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Bioactive Compounds from a Gorgonian Coral Echinomuricea sp. (Plexauridae)
AbstractA new labdane-type diterpenoid, echinolabdane A (1), and a new sterol, 6-epi-yonarasterol B (2), were isolated from a gorgonian coral identified as Echinomuricea sp. The structures of metabolites 1 and 2 were elucidated by spectroscopic methods. Echinolabdane A (1) possesses a novel tetracyclic skeleton with an oxepane ring jointed to an α,β-unsaturated-γ-lactone ring by a hemiketal moiety, and this compound is the first labdane-type diterpenoid to be obtained from marine organisms belonging to the phylum Cnidaria. 6-epi-Yonarasterol B (2) is the first steroid derivative to be isolated from gorgonian coral belonging to the genus Echinomuricea, and this compound displayed significant inhibitory effects on the generation of superoxide anions and the release of elastase by human neutrophils.
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Chung, H.-M.; Hong, P.-H.; Su, J.-H.; Hwang, T.-L.; Lu, M.-C.; Fang, L.-S.; Wu, Y.-C.; Li, J.-J.; Chen, J.-J.; Wang, W.-H.; Sung, P.-J. Bioactive Compounds from a Gorgonian Coral Echinomuricea sp. (Plexauridae). Mar. Drugs 2012, 10, 1169-1179.View more citation formats
Chung H-M, Hong P-H, Su J-H, Hwang T-L, Lu M-C, Fang L-S, Wu Y-C, Li J-J, Chen J-J, Wang W-H, Sung P-J. Bioactive Compounds from a Gorgonian Coral Echinomuricea sp. (Plexauridae). Marine Drugs. 2012; 10(5):1169-1179.Chicago/Turabian Style
Chung, Hsu-Ming; Hong, Pei-Han; Su, Jui-Hsin; Hwang, Tsong-Long; Lu, Mei-Chin; Fang, Lee-Shing; Wu, Yang-Chang; Li, Jan-Jung; Chen, Jih-Jung; Wang, Wei-Hsien; Sung, Ping-Jyun. 2012. "Bioactive Compounds from a Gorgonian Coral Echinomuricea sp. (Plexauridae)." Mar. Drugs 10, no. 5: 1169-1179.