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Mar. Drugs 2012, 10(9), 2126-2137; doi:10.3390/md10092126
Article

Cyclic Bis-1,3-dialkylpyridiniums from the Sponge Haliclona sp.

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1 Natural Products Research Institute, College of Pharmacy, Seoul National University, San 56-1, Sillim, Gwanak, Seoul 151-742, Korea 2 Department of Agricultural Biotechnology, College of Agriculture & Life Science, Seoul National University, San 56-1, Sillim, Gwanak, Seoul 151-921, Korea 3 Department of Biological Science, College of Life Science and Nano Technology, Hannam University, 461-6 Jeonmin, Yuseong, Daejeon 305-811, Korea
* Authors to whom correspondence should be addressed.
Received: 12 July 2012 / Revised: 9 August 2012 / Accepted: 14 September 2012 / Published: 24 September 2012
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Abstract

Eight novel cyclic bis-1,3-dialkylpyridiniums, as well as two known compounds from the cyclostellettamine class, were isolated from the sponge Haliclona sp. from Korea. Structures of these novel compounds were determined using combined NMR and FAB-MS/MS analyses. Several of these compounds exhibited moderate cytotoxic and antibacterial activities against A549 cell-line and Gram-positive strains, respectively. The structure-activity relationships of cyclostellettamines are discussed based on their bioactivities.
Keywords: Haliclona sp.; bis-1,3-dialkylpyridiniums; cyclostellettamines; cytotoxicity; antimicrobial activity Haliclona sp.; bis-1,3-dialkylpyridiniums; cyclostellettamines; cytotoxicity; antimicrobial activity
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Lee, Y.; Jang, K.H.; Jeon, J.-E.; Yang, W.-Y.; Sim, C.J.; Oh, K.-B.; Shin, J. Cyclic Bis-1,3-dialkylpyridiniums from the Sponge Haliclona sp.. Mar. Drugs 2012, 10, 2126-2137.

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