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Mar. Drugs 2012, 10(7), 1536-1544; doi:10.3390/md10071536
Article

4-Methylenesterols from a Sponge Theonella swinhoei

1,2
, 3
, 1,4
, 1,2,*  and 1,4,5,*
Received: 11 June 2012; in revised form: 28 June 2012 / Accepted: 11 July 2012 / Published: 19 July 2012
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Abstract: Three new 4-methylenesterols, theonellasterol K (1), acetyltheonellasterol (2) and acetyldehydroconicasterol (3), along with two known sterols, theonellasterol (4) and theonellasterone (5), were isolated from the sponge Theonella swinhoei. The structures of these compounds were elucidated on the basis of their spectroscopic data and comparison of the NMR data with those of known analogues. Compound 1 exhibited significant cytotoxic activity against HCT-116, K562 and Molt 4 cancer cell lines.
Keywords: 4-methylenesterols; sponge; Theonella 4-methylenesterols; sponge; Theonella
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Guo, J.-K.; Chiang, C.-Y.; Lu, M.-C.; Chang, W.-B.; Su, J.-H. 4-Methylenesterols from a Sponge Theonella swinhoei. Mar. Drugs 2012, 10, 1536-1544.

AMA Style

Guo J-K, Chiang C-Y, Lu M-C, Chang W-B, Su J-H. 4-Methylenesterols from a Sponge Theonella swinhoei. Marine Drugs. 2012; 10(7):1536-1544.

Chicago/Turabian Style

Guo, Jheng-Kun; Chiang, Ching-Ying; Lu, Mei-Chin; Chang, Wen-Been; Su, Jui-Hsin. 2012. "4-Methylenesterols from a Sponge Theonella swinhoei." Mar. Drugs 10, no. 7: 1536-1544.



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