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Mar. Drugs 2012, 10(5), 1156-1168; doi:10.3390/md10051156

Briarenolides F and G, New Briarane Diterpenoids from a Briareum sp. Octocoral

, 2,3
, 1,2,3
, 2
, 4
, 1,5
, 1,5
, 3
, 3
, 2
, 6,*  and 1,2,3,5,*
1 Graduate Institute of Marine Biotechnology, National Dong Hwa University, Pingtung 944, Taiwan 2 National Museum of Marine Biology and Aquarium, Pingtung 944, Taiwan 3 Department of Marine Biotechnology and Resources and Division of Marine Biotechnology, Asia-Pacific Ocean Research Center, National Sun Yat-sen University, Kaohsiung 804, Taiwan 4 Graduate Institute of Natural Products, Chang Gung University, Taoyuan 333, Taiwan 5 Department of Life Science and Institute of Biotechnology, National Dong Hwa University, Hualien 974, Taiwan 6 Tsuzuki Institute for Traditional Medicine, China Medical University, Taichung 404, Taiwan
* Authors to whom correspondence should be addressed.
Received: 19 April 2012 / Revised: 15 May 2012 / Accepted: 22 May 2012 / Published: 23 May 2012
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Two new briarane diterpenoids, briarenolides, F (1) and G (2), were isolated from an octocoral identified as Briareum sp. The structures of briaranes 1 and 2 were established by spectroscopic methods and by comparison of the spectroscopic data with those of known briarane analogues. Briarenolide F was proven to be the first 6-hydroperoxybriarane derivative and this compound displayed a significant inhibitory effect on the generation of superoxide anion by human neutrophils.
Keywords: briarenolide; briarane; Briareum; superoxide anion briarenolide; briarane; Briareum; superoxide anion
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Hong, P.-H.; Su, Y.-D.; Su, J.-H.; Chen, Y.-H.; Hwang, T.-L.; Weng, C.-F.; Lee, C.-H.; Wen, Z.-H.; Sheu, J.-H.; Lin, N.-C.; Kuo, Y.-H.; Sung, P.-J. Briarenolides F and G, New Briarane Diterpenoids from a Briareum sp. Octocoral. Mar. Drugs 2012, 10, 1156-1168.

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