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Mar. Drugs 2013, 11(8), 3068-3076; doi:10.3390/md11083068
Article

Cytotoxic Anthranilic Acid Derivatives from Deep Sea Sediment-Derived Fungus Penicillium paneum SD-44

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Received: 4 June 2013; in revised form: 9 July 2013 / Accepted: 30 July 2013 / Published: 21 August 2013
(This article belongs to the Special Issue Marine Compounds and Cancer)
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Abstract: Five new anthranilic acid derivatives, penipacids A–E (15), together with one known analogue (6), which was previously synthesized, were characterized from the ethyl acetate extract of the marine sediment-derived fungus Penicillium paneum SD-44. Their structures were elucidated mainly by extensive NMR spectroscopic and mass spectrometric analysis. The cytotoxicity and antimicrobial activity of the isolated compounds were evaluated. Compounds 1, and 5 exhibited inhibitory activity against human colon cancer RKO cell line, while compound 6 displayed cytotoxic activity against Hela cell line.
Keywords: marine fungus; sediment; anthranilic acid; Penicillium paneum; cytotoxicity marine fungus; sediment; anthranilic acid; Penicillium paneum; cytotoxicity
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Li, C.-S.; Li, X.-M.; Gao, S.-S.; Lu, Y.-H.; Wang, B.-G. Cytotoxic Anthranilic Acid Derivatives from Deep Sea Sediment-Derived Fungus Penicillium paneum SD-44. Mar. Drugs 2013, 11, 3068-3076.

AMA Style

Li C-S, Li X-M, Gao S-S, Lu Y-H, Wang B-G. Cytotoxic Anthranilic Acid Derivatives from Deep Sea Sediment-Derived Fungus Penicillium paneum SD-44. Marine Drugs. 2013; 11(8):3068-3076.

Chicago/Turabian Style

Li, Chun-Shun; Li, Xiao-Ming; Gao, Shu-Shan; Lu, Yan-Hua; Wang, Bin-Gui. 2013. "Cytotoxic Anthranilic Acid Derivatives from Deep Sea Sediment-Derived Fungus Penicillium paneum SD-44." Mar. Drugs 11, no. 8: 3068-3076.


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