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Mar. Drugs 2012, 10(5), 1169-1179; doi:10.3390/md10051169
Article

Bioactive Compounds from a Gorgonian Coral Echinomuricea sp. (Plexauridae)

1,2
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2,3
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10
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1,2,4,*  and 1,2,3,4,11,*
Received: 11 April 2012 / Revised: 9 May 2012 / Accepted: 21 May 2012 / Published: 23 May 2012
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Abstract

A new labdane-type diterpenoid, echinolabdane A (1), and a new sterol, 6-epi-yonarasterol B (2), were isolated from a gorgonian coral identified as Echinomuricea sp. The structures of metabolites 1 and 2 were elucidated by spectroscopic methods. Echinolabdane A (1) possesses a novel tetracyclic skeleton with an oxepane ring jointed to an α,β-unsaturated-γ-lactone ring by a hemiketal moiety, and this compound is the first labdane-type diterpenoid to be obtained from marine organisms belonging to the phylum Cnidaria. 6-epi-Yonarasterol B (2) is the first steroid derivative to be isolated from gorgonian coral belonging to the genus Echinomuricea, and this compound displayed significant inhibitory effects on the generation of superoxide anions and the release of elastase by human neutrophils.
Keywords: Echinomuricea; echinolabdane; yonarasterol; superoxide anion; elastase Echinomuricea; echinolabdane; yonarasterol; superoxide anion; elastase
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Chung, H.-M.; Hong, P.-H.; Su, J.-H.; Hwang, T.-L.; Lu, M.-C.; Fang, L.-S.; Wu, Y.-C.; Li, J.-J.; Chen, J.-J.; Wang, W.-H.; Sung, P.-J. Bioactive Compounds from a Gorgonian Coral Echinomuricea sp. (Plexauridae). Mar. Drugs 2012, 10, 1169-1179.

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