Mar. Drugs 2012, 10(5), 1092-1102; doi:10.3390/md10051092
Article

Structure Elucidation and Anticancer Activity of 7-Oxostaurosporine Derivatives from the Brazilian Endemic Tunicate Eudistoma vannamei

Paula Christine Jimenez 1,2 email, Diego Veras Wilke 2 email, Elthon Gois Ferreira 1 email, Renata Takeara 3 email, Manoel Odorico de Moraes 2 email, Edilberto Rocha Silveira 4 email, Tito Monteiro da Cruz Lotufo 1 email, Norberto Peporine Lopes 3 email and Leticia Veras Costa-Lotufo 1,2,* email
1 Institute of Marine Sciences, LABOMAR, Federal University of Ceará, Fortaleza, CE 60165-081, Brazil 2 Department of Physiology and Pharmacology, School of Medicine, Federal University of Ceará, Fortaleza, CE 60430-270, Brazil 3 Department of Chemistry and Physics, Faculty of Pharmaceutical Sciences of Ribeirão Preto, University of São Paulo, Ribeirão Preto, SP 14040-903, Brazil 4 Department of Organic and Inorganic Chemistry, Federal University of Ceará, Fortaleza, CE 60021-970, Brazil
* Author to whom correspondence should be addressed.
Received: 21 March 2012; in revised form: 11 May 2012 / Accepted: 11 May 2012 / Published: 21 May 2012
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Abstract: The present study reports the identification of two new staurosporine derivatives, 2-hydroxy-7-oxostaurosporine (1) and 3-hydroxy-7-oxostaurosporine (2), obtained from mid-polar fractions of an aqueous methanol extract of the tunicate Eudistoma vannamei, endemic to the northeast coast of Brazil. The mixture of 1 and 2 displayed IC50 values in the nM range and was up to 14 times more cytotoxic than staurosporine across a panel of tumor cell lines, as evaluated using the MTT assay.
Keywords: cell cycle arrest; ascidians; staurosporine

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Cite This Article

MDPI and ACS Style

Jimenez, P.C.; Wilke, D.V.; Ferreira, E.G.; Takeara, R.; de Moraes, M.O.; Silveira, E.R.; da Cruz Lotufo, T.M.; Lopes, N.P.; Costa-Lotufo, L.V. Structure Elucidation and Anticancer Activity of 7-Oxostaurosporine Derivatives from the Brazilian Endemic Tunicate Eudistoma vannamei. Mar. Drugs 2012, 10, 1092-1102.

AMA Style

Jimenez PC, Wilke DV, Ferreira EG, Takeara R, de Moraes MO, Silveira ER, da Cruz Lotufo TM, Lopes NP, Costa-Lotufo LV. Structure Elucidation and Anticancer Activity of 7-Oxostaurosporine Derivatives from the Brazilian Endemic Tunicate Eudistoma vannamei. Marine Drugs. 2012; 10(5):1092-1102.

Chicago/Turabian Style

Jimenez, Paula Christine; Wilke, Diego Veras; Ferreira, Elthon Gois; Takeara, Renata; de Moraes, Manoel Odorico; Silveira, Edilberto Rocha; da Cruz Lotufo, Tito Monteiro; Lopes, Norberto Peporine; Costa-Lotufo, Leticia Veras. 2012. "Structure Elucidation and Anticancer Activity of 7-Oxostaurosporine Derivatives from the Brazilian Endemic Tunicate Eudistoma vannamei." Mar. Drugs 10, no. 5: 1092-1102.

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