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Mar. Drugs 2012, 10(5), 1169-1179; doi:10.3390/md10051169

Bioactive Compounds from a Gorgonian Coral Echinomuricea sp. (Plexauridae)

1
Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung 804, Taiwan
2
National Museum of Marine Biology and Aquarium, Pingtung 944, Taiwan
3
Graduate Institute of Marine Biotechnology, National Dong Hwa University, Pingtung 944, Taiwan
4
Division of Marine Biotechnology, Asia-Pacific Ocean Research Center, National Sun Yat-sen University, Kaohsiung 804, Taiwan
5
Graduate Institute of Natural Products, Chang Gung University, Taoyuan 333, Taiwan
6
Department of Sport, Health and Leisure, Cheng Shiu University, Kaohsiung 833, Taiwan
7
School of Chinese Medicine, College of Chinese Medicine, China Medical University, Taichung 404, Taiwan
8
Natural Medicinal Products Research Center, China Medical University Hospital, Taichung 404, Taiwan
9
Center for Molecular Medicine, China Medical University Hospital, Taichung 404, Taiwan
10
Department of Pharmacy and Graduate Institute of Pharmaceutical Technology, Tajen University, Pingtung 907, Taiwan
11
Department of Life Science and Institute of Biotechnology, National Dong Hwa University, Hualien 974, Taiwan
*
Authors to whom correspondence should be addressed.
Received: 11 April 2012 / Revised: 9 May 2012 / Accepted: 21 May 2012 / Published: 23 May 2012
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Abstract

A new labdane-type diterpenoid, echinolabdane A (1), and a new sterol, 6-epi-yonarasterol B (2), were isolated from a gorgonian coral identified as Echinomuricea sp. The structures of metabolites 1 and 2 were elucidated by spectroscopic methods. Echinolabdane A (1) possesses a novel tetracyclic skeleton with an oxepane ring jointed to an α,β-unsaturated-γ-lactone ring by a hemiketal moiety, and this compound is the first labdane-type diterpenoid to be obtained from marine organisms belonging to the phylum Cnidaria. 6-epi-Yonarasterol B (2) is the first steroid derivative to be isolated from gorgonian coral belonging to the genus Echinomuricea, and this compound displayed significant inhibitory effects on the generation of superoxide anions and the release of elastase by human neutrophils. View Full-Text
Keywords: Echinomuricea; echinolabdane; yonarasterol; superoxide anion; elastase Echinomuricea; echinolabdane; yonarasterol; superoxide anion; elastase
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Chung, H.-M.; Hong, P.-H.; Su, J.-H.; Hwang, T.-L.; Lu, M.-C.; Fang, L.-S.; Wu, Y.-C.; Li, J.-J.; Chen, J.-J.; Wang, W.-H.; Sung, P.-J. Bioactive Compounds from a Gorgonian Coral Echinomuricea sp. (Plexauridae). Mar. Drugs 2012, 10, 1169-1179.

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