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Novel One-Pot Green Synthesis of Indolizines Biocatalysed by Candida antarctica Lipases
Department of Chemistry, Physics and Environment, Faculty of Science and Environment, "Dunarea de Jos" University of Galati, 111 Domneasca Street, Galati 800201, Romania
Department of Food Science, Food Engineering and Applied Biotechnology, Faculty of Food Science and Engineering, "Dunarea de Jos" University of Galati, 111 Domneasca Street, Galati 800201, Romania
Pharmacochimie Moléculaire, UMR 5063 & FR 2607, CNRS/Université de Grenoble, 38041 Grenoble cedex 9, France
* Authors to whom correspondence should be addressed.
Received: 29 December 2012; in revised form: 29 January 2013 / Accepted: 29 January 2013 / Published: 6 February 2013
Abstract: Marine microorganisms are of considerable interest as a promising source of enzymes with unsuspected potentials as catalysts for chemical synthesis. We describe here an efficient method for one-pot indolizine synthesis that has been developed using lipase A and lipase B from Candida antarctica as biocatalysts. As showed by HPLC/MS analysis, the yield in indolizines was higher in the presence of the biocatalyst than in absence of enzyme. Lipase A, from Candida antarctica, showed high catalytic activity and selectivity for the cycloaddition reactions. When the reactions were performed under ultrasound irradiation, the Candida antarctica lipase catalyzed reactions yielded pure indolozines, in good yields and in very short time.
Keywords: indolizine; Candida antarctica lipase; one-pot reaction; cycloaddition; ylide
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Dinica, R.M.; Furdui, B.; Ghinea, I.O.; Bahrim, G.; Bonte, S.; Demeunynck, M. Novel One-Pot Green Synthesis of Indolizines Biocatalysed by Candida antarctica Lipases. Mar. Drugs 2013, 11, 431-439.
Dinica RM, Furdui B, Ghinea IO, Bahrim G, Bonte S, Demeunynck M. Novel One-Pot Green Synthesis of Indolizines Biocatalysed by Candida antarctica Lipases. Marine Drugs. 2013; 11(2):431-439.
Dinica, Rodica M.; Furdui, Bianca; Ghinea, Ioana O.; Bahrim, Gabriela; Bonte, Simon; Demeunynck, Martine. 2013. "Novel One-Pot Green Synthesis of Indolizines Biocatalysed by Candida antarctica Lipases." Mar. Drugs 11, no. 2: 431-439.