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Marine Cyclotripeptide X-13 Promotes Angiogenesis in Zebrafish and Human Endothelial Cells via PI3K/Akt/eNOS Signaling Pathways
Department of Neurology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou 510080, China
School of Chemistry & Chemical Engineering, Sun Yat-sen University, Guangzhou 510275, China
Department of Pharmacology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou 510080, China
Key Laboratory of Functional Molecules from Oceanic Microorganisms, Department of Education of Guangdong Province, Guangzhou 510080, China
Division of Cardiac Surgery, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou 510080, China
The Key Laboratory of Assisted Circulation, Ministry of Health, Guangzhou 510182, China
Division of Anatomy, Department of Surgery, Institute of Medical Science, Faculty of Medicine, University of Toronto, Toronto, ON M5G 1G6, Canada
Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, China
These authors contributed equally to this work.
* Authors to whom correspondence should be addressed.
Received: 4 March 2012; in revised form: 8 May 2012 / Accepted: 29 May 2012 / Published: 7 June 2012
Abstract: Cyclotripeptide X-13 is a core of novel marine compound xyloallenoide A isolated from mangrove fungus Xylaria sp. (no. 2508). We found that X-13 dose-dependently induced angiogenesis in zebrafish embryos and in human endothelial cells, which was accompanied by increased phosphorylation of eNOS and Akt and NO release. Inhibition of PI3K/Akt/eNOS by LY294002 or l-NAME suppressed X-13-induced angiogenesis. The present work demonstrates that X-13 promotes angiogenesis via PI3K/Akt/eNOS pathways.
Keywords: angiogenesis; marine cyclotripeptide; zebrafish; endothelial nitric oxide synthase; xyloallenoide A
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MDPI and ACS Style
Lu, X.-L.; Xu, Z.-L.; Yao, X.-L.; Su, F.-J.; Ye, C.-H.; Li, J.; Lin, Y.-C.; Wang, G.-L.; Zeng, J.-S.; Huang, R.-X.; Ou, J.-S.; Sun, H.-S.; Wang, L.-P.; Pang, J.-Y.; Pei, Z. Marine Cyclotripeptide X-13 Promotes Angiogenesis in Zebrafish and Human Endothelial Cells via PI3K/Akt/eNOS Signaling Pathways. Mar. Drugs 2012, 10, 1307-1320.
Lu X-L, Xu Z-L, Yao X-L, Su F-J, Ye C-H, Li J, Lin Y-C, Wang G-L, Zeng J-S, Huang R-X, Ou J-S, Sun H-S, Wang L-P, Pang J-Y, Pei Z. Marine Cyclotripeptide X-13 Promotes Angiogenesis in Zebrafish and Human Endothelial Cells via PI3K/Akt/eNOS Signaling Pathways. Marine Drugs. 2012; 10(6):1307-1320.
Lu, Xi-Lin; Xu, Zhong-Liang; Yao, Xiao-Li; Su, Feng-Juan; Ye, Cheng-Hui; Li, Jing; Lin, Yong-Cheng; Wang, Guang-Lei; Zeng, Jin-Sheng; Huang, Ru-Xun; Ou, Jing-Song; Sun, Hong-Shuo; Wang, Li-Ping; Pang, Ji-Yan; Pei, Zhong. 2012. "Marine Cyclotripeptide X-13 Promotes Angiogenesis in Zebrafish and Human Endothelial Cells via PI3K/Akt/eNOS Signaling Pathways." Mar. Drugs 10, no. 6: 1307-1320.