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Mar. Drugs 2012, 10(5), 1156-1168;

Briarenolides F and G, New Briarane Diterpenoids from a Briareum sp. Octocoral

Graduate Institute of Marine Biotechnology, National Dong Hwa University, Pingtung 944, Taiwan
National Museum of Marine Biology and Aquarium, Pingtung 944, Taiwan
Department of Marine Biotechnology and Resources and Division of Marine Biotechnology, Asia-Pacific Ocean Research Center, National Sun Yat-sen University, Kaohsiung 804, Taiwan
Graduate Institute of Natural Products, Chang Gung University, Taoyuan 333, Taiwan
Department of Life Science and Institute of Biotechnology, National Dong Hwa University, Hualien 974, Taiwan
Tsuzuki Institute for Traditional Medicine, China Medical University, Taichung 404, Taiwan
Authors to whom correspondence should be addressed.
Received: 19 April 2012 / Revised: 15 May 2012 / Accepted: 22 May 2012 / Published: 23 May 2012
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Two new briarane diterpenoids, briarenolides, F (1) and G (2), were isolated from an octocoral identified as Briareum sp. The structures of briaranes 1 and 2 were established by spectroscopic methods and by comparison of the spectroscopic data with those of known briarane analogues. Briarenolide F was proven to be the first 6-hydroperoxybriarane derivative and this compound displayed a significant inhibitory effect on the generation of superoxide anion by human neutrophils. View Full-Text
Keywords: briarenolide; briarane; Briareum; superoxide anion briarenolide; briarane; Briareum; superoxide anion

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Hong, P.-H.; Su, Y.-D.; Su, J.-H.; Chen, Y.-H.; Hwang, T.-L.; Weng, C.-F.; Lee, C.-H.; Wen, Z.-H.; Sheu, J.-H.; Lin, N.-C.; Kuo, Y.-H.; Sung, P.-J. Briarenolides F and G, New Briarane Diterpenoids from a Briareum sp. Octocoral. Mar. Drugs 2012, 10, 1156-1168.

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