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Mar. Drugs 2013, 11(10), 4050-4057; doi:10.3390/md11104050
Communication

Red Algal Bromophenols as Glucose 6-Phosphate Dehydrogenase Inhibitors

1
,
1,* , 2
 and
1
1 Faculty and Graduate School of Fisheries Sciences, Hokkaido University, Minato, Hakodate, Hokkaido 041-8611, Japan 2 Department of Marine Food Science and Technology, Gangneung-Wonju National University, Gangneung, Gangwon-do 210-702, Korea
* Author to whom correspondence should be addressed.
Received: 8 August 2013 / Revised: 31 August 2013 / Accepted: 2 September 2013 / Published: 22 October 2013
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Abstract

Five bromophenols isolated from three Rhodomelaceae algae (Laurencia nipponica, Polysiphonia morrowii, Odonthalia corymbifera) showed inhibitory effects against glucose 6-phosphate dehydrogenase (G6PD). Among them, the symmetric bromophenol dimer (5) showed the highest inhibitory activity against G6PD.
Keywords: bromophenol; Rhodomelaceae; pentose phosphate pathway (PPP); glucose 6-phosphate dehydrogenase; inhibition bromophenol; Rhodomelaceae; pentose phosphate pathway (PPP); glucose 6-phosphate dehydrogenase; inhibition
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Mikami, D.; Kurihara, H.; Kim, S.M.; Takahashi, K. Red Algal Bromophenols as Glucose 6-Phosphate Dehydrogenase Inhibitors. Mar. Drugs 2013, 11, 4050-4057.

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