Mar. Drugs 2012, 10(5), 1169-1179; doi:10.3390/md10051169
Article

Bioactive Compounds from a Gorgonian Coral Echinomuricea sp. (Plexauridae)

1 Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung 804, Taiwan 2 National Museum of Marine Biology and Aquarium, Pingtung 944, Taiwan 3 Graduate Institute of Marine Biotechnology, National Dong Hwa University, Pingtung 944, Taiwan 4 Division of Marine Biotechnology, Asia-Pacific Ocean Research Center, National Sun Yat-sen University, Kaohsiung 804, Taiwan 5 Graduate Institute of Natural Products, Chang Gung University, Taoyuan 333, Taiwan 6 Department of Sport, Health and Leisure, Cheng Shiu University, Kaohsiung 833, Taiwan 7 School of Chinese Medicine, College of Chinese Medicine, China Medical University, Taichung 404, Taiwan 8 Natural Medicinal Products Research Center, China Medical University Hospital, Taichung 404, Taiwan 9 Center for Molecular Medicine, China Medical University Hospital, Taichung 404, Taiwan 10 Department of Pharmacy and Graduate Institute of Pharmaceutical Technology, Tajen University, Pingtung 907, Taiwan 11 Department of Life Science and Institute of Biotechnology, National Dong Hwa University, Hualien 974, Taiwan
* Authors to whom correspondence should be addressed.
Received: 11 April 2012; in revised form: 9 May 2012 / Accepted: 21 May 2012 / Published: 23 May 2012
PDF Full-text Download PDF Full-Text [311 KB, uploaded 23 May 2012 13:30 CEST]
Abstract: A new labdane-type diterpenoid, echinolabdane A (1), and a new sterol, 6-epi-yonarasterol B (2), were isolated from a gorgonian coral identified as Echinomuricea sp. The structures of metabolites 1 and 2 were elucidated by spectroscopic methods. Echinolabdane A (1) possesses a novel tetracyclic skeleton with an oxepane ring jointed to an α,β-unsaturated-γ-lactone ring by a hemiketal moiety, and this compound is the first labdane-type diterpenoid to be obtained from marine organisms belonging to the phylum Cnidaria. 6-epi-Yonarasterol B (2) is the first steroid derivative to be isolated from gorgonian coral belonging to the genus Echinomuricea, and this compound displayed significant inhibitory effects on the generation of superoxide anions and the release of elastase by human neutrophils.
Keywords: Echinomuricea; echinolabdane; yonarasterol; superoxide anion; elastase

Article Statistics

Load and display the download statistics.

Citations to this Article

Cite This Article

MDPI and ACS Style

Chung, H.-M.; Hong, P.-H.; Su, J.-H.; Hwang, T.-L.; Lu, M.-C.; Fang, L.-S.; Wu, Y.-C.; Li, J.-J.; Chen, J.-J.; Wang, W.-H.; Sung, P.-J. Bioactive Compounds from a Gorgonian Coral Echinomuricea sp. (Plexauridae). Mar. Drugs 2012, 10, 1169-1179.

AMA Style

Chung H-M, Hong P-H, Su J-H, Hwang T-L, Lu M-C, Fang L-S, Wu Y-C, Li J-J, Chen J-J, Wang W-H, Sung P-J. Bioactive Compounds from a Gorgonian Coral Echinomuricea sp. (Plexauridae). Marine Drugs. 2012; 10(5):1169-1179.

Chicago/Turabian Style

Chung, Hsu-Ming; Hong, Pei-Han; Su, Jui-Hsin; Hwang, Tsong-Long; Lu, Mei-Chin; Fang, Lee-Shing; Wu, Yang-Chang; Li, Jan-Jung; Chen, Jih-Jung; Wang, Wei-Hsien; Sung, Ping-Jyun. 2012. "Bioactive Compounds from a Gorgonian Coral Echinomuricea sp. (Plexauridae)." Mar. Drugs 10, no. 5: 1169-1179.

Mar. Drugs EISSN 1660-3397 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert