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Mar. Drugs 2012, 10(9), 2103-2110; doi:10.3390/md10092103
Article

Briacavatolides D–F, New Briaranes from the Taiwanese Octocoral Briareum excavatum

1,2
,
3
 and
1,3,*
1 Asia-Pacific Ocean Research Center, National Sun Yat-Sen University, Kaohsiung 804, Taiwan 2 Department of Microbiology, Kaohsiung Medical University, Kaohsiung 807, Taiwan 3 Department of Marine Biotechnology and Resources, National Sun Yat-Sen University, Kaohsiung 804, Taiwan
* Author to whom correspondence should be addressed.
Received: 17 August 2012 / Revised: 18 September 2012 / Accepted: 18 September 2012 / Published: 24 September 2012
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Abstract

In the continued search for novel bioactive substances from the Taiwanese octocoral Briareum excavatum collected at Orchid Island, three new briarane-type diterpenoids, briacavatolides D–F (13) were isolated from the acetone extract. The structures of these compounds were elucidated by extensive NMR spectroscopic analysis and physical data. The anti-HCMV (human cytomegalovirus) activity of 13 and their cytotoxicity against selected cancer cell lines were evaluated.
Keywords: Briareum excavatum; briarane-type diterpenoid; cytotoxicity; anti-HCMV Briareum excavatum; briarane-type diterpenoid; cytotoxicity; anti-HCMV
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Wang, S.-K.; Yeh, T.-T.; Duh, C.-Y. Briacavatolides D–F, New Briaranes from the Taiwanese Octocoral Briareum excavatum. Mar. Drugs 2012, 10, 2103-2110.

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