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Mar. Drugs 2013, 11(6), 2042-2053; doi:10.3390/md11062042
Article

Four New Briarane Diterpenoids from Taiwanese Gorgonian Junceella fragilis

1,2
, 1,3
, 1
, 1
, 4
 and 1,*
Received: 15 April 2013; in revised form: 22 May 2013 / Accepted: 27 May 2013 / Published: 10 June 2013
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Abstract: Four new 8-hydroxybriarane diterpenoids, frajunolides P–S (14), together with umbraculolide A, juncenolide C, junceellonoid A and juncin R, were isolated from the acetone extract of the gorgonian Junceella fragilis, collected from the southeast coast of Taiwan. Compound 1 contains an unusual pivaloyloxy group at C-2, while 3 is a rare compound having a chlorine atom on the olefinic carbon (C-6). The structures of the isolated compounds were established by extensive spectroscopic analysis, including 1D- and 2D-NMR, as well as HRMS data. Compound 1 was further confirmed by X-ray crystallographic analysis. In the anti-inflammatory test, compounds 1 and 2 exhibited moderate inhibition on superoxide anion generation and elastase release by human neutrophils in response to formylmethionylleucyl-phenylalanine/dihydrocytochalasin B (fMLP/CB).
Keywords: Junceella fragilis; briarane-type diterpenoids; frajunolides; anti-inflammatory Junceella fragilis; briarane-type diterpenoids; frajunolides; anti-inflammatory
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Liaw, C.-C.; Lin, Y.-C.; Lin, Y.-S.; Chen, C.-H.; Hwang, T.-L.; Shen, Y.-C. Four New Briarane Diterpenoids from Taiwanese Gorgonian Junceella fragilis. Mar. Drugs 2013, 11, 2042-2053.

AMA Style

Liaw C-C, Lin Y-C, Lin Y-S, Chen C-H, Hwang T-L, Shen Y-C. Four New Briarane Diterpenoids from Taiwanese Gorgonian Junceella fragilis. Marine Drugs. 2013; 11(6):2042-2053.

Chicago/Turabian Style

Liaw, Chia-Ching; Lin, Yu-Chi; Lin, Yun-Sheng; Chen, Chung-Hsiung; Hwang, Tsong-Long; Shen, Ya-Ching. 2013. "Four New Briarane Diterpenoids from Taiwanese Gorgonian Junceella fragilis." Mar. Drugs 11, no. 6: 2042-2053.



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