Marine Natural Products with P-Glycoprotein Inhibitor Properties
AbstractP-glycoprotein (P-gp) is a protein belonging to the ATP-binding cassette (ABC) transporters superfamily that has clinical relevance due to its role in drug metabolism and multi-drug resistance (MDR) in several human pathogens and diseases. P-gp is a major cause of drug resistance in cancer, parasitic diseases, epilepsy and other disorders. This review article aims to summarize the research findings on the marine natural products with P-glycoprotein inhibitor properties. Natural compounds that modulate P-gp offer great possibilities for semi-synthetic modification to create new drugs and are valuable research tools to understand the function of complex ABC transporters.
Scifeed alert for new publicationsNever miss any articles matching your research from any publisher
- Get alerts for new papers matching your research
- Find out the new papers from selected authors
- Updated daily for 49'000+ journals and 6000+ publishers
- Define your Scifeed now
Lopez, D.; Martinez-Luis, S. Marine Natural Products with P-Glycoprotein Inhibitor Properties. Mar. Drugs 2014, 12, 525-546.
Lopez D, Martinez-Luis S. Marine Natural Products with P-Glycoprotein Inhibitor Properties. Marine Drugs. 2014; 12(1):525-546.Chicago/Turabian Style
Lopez, Dioxelis; Martinez-Luis, Sergio. 2014. "Marine Natural Products with P-Glycoprotein Inhibitor Properties." Mar. Drugs 12, no. 1: 525-546.