4-Methylenesterols from a Sponge Theonella swinhoei

doi:10.3390/md10071536

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Mar. Drugs 2012, 10(7), 1536-1544; doi:10.3390/md10071536

Article

4-Methylenesterols from a Sponge Theonella swinhoei

Jheng-Kun Guo^1,2, Ching-Ying Chiang³, Mei-Chin Lu^1,4, Wen-Been Chang^1,2,* and Jui-Hsin Su^1,4,5,*

¹ National Museum of Marine Biology & Aquarium, Pingtung 944, Taiwan ² Graduate Institute of Marine Biodiversity and Evolutionary Biology, National Dong Hwa University, Pingtung 944, Taiwan ³ Center of General Studies, National Kaohsiung Marine University, Kaohsiung 811, Taiwan ⁴ Graduate Institute of Marine Biotechnology, National Dong Hwa University, Pingtung 944, Taiwan ⁵ Asia-Pacific Ocean Research Center, National Sun Yat-sen University, Kaohsiung 804, Taiwan

* Authors to whom correspondence should be addressed.

Received: 11 June 2012; in revised form: 28 June 2012 / Accepted: 11 July 2012 / Published: 19 July 2012

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Abstract: Three new 4-methylenesterols, theonellasterol K (1), acetyltheonellasterol (2) and acetyldehydroconicasterol (3), along with two known sterols, theonellasterol (4) and theonellasterone (5), were isolated from the sponge Theonella swinhoei. The structures of these compounds were elucidated on the basis of their spectroscopic data and comparison of the NMR data with those of known analogues. Compound 1 exhibited significant cytotoxic activity against HCT-116, K562 and Molt 4 cancer cell lines.

Keywords: 4-methylenesterols; sponge; Theonella

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Cite This Article

MDPI and ACS Style

Guo, J.-K.; Chiang, C.-Y.; Lu, M.-C.; Chang, W.-B.; Su, J.-H. 4-Methylenesterols from a Sponge Theonella swinhoei. Mar. Drugs 2012, 10, 1536-1544.

AMA Style

Guo J-K, Chiang C-Y, Lu M-C, Chang W-B, Su J-H. 4-Methylenesterols from a Sponge Theonella swinhoei. Marine Drugs. 2012; 10(7):1536-1544.

Chicago/Turabian Style

Guo, Jheng-Kun; Chiang, Ching-Ying; Lu, Mei-Chin; Chang, Wen-Been; Su, Jui-Hsin. 2012. "4-Methylenesterols from a Sponge Theonella swinhoei." Mar. Drugs 10, no. 7: 1536-1544.

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