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Mar. Drugs 2012, 10(5), 1156-1168; doi:10.3390/md10051156
Article

Briarenolides F and G, New Briarane Diterpenoids from a Briareum sp. Octocoral

1,2
,
2,3
,
1,2,3
,
2
,
4
,
1,5
,
1,5
,
3
,
3
,
2
,
6,*  and 1,2,3,5,*
Received: 19 April 2012 / Revised: 15 May 2012 / Accepted: 22 May 2012 / Published: 23 May 2012
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Abstract

Two new briarane diterpenoids, briarenolides, F (1) and G (2), were isolated from an octocoral identified as Briareum sp. The structures of briaranes 1 and 2 were established by spectroscopic methods and by comparison of the spectroscopic data with those of known briarane analogues. Briarenolide F was proven to be the first 6-hydroperoxybriarane derivative and this compound displayed a significant inhibitory effect on the generation of superoxide anion by human neutrophils.
Keywords: briarenolide; briarane; Briareum; superoxide anion briarenolide; briarane; Briareum; superoxide anion
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Hong, P.-H.; Su, Y.-D.; Su, J.-H.; Chen, Y.-H.; Hwang, T.-L.; Weng, C.-F.; Lee, C.-H.; Wen, Z.-H.; Sheu, J.-H.; Lin, N.-C.; Kuo, Y.-H.; Sung, P.-J. Briarenolides F and G, New Briarane Diterpenoids from a Briareum sp. Octocoral. Mar. Drugs 2012, 10, 1156-1168.

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