Four New Briarane Diterpenoids from Taiwanese Gorgonian Junceella fragilis
AbstractFour new 8-hydroxybriarane diterpenoids, frajunolides P–S (1–4), together with umbraculolide A, juncenolide C, junceellonoid A and juncin R, were isolated from the acetone extract of the gorgonian Junceella fragilis, collected from the southeast coast of Taiwan. Compound 1 contains an unusual pivaloyloxy group at C-2, while 3 is a rare compound having a chlorine atom on the olefinic carbon (C-6). The structures of the isolated compounds were established by extensive spectroscopic analysis, including 1D- and 2D-NMR, as well as HRMS data. Compound 1 was further confirmed by X-ray crystallographic analysis. In the anti-inflammatory test, compounds 1 and 2 exhibited moderate inhibition on superoxide anion generation and elastase release by human neutrophils in response to formylmethionylleucyl-phenylalanine/dihydrocytochalasin B (fMLP/CB).
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Liaw, C.-C.; Lin, Y.-C.; Lin, Y.-S.; Chen, C.-H.; Hwang, T.-L.; Shen, Y.-C. Four New Briarane Diterpenoids from Taiwanese Gorgonian Junceella fragilis. Mar. Drugs 2013, 11, 2042-2053.
Liaw C-C, Lin Y-C, Lin Y-S, Chen C-H, Hwang T-L, Shen Y-C. Four New Briarane Diterpenoids from Taiwanese Gorgonian Junceella fragilis. Marine Drugs. 2013; 11(6):2042-2053.Chicago/Turabian Style
Liaw, Chia-Ching; Lin, Yu-Chi; Lin, Yun-Sheng; Chen, Chung-Hsiung; Hwang, Tsong-Long; Shen, Ya-Ching. 2013. "Four New Briarane Diterpenoids from Taiwanese Gorgonian Junceella fragilis." Mar. Drugs 11, no. 6: 2042-2053.