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Mar. Drugs 2013, 11(8), 2769-2784; doi:10.3390/md11082769
Article

Cellular Antioxidant Effect of Four Bromophenols from the Red Algae, Vertebrata lanosa

1,* , 2
,
3
 and
2
Received: 3 May 2013 / Revised: 14 June 2013 / Accepted: 12 July 2013 / Published: 5 August 2013
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Abstract

Three known bromophenols, 2,3-dibromo-4,5-dihydroxybenzylaldehyde (1), 2,2′,3-tribromo-3′,4,4′,5-tetrahydroxy-6′-hydroxymethyldiphenylmethane (2) and bis(2, 3-dibromo-4,5-dihydroxylbenzyl) ether (3), and one new one, 5,5″-oxybis(methylene)bis (3-bromo-4-(2′,3′-dibromo-4′,5′-dihydroxylbenzyl)benzene-1,2-diol) (4), were isolated from an extract of the red alga, Vertebrata lanosa. The antioxidant activity of these four bromophenols was examined using one biochemical and two cellular assays: Oxygen Radical Absorbance Capacity (ORAC), Cellular Antioxidant Activity (CAA) and Cellular Lipid Peroxidation Antioxidant Activity (CLPAA) assays. Compound 2 distinguished itself by showing potent activity, having a better antioxidant effect than luteolin in both the CAA and CLPAA assays and of quercetin in the CLPAA assay. Although several bromophenols are known to be potent antioxidants in biochemical assays, this is the first time their cellular antioxidant activity has been demonstrated.
Keywords: marine algae; macro algae; bioactivity; cellular antioxidant assay; ORAC marine algae; macro algae; bioactivity; cellular antioxidant assay; ORAC
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Olsen, E.K.; Hansen, E.; Isaksson, J.; Andersen, J.H. Cellular Antioxidant Effect of Four Bromophenols from the Red Algae, Vertebrata lanosa. Mar. Drugs 2013, 11, 2769-2784.

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