Next Article in Journal
Double Strand Breaks and Cell-Cycle Arrest Induced by the Cyanobacterial Toxin Cylindrospermopsin in HepG2 Cells
Next Article in Special Issue
Towards the Small and the Beautiful: A Small Dibromotyrosine Derivative from Pseudoceratina sp. Sponge Exhibits Potent Apoptotic Effect through Targeting IKK/NFκB Signaling Pathway
Previous Article in Journal
An Aeroplysinin-1 Specific Nitrile Hydratase Isolated from the Marine Sponge Aplysina cavernicola
Previous Article in Special Issue
Proteomic Investigation of the Sinulariolide-Treated Melanoma Cells A375: Effects on the Cell Apoptosis through Mitochondrial-Related Pathway and Activation of Caspase Cascade
Mar. Drugs 2013, 11(8), 3068-3076; doi:10.3390/md11083068
Article

Cytotoxic Anthranilic Acid Derivatives from Deep Sea Sediment-Derived Fungus Penicillium paneum SD-44

1
,
1
,
1
,
2
 and
1,*
1 Key Laboratory of Experimental Marine Biology, Institute of Oceanology, Chinese Academy of Sciences, Nanhai Road 7, Qingdao 266071, China 2 State Key Laboratory of Bioreactor Engineering, East China University of Science & Technology, Shanghai 200237, China
* Author to whom correspondence should be addressed.
Received: 4 June 2013 / Revised: 9 July 2013 / Accepted: 30 July 2013 / Published: 21 August 2013
(This article belongs to the Special Issue Marine Compounds and Cancer)
View Full-Text   |   Download PDF [413 KB, uploaded 24 February 2015]   |  

Abstract

Five new anthranilic acid derivatives, penipacids A–E (15), together with one known analogue (6), which was previously synthesized, were characterized from the ethyl acetate extract of the marine sediment-derived fungus Penicillium paneum SD-44. Their structures were elucidated mainly by extensive NMR spectroscopic and mass spectrometric analysis. The cytotoxicity and antimicrobial activity of the isolated compounds were evaluated. Compounds 1, and 5 exhibited inhibitory activity against human colon cancer RKO cell line, while compound 6 displayed cytotoxic activity against Hela cell line.
Keywords: marine fungus; sediment; anthranilic acid; Penicillium paneum; cytotoxicity marine fungus; sediment; anthranilic acid; Penicillium paneum; cytotoxicity
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

Supplementary materials

SciFeed

Share & Cite This Article

Further Mendeley | CiteULike
Export to BibTeX |
EndNote |
RIS
MDPI and ACS Style

Li, C.-S.; Li, X.-M.; Gao, S.-S.; Lu, Y.-H.; Wang, B.-G. Cytotoxic Anthranilic Acid Derivatives from Deep Sea Sediment-Derived Fungus Penicillium paneum SD-44. Mar. Drugs 2013, 11, 3068-3076.

View more citation formats

Related Articles

Article Metrics

For more information on the journal, click here

Comments

[Return to top]
Mar. Drugs EISSN 1660-3397 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert