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Mar. Drugs 2013, 11(9), 3288-3296; doi:10.3390/md11093288
Article

Secosteroids and Norcembranoids from the Soft Coral Sinularia nanolobata

1
,
2,3,*  and 1,3,*
1 Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung 804, Taiwan 2 Department of Microbiology, Kaohsiung Medical University, Kaohsiung 807, Taiwan 3 Asia-Pacific Ocean Research Center, National Sun Yat-sen University, Kaohsiung 804, Taiwan
* Authors to whom correspondence should be addressed.
Received: 25 July 2013 / Revised: 15 August 2013 / Accepted: 21 August 2013 / Published: 27 August 2013
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Abstract

Two new 9,11-secosteroids, 22α-acetoxy-24-methylene-3β,6α,11-trihydroxy-9, 11-seco-cholest-7-en-9-one (1) and 11-acetoxy-24-methylene-1β,3β,6α-trihydroxy-9, 11-seco-cholest-7-en-9-one (2), as well as two known norcembranoids, 5-epi-sinuleptolide (3) and sinuleptolide (4), were isolated from the soft coral Sinularia nanolobata. The structures of these metabolites were elucidated on the basis of extensive spectroscopic analysis. The anti-HCMV (human cytomegalovirus) activity of 14 and its cytotoxicity against selected cell lines were evaluated.
Keywords: soft coral; Sinularia nanolobata; secosteroid; cytotoxicity soft coral; Sinularia nanolobata; secosteroid; cytotoxicity
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Tseng, Y.-J.; Wang, S.-K.; Duh, C.-Y. Secosteroids and Norcembranoids from the Soft Coral Sinularia nanolobata. Mar. Drugs 2013, 11, 3288-3296.

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