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Mar. Drugs 2014, 12(1), 525-546; doi:10.3390/md12010525
Review

Marine Natural Products with P-Glycoprotein Inhibitor Properties

1,2
 and
1,*
Received: 22 November 2013 / Revised: 6 January 2014 / Accepted: 7 January 2014 / Published: 22 January 2014
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Abstract

P-glycoprotein (P-gp) is a protein belonging to the ATP-binding cassette (ABC) transporters superfamily that has clinical relevance due to its role in drug metabolism and multi-drug resistance (MDR) in several human pathogens and diseases. P-gp is a major cause of drug resistance in cancer, parasitic diseases, epilepsy and other disorders. This review article aims to summarize the research findings on the marine natural products with P-glycoprotein inhibitor properties. Natural compounds that modulate P-gp offer great possibilities for semi-synthetic modification to create new drugs and are valuable research tools to understand the function of complex ABC transporters.
Keywords: P-glycoprotein; marine natural products; multidrug resistance P-glycoprotein; marine natural products; multidrug resistance
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Lopez, D.; Martinez-Luis, S. Marine Natural Products with P-Glycoprotein Inhibitor Properties. Mar. Drugs 2014, 12, 525-546.

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