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Bioactive Compounds from a Gorgonian Coral Echinomuricea sp. (Plexauridae)
Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung 804, Taiwan
National Museum of Marine Biology and Aquarium, Pingtung 944, Taiwan
Graduate Institute of Marine Biotechnology, National Dong Hwa University, Pingtung 944, Taiwan
Division of Marine Biotechnology, Asia-Pacific Ocean Research Center, National Sun Yat-sen University, Kaohsiung 804, Taiwan
Graduate Institute of Natural Products, Chang Gung University, Taoyuan 333, Taiwan
Department of Sport, Health and Leisure, Cheng Shiu University, Kaohsiung 833, Taiwan
School of Chinese Medicine, College of Chinese Medicine, China Medical University, Taichung 404, Taiwan
Natural Medicinal Products Research Center, China Medical University Hospital, Taichung 404, Taiwan
Center for Molecular Medicine, China Medical University Hospital, Taichung 404, Taiwan
Department of Pharmacy and Graduate Institute of Pharmaceutical Technology, Tajen University, Pingtung 907, Taiwan
Department of Life Science and Institute of Biotechnology, National Dong Hwa University, Hualien 974, Taiwan
* Authors to whom correspondence should be addressed.
Received: 11 April 2012; in revised form: 9 May 2012 / Accepted: 21 May 2012 / Published: 23 May 2012
Abstract: A new labdane-type diterpenoid, echinolabdane A (1), and a new sterol, 6-epi-yonarasterol B (2), were isolated from a gorgonian coral identified as Echinomuricea sp. The structures of metabolites 1 and 2 were elucidated by spectroscopic methods. Echinolabdane A (1) possesses a novel tetracyclic skeleton with an oxepane ring jointed to an α,β-unsaturated-γ-lactone ring by a hemiketal moiety, and this compound is the first labdane-type diterpenoid to be obtained from marine organisms belonging to the phylum Cnidaria. 6-epi-Yonarasterol B (2) is the first steroid derivative to be isolated from gorgonian coral belonging to the genus Echinomuricea, and this compound displayed significant inhibitory effects on the generation of superoxide anions and the release of elastase by human neutrophils.
Keywords: Echinomuricea; echinolabdane; yonarasterol; superoxide anion; elastase
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Chung, H.-M.; Hong, P.-H.; Su, J.-H.; Hwang, T.-L.; Lu, M.-C.; Fang, L.-S.; Wu, Y.-C.; Li, J.-J.; Chen, J.-J.; Wang, W.-H.; Sung, P.-J. Bioactive Compounds from a Gorgonian Coral Echinomuricea sp. (Plexauridae). Mar. Drugs 2012, 10, 1169-1179.
Chung H-M, Hong P-H, Su J-H, Hwang T-L, Lu M-C, Fang L-S, Wu Y-C, Li J-J, Chen J-J, Wang W-H, Sung P-J. Bioactive Compounds from a Gorgonian Coral Echinomuricea sp. (Plexauridae). Marine Drugs. 2012; 10(5):1169-1179.
Chung, Hsu-Ming; Hong, Pei-Han; Su, Jui-Hsin; Hwang, Tsong-Long; Lu, Mei-Chin; Fang, Lee-Shing; Wu, Yang-Chang; Li, Jan-Jung; Chen, Jih-Jung; Wang, Wei-Hsien; Sung, Ping-Jyun. 2012. "Bioactive Compounds from a Gorgonian Coral Echinomuricea sp. (Plexauridae)." Mar. Drugs 10, no. 5: 1169-1179.