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Mar. Drugs 2014, 12(1), 167-175; doi:10.3390/md12010167
Communication

Induced Marine Fungus Chondrostereum sp. as a Means of Producing New Sesquiterpenoids Chondrosterins I and J by Using Glycerol as the Carbon Source

1
, 1
, 2
, 1
, 2
, 2
, 1
, 3
, 3
 and 2,4,*
1 School of Chemistry and Chemical Engineering, Sun Yat-Sen University, Guangzhou 510275, China 2 School of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou 510006, China 3 State Key Laboratory of Oncology in South China, Cancer Center, Sun Yat-Sen University, Guangzhou 510060, China 4 Guangdong Technology Research Center for Advanced Chinese Medicine, Guangzhou 510006, China
* Author to whom correspondence should be addressed.
Received: 1 November 2013 / Revised: 2 December 2013 / Accepted: 12 December 2013 / Published: 7 January 2014
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Abstract

Chondrostereum sp., a marine fungus isolated from a soft coral Sarcophyton tortuosum, can yield hirsutane framework sesquiterpenoids. However, the metabolites profiles vary dramatically with the composition change of the culture media. This fungus was cultured in a liquid medium containing glycerol as the carbon source, and two new metabolites, chondrosterins I and J (1 and 2), were obtained. Their structures were elucidated primarily based on MS, NMR and X-ray single-crystal diffraction data. By comparison with the known hirsutane sesquiterpenoids, chondrosterins I and J have unique structural features, including a methyl was migrated from C-2 to C-6, and the methyl at C-3 was carboxylated. Compound 2 exhibited potent cytotoxic activities against the cancer cell lines CNE-1 and CNE-2 with the IC50 values of 1.32 and 0.56 μM.
Keywords: marine fungus; Chondrostereum sp.; sesquiterpenoids; chondrosterins; cytotoxic activity marine fungus; Chondrostereum sp.; sesquiterpenoids; chondrosterins; cytotoxic activity
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Li, H.-J.; Jiang, W.-H.; Liang, W.-L.; Huang, J.-X.; Mo, Y.-F.; Ding, Y.-Q.; Lam, C.-K.; Qian, X.-J.; Zhu, X.-F.; Lan, W.-J. Induced Marine Fungus Chondrostereum sp. as a Means of Producing New Sesquiterpenoids Chondrosterins I and J by Using Glycerol as the Carbon Source. Mar. Drugs 2014, 12, 167-175.

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