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Mar. Drugs 2012, 10(8), 1799-1811; doi:10.3390/md10081799
Article

Chemistry of the Nudibranch Aldisa andersoni: Structure and Biological Activity of Phorbazole Metabolites

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1 CNR, Instituto di Chimica Biomolecolare, Via Campi Flegrei 34, I-80078 Pozzuoli, Naples, Italy 2 Laboratoire de Toxicologie, Faculté de Pharmacie, Université Libre de Bruxelles (ULB), Campus de la Plaine, Boulevard du Triomphe, 1050, Brussels, Belgium 3 Service de Neurochirurgie, Hôpital Erasme, ULB, Route de Lennik, 1070 Brussels, Belgium 4 CSIR—National Institute of Oceanography, 403 004 Dona Paula, Goa, India
* Author to whom correspondence should be addressed.
Received: 25 June 2012 / Revised: 18 July 2012 / Accepted: 8 August 2012 / Published: 20 August 2012
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Abstract

The first chemical study of the Indo-Pacific dorid nudibranch Aldisa andersoni resulted in the isolation of five chlorinated phenyl-pyrrolyloxazoles belonging to the phorbazole series. Two new molecules, 9-chloro-phorbazole D and N1-methyl-phorbazole A, co-occurring with known phorbazoles A, B and D, have been characterized. Phorbazoles were found to be present mainly in the external part of the mollusc. The structures of the new compounds were determined by interpretation of spectroscopic data, mainly NMR and mass spectrometry and by comparison with the literature data. Evaluation of feeding-deterrence activity as well as in vitro growth inhibitory properties in human cancer cells was also carried out.
Keywords: Aldisa andersoni; nudibranch mollusc; structural elucidation; feeding-deterrence; growth inhibitory assays Aldisa andersoni; nudibranch mollusc; structural elucidation; feeding-deterrence; growth inhibitory assays
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Nuzzo, G.; Ciavatta, M.L.; Kiss, R.; Mathieu, V.; Leclercqz, H.; Manzo, E.; Villani, G.; Mollo, E.; Lefranc, F.; D’Souza, L.; Gavagnin, M.; Cimino, G. Chemistry of the Nudibranch Aldisa andersoni: Structure and Biological Activity of Phorbazole Metabolites. Mar. Drugs 2012, 10, 1799-1811.

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