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Mar. Drugs 2012, 10(5), 1156-1168; doi:10.3390/md10051156
Article

Briarenolides F and G, New Briarane Diterpenoids from a Briareum sp. Octocoral

1,2
,
2,3
,
1,2,3
,
2
,
4
,
1,5
,
1,5
,
3
,
3
,
2
,
6,*  and 1,2,3,5,*
1 Graduate Institute of Marine Biotechnology, National Dong Hwa University, Pingtung 944, Taiwan 2 National Museum of Marine Biology and Aquarium, Pingtung 944, Taiwan 3 Department of Marine Biotechnology and Resources and Division of Marine Biotechnology, Asia-Pacific Ocean Research Center, National Sun Yat-sen University, Kaohsiung 804, Taiwan 4 Graduate Institute of Natural Products, Chang Gung University, Taoyuan 333, Taiwan 5 Department of Life Science and Institute of Biotechnology, National Dong Hwa University, Hualien 974, Taiwan 6 Tsuzuki Institute for Traditional Medicine, China Medical University, Taichung 404, Taiwan
* Authors to whom correspondence should be addressed.
Received: 19 April 2012 / Revised: 15 May 2012 / Accepted: 22 May 2012 / Published: 23 May 2012
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Abstract

Two new briarane diterpenoids, briarenolides, F (1) and G (2), were isolated from an octocoral identified as Briareum sp. The structures of briaranes 1 and 2 were established by spectroscopic methods and by comparison of the spectroscopic data with those of known briarane analogues. Briarenolide F was proven to be the first 6-hydroperoxybriarane derivative and this compound displayed a significant inhibitory effect on the generation of superoxide anion by human neutrophils.
Keywords: briarenolide; briarane; Briareum; superoxide anion briarenolide; briarane; Briareum; superoxide anion
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).
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Hong, P.-H.; Su, Y.-D.; Su, J.-H.; Chen, Y.-H.; Hwang, T.-L.; Weng, C.-F.; Lee, C.-H.; Wen, Z.-H.; Sheu, J.-H.; Lin, N.-C.; Kuo, Y.-H.; Sung, P.-J. Briarenolides F and G, New Briarane Diterpenoids from a Briareum sp. Octocoral. Mar. Drugs 2012, 10, 1156-1168.

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