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Mar. Drugs 2013, 11(3), 903-933; doi:10.3390/md11030903
Review

Marine-Derived Angiogenesis Inhibitors for Cancer Therapy

 and *
Received: 4 February 2013; in revised form: 25 February 2013 / Accepted: 1 March 2013 / Published: 15 March 2013
(This article belongs to the Special Issue Marine Compounds as Protein Kinase Inhibitors)
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Abstract: Angiogenesis inhibitors have been successfully used for cancer therapy in the clinic. Many marine-derived natural products and their analogues have been reported to show antiangiogenic activities. Compared with the drugs in the clinic, these agents display interesting characteristics, including diverse sources, unique chemical structures, special modes of action, and distinct activity and toxicity profiles. This review will first provide an overview of the current marine-derived angiogenesis inhibitors based on their primary targets and/or mechanisms of action. Then, the marine-derived antiangiogenic protein kinase inhibitors will be focused on. And finally, the clinical trials of the marine-derived antiangiogenic agents will be discussed, with special emphasis on their application potentials, problems and possible coping strategies in their future development as anticancer drugs.
Keywords: marine natural products; angiogenesis; protein kinase; cancer therapy marine natural products; angiogenesis; protein kinase; cancer therapy
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Wang, Y.-Q.; Miao, Z.-H. Marine-Derived Angiogenesis Inhibitors for Cancer Therapy. Mar. Drugs 2013, 11, 903-933.

AMA Style

Wang Y-Q, Miao Z-H. Marine-Derived Angiogenesis Inhibitors for Cancer Therapy. Marine Drugs. 2013; 11(3):903-933.

Chicago/Turabian Style

Wang, Ying-Qing; Miao, Ze-Hong. 2013. "Marine-Derived Angiogenesis Inhibitors for Cancer Therapy." Mar. Drugs 11, no. 3: 903-933.


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