Mar. Drugs 2013, 11(3), 870-880; doi:10.3390/md11030870
Article

The Protection of Polysaccharide from the Brown Seaweed Sargassum graminifolium against Ethylene Glycol-Induced Mitochondrial Damage

Received: 20 December 2012; in revised form: 1 February 2013 / Accepted: 6 February 2013 / Published: 13 March 2013
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: The aim of the present study is to evaluate the protective effect of polysaccharide from the Brown Seaweed Sargassum graminifolium (SGP) on ethylene glycol-induced kidney damage and the mechanism of SGP-mediated protection. Mitochondrial lipid peroxidation, mitochondrial swelling, the activity of succinate dehydrogenase (SDH), ATPases and mitochondrial antioxidant enzymes was observed in hyperoxaluric rats. Administration of SGP (25, 100 and 400 mg·kg−1, intragastrically) increased the activities of antioxidant enzymes, SDH and Na+/K+-ATPases, Ca2+-ATPases, Mg2+-ATPases, also decreased mitochondrial lipid peroxidation and mitochondrial swelling. SGP exhibited a protective effect by improving antioxidant enzymes and restoring mitochondrial dysfunction in the kidney of hyperoxaluric rats. It may be used as a promising therapeutic agent to provide superior renal protection.
Keywords: polysaccharide; mitochondrial damage; hyperoxaluric; urinary stones; reactive oxygen species (ROS)
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MDPI and ACS Style

Zhang, C.-Y.; Kong, T.; Wu, W.-H.; Lan, M.-B. The Protection of Polysaccharide from the Brown Seaweed Sargassum graminifolium against Ethylene Glycol-Induced Mitochondrial Damage. Mar. Drugs 2013, 11, 870-880.

AMA Style

Zhang C-Y, Kong T, Wu W-H, Lan M-B. The Protection of Polysaccharide from the Brown Seaweed Sargassum graminifolium against Ethylene Glycol-Induced Mitochondrial Damage. Marine Drugs. 2013; 11(3):870-880.

Chicago/Turabian Style

Zhang, Chao-Yan; Kong, Ting; Wu, Wen-Hui; Lan, Min-Bo. 2013. "The Protection of Polysaccharide from the Brown Seaweed Sargassum graminifolium against Ethylene Glycol-Induced Mitochondrial Damage." Mar. Drugs 11, no. 3: 870-880.

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