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Mar. Drugs 2013, 11(11), 4267-4278; doi:10.3390/md11114267
Article

Cytotoxic Effects of Fucoidan Nanoparticles against Osteosarcoma

1,2
, 1,3
, 4
, 5
 and 1,*
Received: 6 September 2013; in revised form: 18 October 2013 / Accepted: 18 October 2013 / Published: 30 October 2013
(This article belongs to the Special Issue Marine Compounds and Cancer)
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Abstract: In this study, we analyzed the size-dependent bioactivities of fucoidan by comparing the cytotoxic effects of native fucoidan and fucoidan lipid nanoparticles on osteosarcoma in vitro and in vivo. In vitro experiments indicated that nanoparticle fucoidan induced apoptosis of an osteosarcoma cell line more efficiently than native fucoidan. The more potent effects of nanoparticle fucoidan, relative to native fucoidan, were confirmed in vivo using a xenograft osteosarcoma model. Caco-2 cell transport studies showed that permeation of nanoparticle fucoidan was higher than native fucoidan. The higher bioactivity and superior bioavailability of nanoparticle fucoidan could potentially be utilized to develop novel therapies for osteosarcoma.
Keywords: fucoidan; nanoparticle; osteosarcoma; apoptosis; lung metastasis fucoidan; nanoparticle; osteosarcoma; apoptosis; lung metastasis
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Kimura, R.; Rokkaku, T.; Takeda, S.; Senba, M.; Mori, N. Cytotoxic Effects of Fucoidan Nanoparticles against Osteosarcoma. Mar. Drugs 2013, 11, 4267-4278.

AMA Style

Kimura R, Rokkaku T, Takeda S, Senba M, Mori N. Cytotoxic Effects of Fucoidan Nanoparticles against Osteosarcoma. Marine Drugs. 2013; 11(11):4267-4278.

Chicago/Turabian Style

Kimura, Ryuichiro; Rokkaku, Takayoshi; Takeda, Shinji; Senba, Masachika; Mori, Naoki. 2013. "Cytotoxic Effects of Fucoidan Nanoparticles against Osteosarcoma." Mar. Drugs 11, no. 11: 4267-4278.


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