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Mar. Drugs 2012, 10(6), 1307-1320; doi:10.3390/md10061307
Article

Marine Cyclotripeptide X-13 Promotes Angiogenesis in Zebrafish and Human Endothelial Cells via PI3K/Akt/eNOS Signaling Pathways

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Received: 4 March 2012; in revised form: 8 May 2012 / Accepted: 29 May 2012 / Published: 7 June 2012
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Abstract: Cyclotripeptide X-13 is a core of novel marine compound xyloallenoide A isolated from mangrove fungus Xylaria sp. (no. 2508). We found that X-13 dose-dependently induced angiogenesis in zebrafish embryos and in human endothelial cells, which was accompanied by increased phosphorylation of eNOS and Akt and NO release. Inhibition of PI3K/Akt/eNOS by LY294002 or l-NAME suppressed X-13-induced angiogenesis. The present work demonstrates that X-13 promotes angiogenesis via PI3K/Akt/eNOS pathways.
Keywords: angiogenesis; marine cyclotripeptide; zebrafish; endothelial nitric oxide synthase; xyloallenoide A angiogenesis; marine cyclotripeptide; zebrafish; endothelial nitric oxide synthase; xyloallenoide A
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Lu, X.-L.; Xu, Z.-L.; Yao, X.-L.; Su, F.-J.; Ye, C.-H.; Li, J.; Lin, Y.-C.; Wang, G.-L.; Zeng, J.-S.; Huang, R.-X.; Ou, J.-S.; Sun, H.-S.; Wang, L.-P.; Pang, J.-Y.; Pei, Z. Marine Cyclotripeptide X-13 Promotes Angiogenesis in Zebrafish and Human Endothelial Cells via PI3K/Akt/eNOS Signaling Pathways. Mar. Drugs 2012, 10, 1307-1320.

AMA Style

Lu X-L, Xu Z-L, Yao X-L, Su F-J, Ye C-H, Li J, Lin Y-C, Wang G-L, Zeng J-S, Huang R-X, Ou J-S, Sun H-S, Wang L-P, Pang J-Y, Pei Z. Marine Cyclotripeptide X-13 Promotes Angiogenesis in Zebrafish and Human Endothelial Cells via PI3K/Akt/eNOS Signaling Pathways. Marine Drugs. 2012; 10(6):1307-1320.

Chicago/Turabian Style

Lu, Xi-Lin; Xu, Zhong-Liang; Yao, Xiao-Li; Su, Feng-Juan; Ye, Cheng-Hui; Li, Jing; Lin, Yong-Cheng; Wang, Guang-Lei; Zeng, Jin-Sheng; Huang, Ru-Xun; Ou, Jing-Song; Sun, Hong-Shuo; Wang, Li-Ping; Pang, Ji-Yan; Pei, Zhong. 2012. "Marine Cyclotripeptide X-13 Promotes Angiogenesis in Zebrafish and Human Endothelial Cells via PI3K/Akt/eNOS Signaling Pathways." Mar. Drugs 10, no. 6: 1307-1320.


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