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Cytotoxic Effects of Fucoidan Nanoparticles against Osteosarcoma
Department of Microbiology and Oncology, Graduate School of Medicine, University of the Ryukyus, 207 Uehara, Nishihara, Okinawa 903-0215, Japan
Transdisciplinary Research Organization for Subtropics and Island Studies, University of the Ryukyus, 1 Senbaru, Nishihara, Okinawa 903-0213, Japan
Department of Orthopedic Surgery, Graduate School of Medicine, University of the Ryukyus, 207 Uehara, Nishihara, Okinawa 903-0215, Japan
Kanehide Bio Co., Ltd., 5-2-2 Nishizaki-cho, Itoman, Okinawa 901-0305, Japan
Department of Pathology, Institute of Tropical Medicine, Nagasaki University, 1-12-4 Sakamoto, Nagasaki 852-8523, Japan
* Author to whom correspondence should be addressed.
Received: 6 September 2013; in revised form: 18 October 2013 / Accepted: 18 October 2013 / Published: 30 October 2013
Abstract: In this study, we analyzed the size-dependent bioactivities of fucoidan by comparing the cytotoxic effects of native fucoidan and fucoidan lipid nanoparticles on osteosarcoma in vitro and in vivo. In vitro experiments indicated that nanoparticle fucoidan induced apoptosis of an osteosarcoma cell line more efficiently than native fucoidan. The more potent effects of nanoparticle fucoidan, relative to native fucoidan, were confirmed in vivo using a xenograft osteosarcoma model. Caco-2 cell transport studies showed that permeation of nanoparticle fucoidan was higher than native fucoidan. The higher bioactivity and superior bioavailability of nanoparticle fucoidan could potentially be utilized to develop novel therapies for osteosarcoma.
Keywords: fucoidan; nanoparticle; osteosarcoma; apoptosis; lung metastasis
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Kimura, R.; Rokkaku, T.; Takeda, S.; Senba, M.; Mori, N. Cytotoxic Effects of Fucoidan Nanoparticles against Osteosarcoma. Mar. Drugs 2013, 11, 4267-4278.
Kimura R, Rokkaku T, Takeda S, Senba M, Mori N. Cytotoxic Effects of Fucoidan Nanoparticles against Osteosarcoma. Marine Drugs. 2013; 11(11):4267-4278.
Kimura, Ryuichiro; Rokkaku, Takayoshi; Takeda, Shinji; Senba, Masachika; Mori, Naoki. 2013. "Cytotoxic Effects of Fucoidan Nanoparticles against Osteosarcoma." Mar. Drugs 11, no. 11: 4267-4278.