentin (3), along with asperentin (4) and its known analogues (59), were isolated from a halotolerant Aspergillus sp. strain F00785, an endotrophic fungus from marine alga. Their structures were determined using extensive NMR and HRESIMS spectroscopic analysis, including the X-ray crystallographic data for the assignment of the absolute configurations of compound 9. Compound 4 exhibited highly potent inhibitory activity against crop pathogens, Colletotrichum gleosporioides Penz. and Colletotrichum gleosporioides (Penz.) Sacc. View Full-Text
Keywords: asperentin; endophytic fungus; crop pathogen; α-d-ribofuranose asperentin; endophytic fungus; crop pathogen; α-d-ribofuranose
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Tang, Q.; Guo, K.; Li, X.-Y.; Zheng, X.-Y.; Kong, X.-J.; Zheng, Z.-H.; Xu, Q.-Y.; Deng, X. Three New Asperentin Derivatives from the Algicolous Fungus Aspergillus sp. F00785. Mar. Drugs 2014, 12, 5993-6002.

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