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Mar. Drugs 2013, 11(6), 2042-2053; doi:10.3390/md11062042

Four New Briarane Diterpenoids from Taiwanese Gorgonian Junceella fragilis

1 School of Pharmacy, College of Medicine, National Taiwan University, Taipei 100, Taiwan 2 Department of Marine Biotechnology and Resources, National Sun Yat-Sen University, Kaohsiung 804, Taiwan 3 Department of Life Sciences, National Cheng Kung University, No. 1 University Road, Tainan 701, Taiwan 4 Graduate Institute of Natural Products, Chang Gung University, Taoyuan 333, Taiwan
* Author to whom correspondence should be addressed.
Received: 15 April 2013 / Revised: 22 May 2013 / Accepted: 27 May 2013 / Published: 10 June 2013
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Four new 8-hydroxybriarane diterpenoids, frajunolides P–S (14), together with umbraculolide A, juncenolide C, junceellonoid A and juncin R, were isolated from the acetone extract of the gorgonian Junceella fragilis, collected from the southeast coast of Taiwan. Compound 1 contains an unusual pivaloyloxy group at C-2, while 3 is a rare compound having a chlorine atom on the olefinic carbon (C-6). The structures of the isolated compounds were established by extensive spectroscopic analysis, including 1D- and 2D-NMR, as well as HRMS data. Compound 1 was further confirmed by X-ray crystallographic analysis. In the anti-inflammatory test, compounds 1 and 2 exhibited moderate inhibition on superoxide anion generation and elastase release by human neutrophils in response to formylmethionylleucyl-phenylalanine/dihydrocytochalasin B (fMLP/CB).
Keywords: Junceella fragilis; briarane-type diterpenoids; frajunolides; anti-inflammatory Junceella fragilis; briarane-type diterpenoids; frajunolides; anti-inflammatory
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


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Liaw, C.-C.; Lin, Y.-C.; Lin, Y.-S.; Chen, C.-H.; Hwang, T.-L.; Shen, Y.-C. Four New Briarane Diterpenoids from Taiwanese Gorgonian Junceella fragilis. Mar. Drugs 2013, 11, 2042-2053.

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