Mar. Drugs 2014, 12(1), 167-175; doi:10.3390/md12010167
Communication

Induced Marine Fungus Chondrostereum sp. as a Means of Producing New Sesquiterpenoids Chondrosterins I and J by Using Glycerol as the Carbon Source

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Received: 1 November 2013; in revised form: 2 December 2013 / Accepted: 12 December 2013 / Published: 7 January 2014
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: Chondrostereum sp., a marine fungus isolated from a soft coral Sarcophyton tortuosum, can yield hirsutane framework sesquiterpenoids. However, the metabolites profiles vary dramatically with the composition change of the culture media. This fungus was cultured in a liquid medium containing glycerol as the carbon source, and two new metabolites, chondrosterins I and J (1 and 2), were obtained. Their structures were elucidated primarily based on MS, NMR and X-ray single-crystal diffraction data. By comparison with the known hirsutane sesquiterpenoids, chondrosterins I and J have unique structural features, including a methyl was migrated from C-2 to C-6, and the methyl at C-3 was carboxylated. Compound 2 exhibited potent cytotoxic activities against the cancer cell lines CNE-1 and CNE-2 with the IC50 values of 1.32 and 0.56 μM.
Keywords: marine fungus; Chondrostereum sp.; sesquiterpenoids; chondrosterins; cytotoxic activity
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MDPI and ACS Style

Li, H.-J.; Jiang, W.-H.; Liang, W.-L.; Huang, J.-X.; Mo, Y.-F.; Ding, Y.-Q.; Lam, C.-K.; Qian, X.-J.; Zhu, X.-F.; Lan, W.-J. Induced Marine Fungus Chondrostereum sp. as a Means of Producing New Sesquiterpenoids Chondrosterins I and J by Using Glycerol as the Carbon Source. Mar. Drugs 2014, 12, 167-175.

AMA Style

Li H-J, Jiang W-H, Liang W-L, Huang J-X, Mo Y-F, Ding Y-Q, Lam C-K, Qian X-J, Zhu X-F, Lan W-J. Induced Marine Fungus Chondrostereum sp. as a Means of Producing New Sesquiterpenoids Chondrosterins I and J by Using Glycerol as the Carbon Source. Marine Drugs. 2014; 12(1):167-175.

Chicago/Turabian Style

Li, Hou-Jin; Jiang, Wen-Han; Liang, Wan-Ling; Huang, Jia-Xin; Mo, Yu-Fei; Ding, Yan-Qing; Lam, Chi-Keung; Qian, Xiao-Jun; Zhu, Xiao-Feng; Lan, Wen-Jian. 2014. "Induced Marine Fungus Chondrostereum sp. as a Means of Producing New Sesquiterpenoids Chondrosterins I and J by Using Glycerol as the Carbon Source." Mar. Drugs 12, no. 1: 167-175.

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