Mar. Drugs 2012, 10(6), 1307-1320; doi:10.3390/md10061307
Article

Marine Cyclotripeptide X-13 Promotes Angiogenesis in Zebrafish and Human Endothelial Cells via PI3K/Akt/eNOS Signaling Pathways

Received: 4 March 2012; in revised form: 8 May 2012 / Accepted: 29 May 2012 / Published: 7 June 2012
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: Cyclotripeptide X-13 is a core of novel marine compound xyloallenoide A isolated from mangrove fungus Xylaria sp. (no. 2508). We found that X-13 dose-dependently induced angiogenesis in zebrafish embryos and in human endothelial cells, which was accompanied by increased phosphorylation of eNOS and Akt and NO release. Inhibition of PI3K/Akt/eNOS by LY294002 or l-NAME suppressed X-13-induced angiogenesis. The present work demonstrates that X-13 promotes angiogenesis via PI3K/Akt/eNOS pathways.
Keywords: angiogenesis; marine cyclotripeptide; zebrafish; endothelial nitric oxide synthase; xyloallenoide A
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MDPI and ACS Style

Lu, X.-L.; Xu, Z.-L.; Yao, X.-L.; Su, F.-J.; Ye, C.-H.; Li, J.; Lin, Y.-C.; Wang, G.-L.; Zeng, J.-S.; Huang, R.-X.; Ou, J.-S.; Sun, H.-S.; Wang, L.-P.; Pang, J.-Y.; Pei, Z. Marine Cyclotripeptide X-13 Promotes Angiogenesis in Zebrafish and Human Endothelial Cells via PI3K/Akt/eNOS Signaling Pathways. Mar. Drugs 2012, 10, 1307-1320.

AMA Style

Lu X-L, Xu Z-L, Yao X-L, Su F-J, Ye C-H, Li J, Lin Y-C, Wang G-L, Zeng J-S, Huang R-X, Ou J-S, Sun H-S, Wang L-P, Pang J-Y, Pei Z. Marine Cyclotripeptide X-13 Promotes Angiogenesis in Zebrafish and Human Endothelial Cells via PI3K/Akt/eNOS Signaling Pathways. Marine Drugs. 2012; 10(6):1307-1320.

Chicago/Turabian Style

Lu, Xi-Lin; Xu, Zhong-Liang; Yao, Xiao-Li; Su, Feng-Juan; Ye, Cheng-Hui; Li, Jing; Lin, Yong-Cheng; Wang, Guang-Lei; Zeng, Jin-Sheng; Huang, Ru-Xun; Ou, Jing-Song; Sun, Hong-Shuo; Wang, Li-Ping; Pang, Ji-Yan; Pei, Zhong. 2012. "Marine Cyclotripeptide X-13 Promotes Angiogenesis in Zebrafish and Human Endothelial Cells via PI3K/Akt/eNOS Signaling Pathways." Mar. Drugs 10, no. 6: 1307-1320.

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