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Mar. Drugs 2012, 10(9), 2126-2137; doi:10.3390/md10092126
Article

Cyclic Bis-1,3-dialkylpyridiniums from the Sponge Haliclona sp.

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Received: 12 July 2012; in revised form: 9 August 2012 / Accepted: 14 September 2012 / Published: 24 September 2012
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Abstract: Eight novel cyclic bis-1,3-dialkylpyridiniums, as well as two known compounds from the cyclostellettamine class, were isolated from the sponge Haliclona sp. from Korea. Structures of these novel compounds were determined using combined NMR and FAB-MS/MS analyses. Several of these compounds exhibited moderate cytotoxic and antibacterial activities against A549 cell-line and Gram-positive strains, respectively. The structure-activity relationships of cyclostellettamines are discussed based on their bioactivities.
Keywords: Haliclona sp.; bis-1,3-dialkylpyridiniums; cyclostellettamines; cytotoxicity; antimicrobial activity Haliclona sp.; bis-1,3-dialkylpyridiniums; cyclostellettamines; cytotoxicity; antimicrobial activity
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Lee, Y.; Jang, K.H.; Jeon, J.-E.; Yang, W.-Y.; Sim, C.J.; Oh, K.-B.; Shin, J. Cyclic Bis-1,3-dialkylpyridiniums from the Sponge Haliclona sp.. Mar. Drugs 2012, 10, 2126-2137.

AMA Style

Lee Y, Jang KH, Jeon J-E, Yang W-Y, Sim CJ, Oh K-B, Shin J. Cyclic Bis-1,3-dialkylpyridiniums from the Sponge Haliclona sp.. Marine Drugs. 2012; 10(9):2126-2137.

Chicago/Turabian Style

Lee, Yoonyeong; Jang, Kyoung Hwa; Jeon, Ju-eun; Yang, Woo-Young; Sim, Chung J.; Oh, Ki-Bong; Shin, Jongheon. 2012. "Cyclic Bis-1,3-dialkylpyridiniums from the Sponge Haliclona sp.." Mar. Drugs 10, no. 9: 2126-2137.



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