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Mar. Drugs 2013, 11(6), 2154-2167; doi:10.3390/md11062154
Article

Cembrane Derivatives from the Soft Corals, Sinularia gaweli and Sinularia flexibilis

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Received: 19 April 2013 / Revised: 20 May 2013 / Accepted: 5 June 2013 / Published: 17 June 2013
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Abstract

A new norcembranoidal diterpene, 1-epi-sinulanorcembranolide A (1), and a new cembranoidal diterpene, flexibilin D (2), were isolated from the soft corals, Sinularia gaweli and Sinularia flexibilis, respectively. The structures of new metabolites 1 and 2 were elucidated by spectroscopic methods, and compound 2 was found to significantly inhibit the accumulation of the pro-inflammatory iNOS and COX-2 proteins of the lipopolysaccharide (LPS)-stimulated RAW264.7 macrophage cells. In addition, S. flexibilis yielded a known cembrane, 5-dehydrosinulariolide (3); the structure, including its absolute stereochemistry, was further confirmed by single-crystal X-ray diffraction analysis.
Keywords: cembrane; norcembrane; Sinularia flexibilis; Sinularia gaweli; X-ray; anti-inflammatory activity cembrane; norcembrane; Sinularia flexibilis; Sinularia gaweli; X-ray; anti-inflammatory activity
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Hu, L.-C.; Yen, W.-H.; Su, J.-H.; Chiang, M.Y.-N.; Wen, Z.-H.; Chen, W.-F.; Lu, T.-J.; Chang, Y.-W.; Chen, Y.-H.; Wang, W.-H.; Wu, Y.-C.; Sung, P.-J. Cembrane Derivatives from the Soft Corals, Sinularia gaweli and Sinularia flexibilis. Mar. Drugs 2013, 11, 2154-2167.

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