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Mar. Drugs 2013, 11(8), 3068-3076; doi:10.3390/md11083068

Cytotoxic Anthranilic Acid Derivatives from Deep Sea Sediment-Derived Fungus Penicillium paneum SD-44

Key Laboratory of Experimental Marine Biology, Institute of Oceanology, Chinese Academy of Sciences, Nanhai Road 7, Qingdao 266071, China
State Key Laboratory of Bioreactor Engineering, East China University of Science & Technology, Shanghai 200237, China
Author to whom correspondence should be addressed.
Received: 4 June 2013 / Revised: 9 July 2013 / Accepted: 30 July 2013 / Published: 21 August 2013
(This article belongs to the Collection Marine Compounds and Cancer)
View Full-Text   |   Download PDF [413 KB, uploaded 24 February 2015]   |  


Five new anthranilic acid derivatives, penipacids A–E (15), together with one known analogue (6), which was previously synthesized, were characterized from the ethyl acetate extract of the marine sediment-derived fungus Penicillium paneum SD-44. Their structures were elucidated mainly by extensive NMR spectroscopic and mass spectrometric analysis. The cytotoxicity and antimicrobial activity of the isolated compounds were evaluated. Compounds 1, and 5 exhibited inhibitory activity against human colon cancer RKO cell line, while compound 6 displayed cytotoxic activity against Hela cell line. View Full-Text
Keywords: marine fungus; sediment; anthranilic acid; Penicillium paneum; cytotoxicity marine fungus; sediment; anthranilic acid; Penicillium paneum; cytotoxicity

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This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Li, C.-S.; Li, X.-M.; Gao, S.-S.; Lu, Y.-H.; Wang, B.-G. Cytotoxic Anthranilic Acid Derivatives from Deep Sea Sediment-Derived Fungus Penicillium paneum SD-44. Mar. Drugs 2013, 11, 3068-3076.

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