Mar. Drugs 2012, 10(5), 1156-1168; doi:10.3390/md10051156
Article

Briarenolides F and G, New Briarane Diterpenoids from a Briareum sp. Octocoral

Pei-Han Hong 1,2 email, Yin-Di Su 2,3 email, Jui-Hsin Su 1,2,3 email, Yung-Husan Chen 2 email, Tsong-Long Hwang 4 email, Ching-Feng Weng 1,5 email, Chia-Hung Lee 1,5 email, Zhi-Hong Wen 3 email, Jyh-Horng Sheu 3 email, Nai-Cheng Lin 2 email, Yueh-Hsiung Kuo 6,* email and Ping-Jyun Sung 1,2,3,5,* email
1 Graduate Institute of Marine Biotechnology, National Dong Hwa University, Pingtung 944, Taiwan 2 National Museum of Marine Biology and Aquarium, Pingtung 944, Taiwan 3 Department of Marine Biotechnology and Resources and Division of Marine Biotechnology, Asia-Pacific Ocean Research Center, National Sun Yat-sen University, Kaohsiung 804, Taiwan 4 Graduate Institute of Natural Products, Chang Gung University, Taoyuan 333, Taiwan 5 Department of Life Science and Institute of Biotechnology, National Dong Hwa University, Hualien 974, Taiwan 6 Tsuzuki Institute for Traditional Medicine, China Medical University, Taichung 404, Taiwan
* Authors to whom correspondence should be addressed.
Received: 19 April 2012; in revised form: 15 May 2012 / Accepted: 22 May 2012 / Published: 23 May 2012
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Abstract: Two new briarane diterpenoids, briarenolides, F (1) and G (2), were isolated from an octocoral identified as Briareum sp. The structures of briaranes 1 and 2 were established by spectroscopic methods and by comparison of the spectroscopic data with those of known briarane analogues. Briarenolide F was proven to be the first 6-hydroperoxybriarane derivative and this compound displayed a significant inhibitory effect on the generation of superoxide anion by human neutrophils.
Keywords: briarenolide; briarane; Briareum; superoxide anion

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Cite This Article

MDPI and ACS Style

Hong, P.-H.; Su, Y.-D.; Su, J.-H.; Chen, Y.-H.; Hwang, T.-L.; Weng, C.-F.; Lee, C.-H.; Wen, Z.-H.; Sheu, J.-H.; Lin, N.-C.; Kuo, Y.-H.; Sung, P.-J. Briarenolides F and G, New Briarane Diterpenoids from a Briareum sp. Octocoral. Mar. Drugs 2012, 10, 1156-1168.

AMA Style

Hong P-H, Su Y-D, Su J-H, Chen Y-H, Hwang T-L, Weng C-F, Lee C-H, Wen Z-H, Sheu J-H, Lin N-C, Kuo Y-H, Sung P-J. Briarenolides F and G, New Briarane Diterpenoids from a Briareum sp. Octocoral. Marine Drugs. 2012; 10(5):1156-1168.

Chicago/Turabian Style

Hong, Pei-Han; Su, Yin-Di; Su, Jui-Hsin; Chen, Yung-Husan; Hwang, Tsong-Long; Weng, Ching-Feng; Lee, Chia-Hung; Wen, Zhi-Hong; Sheu, Jyh-Horng; Lin, Nai-Cheng; Kuo, Yueh-Hsiung; Sung, Ping-Jyun. 2012. "Briarenolides F and G, New Briarane Diterpenoids from a Briareum sp. Octocoral." Mar. Drugs 10, no. 5: 1156-1168.

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