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Mar. Drugs 2012, 10(7), 1536-1544; doi:10.3390/md10071536

4-Methylenesterols from a Sponge Theonella swinhoei

1,2,*  and 1,4,5,*
1 National Museum of Marine Biology & Aquarium, Pingtung 944, Taiwan 2 Graduate Institute of Marine Biodiversity and Evolutionary Biology, National Dong Hwa University, Pingtung 944, Taiwan 3 Center of General Studies, National Kaohsiung Marine University, Kaohsiung 811, Taiwan 4 Graduate Institute of Marine Biotechnology, National Dong Hwa University, Pingtung 944, Taiwan 5 Asia-Pacific Ocean Research Center, National Sun Yat-sen University, Kaohsiung 804, Taiwan
* Authors to whom correspondence should be addressed.
Received: 11 June 2012 / Revised: 28 June 2012 / Accepted: 11 July 2012 / Published: 19 July 2012
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Three new 4-methylenesterols, theonellasterol K (1), acetyltheonellasterol (2) and acetyldehydroconicasterol (3), along with two known sterols, theonellasterol (4) and theonellasterone (5), were isolated from the sponge Theonella swinhoei. The structures of these compounds were elucidated on the basis of their spectroscopic data and comparison of the NMR data with those of known analogues. Compound 1 exhibited significant cytotoxic activity against HCT-116, K562 and Molt 4 cancer cell lines.
Keywords: 4-methylenesterols; sponge; Theonella 4-methylenesterols; sponge; Theonella
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Guo, J.-K.; Chiang, C.-Y.; Lu, M.-C.; Chang, W.-B.; Su, J.-H. 4-Methylenesterols from a Sponge Theonella swinhoei. Mar. Drugs 2012, 10, 1536-1544.

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