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Mar. Drugs 2014, 12(1), 36-53; doi:10.3390/md12010036
Article

Solomonsterol A, a Marine Pregnane-X-Receptor Agonist, Attenuates Inflammation and Immune Dysfunction in a Mouse Model of Arthritis

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Received: 21 October 2013; in revised form: 6 December 2013 / Accepted: 9 December 2013 / Published: 24 December 2013
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Abstract: In the present study we provide evidence that solomonsterol A, a selective pregnane X receptor (PXR) agonist isolated from the marine sponge Theonella swinhoei, exerts anti-inflammatory activity and attenuates systemic inflammation and immune dysfunction in a mouse model of rheumatoid arthritis. Solomonsterol A was effective in protecting against the development of arthritis induced by injecting transgenic mice harboring a humanized PXR, with anti-collagen antibodies (CAIA) with beneficial effects on joint histopathology and local inflammatory response reducing the expression of inflammatory markers (TNFα, IFNγ and IL-17 and chemokines MIP1α and RANTES) in draining lymph nodes. Solomonsterol A rescued mice from systemic inflammation were assessed by measuring arthritis score, CRP and cytokines in the blood. In summary, the present study provides a molecular basis for the regulation of systemic local and systemic immunity by PXR agonists.
Keywords: marine sponge; Theonella swinhoei; rheumatoid arthritis; inflammation; pregnane X receptor (PXR); solomonsterol A marine sponge; Theonella swinhoei; rheumatoid arthritis; inflammation; pregnane X receptor (PXR); solomonsterol A
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Mencarelli, A.; D'Amore, C.; Renga, B.; Cipriani, S.; Carino, A.; Sepe, V.; Perissutti, E.; D'Auria, M.V.; Zampella, A.; Distrutti, E.; Fiorucci, S. Solomonsterol A, a Marine Pregnane-X-Receptor Agonist, Attenuates Inflammation and Immune Dysfunction in a Mouse Model of Arthritis. Mar. Drugs 2014, 12, 36-53.

AMA Style

Mencarelli A, D'Amore C, Renga B, Cipriani S, Carino A, Sepe V, Perissutti E, D'Auria MV, Zampella A, Distrutti E, Fiorucci S. Solomonsterol A, a Marine Pregnane-X-Receptor Agonist, Attenuates Inflammation and Immune Dysfunction in a Mouse Model of Arthritis. Marine Drugs. 2014; 12(1):36-53.

Chicago/Turabian Style

Mencarelli, Andrea; D'Amore, Claudio; Renga, Barbara; Cipriani, Sabrina; Carino, Adriana; Sepe, Valentina; Perissutti, Elisa; D'Auria, Maria V.; Zampella, Angela; Distrutti, Eleonora; Fiorucci, Stefano. 2014. "Solomonsterol A, a Marine Pregnane-X-Receptor Agonist, Attenuates Inflammation and Immune Dysfunction in a Mouse Model of Arthritis." Mar. Drugs 12, no. 1: 36-53.


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