Mar. Drugs 2013, 11(2), 455-465; doi:10.3390/md11020455
Article

New Casbane Diterpenoids from a South China Sea Soft Coral, Sinularia sp.

Jian Yin 1,† email, Min Zhao 1,† email, Minshan Ma 2 email, Yuping Xu 1 email, Zheng Xiang 1 email, Yuepiao Cai 1 email, Jianyong Dong 1 email, Xinxiang Lei 2 email, Kexin Huang 1,* email and Pengcheng Yan 1,* email
1 School of Pharmacy, Wenzhou Medical College, Wenzhou 325035, China 2 Analytical and Testing Center, Wenzhou University, Wenzhou 325035, China † These authors contributed equally to this work.
* Authors to whom correspondence should be addressed.
Received: 6 November 2012; in revised form: 15 January 2013 / Accepted: 29 January 2013 / Published: 6 February 2013
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Abstract: Six new casbane diterpenoids, named as sinularcasbanes A–F (1–6), along with six known analogues 7–12, were isolated from a South China Sea soft coral, Sinularia sp. The structures of the new compounds were elucidated by extensive spectroscopic analysis and by comparison with data reported in the literature. All compounds were evaluated for their cytotoxicity against selected cancer cell lines and the inhibition of lipopolysaccharide (LPS)-induced nitric oxide (NO) production in mouse peritoneal macrophages.
Keywords: soft coral; Sinularia; casbane diterpenoids; cytotoxicity; NO inhibition

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Cite This Article

MDPI and ACS Style

Yin, J.; Zhao, M.; Ma, M.; Xu, Y.; Xiang, Z.; Cai, Y.; Dong, J.; Lei, X.; Huang, K.; Yan, P. New Casbane Diterpenoids from a South China Sea Soft Coral, Sinularia sp.. Mar. Drugs 2013, 11, 455-465.

AMA Style

Yin J, Zhao M, Ma M, Xu Y, Xiang Z, Cai Y, Dong J, Lei X, Huang K, Yan P. New Casbane Diterpenoids from a South China Sea Soft Coral, Sinularia sp.. Marine Drugs. 2013; 11(2):455-465.

Chicago/Turabian Style

Yin, Jian; Zhao, Min; Ma, Minshan; Xu, Yuping; Xiang, Zheng; Cai, Yuepiao; Dong, Jianyong; Lei, Xinxiang; Huang, Kexin; Yan, Pengcheng. 2013. "New Casbane Diterpenoids from a South China Sea Soft Coral, Sinularia sp.." Mar. Drugs 11, no. 2: 455-465.

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