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Mar. Drugs 2013, 11(10), 4058-4082; doi:10.3390/md11104058

Trypanocidal Activity of Marine Natural Products

 and *
Received: 16 August 2013 / Revised: 9 October 2013 / Accepted: 10 October 2013 / Published: 22 October 2013
(This article belongs to the Special Issue Antiprotozoal Marine Natural Products)
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Abstract: Marine natural products are a diverse, unique collection of compounds with immense therapeutic potential. This has resulted in these molecules being evaluated for a number of different disease indications including the neglected protozoan diseases, human African trypanosomiasis and Chagas disease, for which very few drugs are currently available. This article will review the marine natural products for which activity against the kinetoplastid parasites; Trypanosoma brucei brucei, T.b. rhodesiense and T. cruzi has been reported. As it is important to know the selectivity of a compound when evaluating its trypanocidal activity, this article will only cover molecules which have simultaneously been tested for cytotoxicity against a mammalian cell line. Compounds have been grouped according to their chemical structure and representative examples from each class were selected for detailed discussion.
Keywords: human African trypanosomiasis; sleeping sickness; chagas disease; marine natural products; drug discovery human African trypanosomiasis; sleeping sickness; chagas disease; marine natural products; drug discovery
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Jones, A.J.; Grkovic, T.; Sykes, M.L.; Avery, V.M. Trypanocidal Activity of Marine Natural Products. Mar. Drugs 2013, 11, 4058-4082.

AMA Style

Jones AJ, Grkovic T, Sykes ML, Avery VM. Trypanocidal Activity of Marine Natural Products. Marine Drugs. 2013; 11(10):4058-4082.

Chicago/Turabian Style

Jones, Amy J.; Grkovic, Tanja; Sykes, Melissa L.; Avery, Vicky M. 2013. "Trypanocidal Activity of Marine Natural Products." Mar. Drugs 11, no. 10: 4058-4082.

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