Mar. Drugs 2014, 12(1), 525-546; doi:10.3390/md12010525

Marine Natural Products with P-Glycoprotein Inhibitor Properties

1,2email and 1,* email
Received: 22 November 2013; in revised form: 6 January 2014 / Accepted: 7 January 2014 / Published: 22 January 2014
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: P-glycoprotein (P-gp) is a protein belonging to the ATP-binding cassette (ABC) transporters superfamily that has clinical relevance due to its role in drug metabolism and multi-drug resistance (MDR) in several human pathogens and diseases. P-gp is a major cause of drug resistance in cancer, parasitic diseases, epilepsy and other disorders. This review article aims to summarize the research findings on the marine natural products with P-glycoprotein inhibitor properties. Natural compounds that modulate P-gp offer great possibilities for semi-synthetic modification to create new drugs and are valuable research tools to understand the function of complex ABC transporters.
Keywords: P-glycoprotein; marine natural products; multidrug resistance
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MDPI and ACS Style

Lopez, D.; Martinez-Luis, S. Marine Natural Products with P-Glycoprotein Inhibitor Properties. Mar. Drugs 2014, 12, 525-546.

AMA Style

Lopez D, Martinez-Luis S. Marine Natural Products with P-Glycoprotein Inhibitor Properties. Marine Drugs. 2014; 12(1):525-546.

Chicago/Turabian Style

Lopez, Dioxelis; Martinez-Luis, Sergio. 2014. "Marine Natural Products with P-Glycoprotein Inhibitor Properties." Mar. Drugs 12, no. 1: 525-546.

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