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Mar. Drugs 2013, 11(6), 1783-1799; doi:10.3390/md11061783

The Promoting Effect of Ishige sinicola on Hair Growth

Received: 24 April 2013 / Revised: 8 May 2013 / Accepted: 9 May 2013 / Published: 24 May 2013
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This study was conducted to evaluate the promoting effect of Ishige sinicola, an alga native to Jeju Island, Korea, on hair growth. When vibrissa follicles were cultured in the presence of I. sinicola extract for 21 days, I. sinicola extract increased hair-fiber length. After topical application of I. sinicola extract onto the back of C57BL/6 mice, anagen progression of the hair shaft was induced. The I. sinicola extract significantly inhibited the activity of 5α-reductase. Treatment of immortalized vibrissa dermal papilla cells (DPCs) with I. sinicola extract resulted in increase of cell proliferation, which was accompanied by the increase of phospho-GSK3β level, β-catenin, Cyclin E and CDK2, whereas p27kip1 was down-regulated. In particular, octaphlorethol A, an isolated component from the I. sinicola extract, inhibited the activity of 5α-reductase and increased the proliferation of DPCs. These results suggest that I. sinicola extract and octaphlorethol A, a principal of I. sinicola, have the potential to treat alopecia via the proliferation of DPCs followed by the activation of β-catenin pathway, and the 5α-reductase inhibition.
Keywords: Ishige sinicola; hair growth; dermal papilla cells; β-catenin; 5α-reductase Ishige sinicola; hair growth; dermal papilla cells; β-catenin; 5α-reductase
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Kang, J.-I.; Kim, E.-J.; Kim, M.-K.; Jeon, Y.-J.; Kang, S.-M.; Koh, Y.-S.; Yoo, E.-S.; Kang, H.-K. The Promoting Effect of Ishige sinicola on Hair Growth. Mar. Drugs 2013, 11, 1783-1799.

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