Next Article in Journal
Structural Analysis of a Heteropolysaccharide from Saccharina japonica by Electrospray Mass Spectrometry in Tandem with Collision-Induced Dissociation Tandem Mass Spectrometry (ESI-CID-MS/MS)
Previous Article in Journal
Dose-Response on the Chemopreventive Effects of Sarcophine-Diol on UVB-Induced Skin Tumor Development in SKH-1 Hairless Mice
Article Menu

Export Article

Open AccessArticle
Mar. Drugs 2012, 10(9), 2126-2137; doi:10.3390/md10092126

Cyclic Bis-1,3-dialkylpyridiniums from the Sponge Haliclona sp.

1
Natural Products Research Institute, College of Pharmacy, Seoul National University, San 56-1, Sillim, Gwanak, Seoul 151-742, Korea
2
Department of Agricultural Biotechnology, College of Agriculture & Life Science, Seoul National University, San 56-1, Sillim, Gwanak, Seoul 151-921, Korea
3
Department of Biological Science, College of Life Science and Nano Technology, Hannam University, 461-6 Jeonmin, Yuseong, Daejeon 305-811, Korea
*
Authors to whom correspondence should be addressed.
Received: 12 July 2012 / Revised: 9 August 2012 / Accepted: 14 September 2012 / Published: 24 September 2012
View Full-Text   |   Download PDF [678 KB, 24 February 2015; original version 24 February 2015]   |  

Abstract

Eight novel cyclic bis-1,3-dialkylpyridiniums, as well as two known compounds from the cyclostellettamine class, were isolated from the sponge Haliclona sp. from Korea. Structures of these novel compounds were determined using combined NMR and FAB-MS/MS analyses. Several of these compounds exhibited moderate cytotoxic and antibacterial activities against A549 cell-line and Gram-positive strains, respectively. The structure-activity relationships of cyclostellettamines are discussed based on their bioactivities. View Full-Text
Keywords: Haliclona sp.; bis-1,3-dialkylpyridiniums; cyclostellettamines; cytotoxicity; antimicrobial activity Haliclona sp.; bis-1,3-dialkylpyridiniums; cyclostellettamines; cytotoxicity; antimicrobial activity
Figures

This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

Supplementary material

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Lee, Y.; Jang, K.H.; Jeon, J.-E.; Yang, W.-Y.; Sim, C.J.; Oh, K.-B.; Shin, J. Cyclic Bis-1,3-dialkylpyridiniums from the Sponge Haliclona sp.. Mar. Drugs 2012, 10, 2126-2137.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Mar. Drugs EISSN 1660-3397 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top