Cembrane Derivatives from the Soft Corals, Sinularia gaweli and Sinularia flexibilis
AbstractA new norcembranoidal diterpene, 1-epi-sinulanorcembranolide A (1), and a new cembranoidal diterpene, flexibilin D (2), were isolated from the soft corals, Sinularia gaweli and Sinularia flexibilis, respectively. The structures of new metabolites 1 and 2 were elucidated by spectroscopic methods, and compound 2 was found to significantly inhibit the accumulation of the pro-inflammatory iNOS and COX-2 proteins of the lipopolysaccharide (LPS)-stimulated RAW264.7 macrophage cells. In addition, S. flexibilis yielded a known cembrane, 5-dehydrosinulariolide (3); the structure, including its absolute stereochemistry, was further confirmed by single-crystal X-ray diffraction analysis.
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Hu, L.-C.; Yen, W.-H.; Su, J.-H.; Chiang, M.Y.-N.; Wen, Z.-H.; Chen, W.-F.; Lu, T.-J.; Chang, Y.-W.; Chen, Y.-H.; Wang, W.-H.; Wu, Y.-C.; Sung, P.-J. Cembrane Derivatives from the Soft Corals, Sinularia gaweli and Sinularia flexibilis. Mar. Drugs 2013, 11, 2154-2167.
Hu L-C, Yen W-H, Su J-H, Chiang MY-N, Wen Z-H, Chen W-F, Lu T-J, Chang Y-W, Chen Y-H, Wang W-H, Wu Y-C, Sung P-J. Cembrane Derivatives from the Soft Corals, Sinularia gaweli and Sinularia flexibilis. Marine Drugs. 2013; 11(6):2154-2167.Chicago/Turabian Style
Hu, Li-Chung; Yen, Wei-Hsuan; Su, Jui-Hsin; Chiang, Michael Y.-N.; Wen, Zhi-Hong; Chen, Wu-Fu; Lu, Ting-Jang; Chang, Yu-Wei; Chen, Yung-Husan; Wang, Wei-Hsien; Wu, Yang-Chang; Sung, Ping-Jyun. 2013. "Cembrane Derivatives from the Soft Corals, Sinularia gaweli and Sinularia flexibilis." Mar. Drugs 11, no. 6: 2154-2167.