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Mar. Drugs 2013, 11(9), 3288-3296; doi:10.3390/md11093288
Article

Secosteroids and Norcembranoids from the Soft Coral Sinularia nanolobata

1
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2,3,*  and 1,3,*
Received: 25 July 2013 / Revised: 15 August 2013 / Accepted: 21 August 2013 / Published: 27 August 2013
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Abstract

Two new 9,11-secosteroids, 22α-acetoxy-24-methylene-3β,6α,11-trihydroxy-9, 11-seco-cholest-7-en-9-one (1) and 11-acetoxy-24-methylene-1β,3β,6α-trihydroxy-9, 11-seco-cholest-7-en-9-one (2), as well as two known norcembranoids, 5-epi-sinuleptolide (3) and sinuleptolide (4), were isolated from the soft coral Sinularia nanolobata. The structures of these metabolites were elucidated on the basis of extensive spectroscopic analysis. The anti-HCMV (human cytomegalovirus) activity of 14 and its cytotoxicity against selected cell lines were evaluated.
Keywords: soft coral; Sinularia nanolobata; secosteroid; cytotoxicity soft coral; Sinularia nanolobata; secosteroid; cytotoxicity
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Tseng, Y.-J.; Wang, S.-K.; Duh, C.-Y. Secosteroids and Norcembranoids from the Soft Coral Sinularia nanolobata. Mar. Drugs 2013, 11, 3288-3296.

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