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Mar. Drugs 2012, 10(9), 2103-2110; doi:10.3390/md10092103
Article

Briacavatolides D–F, New Briaranes from the Taiwanese Octocoral Briareum excavatum

1,2
, 3
 and 1,3,*
1 Asia-Pacific Ocean Research Center, National Sun Yat-Sen University, Kaohsiung 804, Taiwan 2 Department of Microbiology, Kaohsiung Medical University, Kaohsiung 807, Taiwan 3 Department of Marine Biotechnology and Resources, National Sun Yat-Sen University, Kaohsiung 804, Taiwan
* Author to whom correspondence should be addressed.
Received: 17 August 2012 / Revised: 18 September 2012 / Accepted: 18 September 2012 / Published: 24 September 2012
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Abstract

In the continued search for novel bioactive substances from the Taiwanese octocoral Briareum excavatum collected at Orchid Island, three new briarane-type diterpenoids, briacavatolides D–F (13) were isolated from the acetone extract. The structures of these compounds were elucidated by extensive NMR spectroscopic analysis and physical data. The anti-HCMV (human cytomegalovirus) activity of 13 and their cytotoxicity against selected cancer cell lines were evaluated.
Keywords: Briareum excavatum; briarane-type diterpenoid; cytotoxicity; anti-HCMV Briareum excavatum; briarane-type diterpenoid; cytotoxicity; anti-HCMV
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Wang, S.-K.; Yeh, T.-T.; Duh, C.-Y. Briacavatolides D–F, New Briaranes from the Taiwanese Octocoral Briareum excavatum. Mar. Drugs 2012, 10, 2103-2110.

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