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The Protection of Polysaccharide from the Brown Seaweed Sargassum graminifolium against Ethylene Glycol-Induced Mitochondrial Damage
Shanghai Key Laboratory of Functional Materials Chemistry, Research Centre of Analysis and Test, East China University of Science and Technology, Shanghai 200237, China
College of Food Science and Technology, Institutes of Marine Sciences, Shanghai Ocean University, Shanghai 201306, China
* Author to whom correspondence should be addressed.
Received: 20 December 2012; in revised form: 1 February 2013 / Accepted: 6 February 2013 / Published: 13 March 2013
Abstract: The aim of the present study is to evaluate the protective effect of polysaccharide from the Brown Seaweed Sargassum graminifolium (SGP) on ethylene glycol-induced kidney damage and the mechanism of SGP-mediated protection. Mitochondrial lipid peroxidation, mitochondrial swelling, the activity of succinate dehydrogenase (SDH), ATPases and mitochondrial antioxidant enzymes was observed in hyperoxaluric rats. Administration of SGP (25, 100 and 400 mg·kg−1, intragastrically) increased the activities of antioxidant enzymes, SDH and Na+/K+-ATPases, Ca2+-ATPases, Mg2+-ATPases, also decreased mitochondrial lipid peroxidation and mitochondrial swelling. SGP exhibited a protective effect by improving antioxidant enzymes and restoring mitochondrial dysfunction in the kidney of hyperoxaluric rats. It may be used as a promising therapeutic agent to provide superior renal protection.
Keywords: polysaccharide; mitochondrial damage; hyperoxaluric; urinary stones; reactive oxygen species (ROS)
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MDPI and ACS Style
Zhang, C.-Y.; Kong, T.; Wu, W.-H.; Lan, M.-B. The Protection of Polysaccharide from the Brown Seaweed Sargassum graminifolium against Ethylene Glycol-Induced Mitochondrial Damage. Mar. Drugs 2013, 11, 870-880.
Zhang C-Y, Kong T, Wu W-H, Lan M-B. The Protection of Polysaccharide from the Brown Seaweed Sargassum graminifolium against Ethylene Glycol-Induced Mitochondrial Damage. Marine Drugs. 2013; 11(3):870-880.
Zhang, Chao-Yan; Kong, Ting; Wu, Wen-Hui; Lan, Min-Bo. 2013. "The Protection of Polysaccharide from the Brown Seaweed Sargassum graminifolium against Ethylene Glycol-Induced Mitochondrial Damage." Mar. Drugs 11, no. 3: 870-880.