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Mar. Drugs 2013, 11(6), 2042-2053; doi:10.3390/md11062042
Article

Four New Briarane Diterpenoids from Taiwanese Gorgonian Junceella fragilis

1,2
,
1,3
,
1
,
1
,
4
 and
1,*
1 School of Pharmacy, College of Medicine, National Taiwan University, Taipei 100, Taiwan 2 Department of Marine Biotechnology and Resources, National Sun Yat-Sen University, Kaohsiung 804, Taiwan 3 Department of Life Sciences, National Cheng Kung University, No. 1 University Road, Tainan 701, Taiwan 4 Graduate Institute of Natural Products, Chang Gung University, Taoyuan 333, Taiwan
* Author to whom correspondence should be addressed.
Received: 15 April 2013 / Revised: 22 May 2013 / Accepted: 27 May 2013 / Published: 10 June 2013
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Abstract

Four new 8-hydroxybriarane diterpenoids, frajunolides P–S (14), together with umbraculolide A, juncenolide C, junceellonoid A and juncin R, were isolated from the acetone extract of the gorgonian Junceella fragilis, collected from the southeast coast of Taiwan. Compound 1 contains an unusual pivaloyloxy group at C-2, while 3 is a rare compound having a chlorine atom on the olefinic carbon (C-6). The structures of the isolated compounds were established by extensive spectroscopic analysis, including 1D- and 2D-NMR, as well as HRMS data. Compound 1 was further confirmed by X-ray crystallographic analysis. In the anti-inflammatory test, compounds 1 and 2 exhibited moderate inhibition on superoxide anion generation and elastase release by human neutrophils in response to formylmethionylleucyl-phenylalanine/dihydrocytochalasin B (fMLP/CB).
Keywords: Junceella fragilis; briarane-type diterpenoids; frajunolides; anti-inflammatory Junceella fragilis; briarane-type diterpenoids; frajunolides; anti-inflammatory
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Liaw, C.-C.; Lin, Y.-C.; Lin, Y.-S.; Chen, C.-H.; Hwang, T.-L.; Shen, Y.-C. Four New Briarane Diterpenoids from Taiwanese Gorgonian Junceella fragilis. Mar. Drugs 2013, 11, 2042-2053.

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