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Mar. Drugs 2012, 10(9), 2103-2110; doi:10.3390/md10092103

Article

Briacavatolides D–F, New Briaranes from the Taiwanese Octocoral Briareum excavatum

Shang-Kwei Wang ^1,2 , Tsun-Tai Yeh ³  and Chang-Yih Duh ^1,3,*

¹ Asia-Pacific Ocean Research Center, National Sun Yat-Sen University, Kaohsiung 804, Taiwan ² Department of Microbiology, Kaohsiung Medical University, Kaohsiung 807, Taiwan ³ Department of Marine Biotechnology and Resources, National Sun Yat-Sen University, Kaohsiung 804, Taiwan

* Author to whom correspondence should be addressed.

Received: 17 August 2012; in revised form: 18 September 2012 / Accepted: 18 September 2012 / Published: 24 September 2012

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Abstract: In the continued search for novel bioactive substances from the Taiwanese octocoral Briareum excavatum collected at Orchid Island, three new briarane-type diterpenoids, briacavatolides D–F (1–3) were isolated from the acetone extract. The structures of these compounds were elucidated by extensive NMR spectroscopic analysis and physical data. The anti-HCMV (human cytomegalovirus) activity of 1–3 and their cytotoxicity against selected cancer cell lines were evaluated.

Keywords: Briareum excavatum; briarane-type diterpenoid; cytotoxicity; anti-HCMV

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