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Mar. Drugs 2012, 10(5), 1092-1102; doi:10.3390/md10051092
Article

Structure Elucidation and Anticancer Activity of 7-Oxostaurosporine Derivatives from the Brazilian Endemic Tunicate Eudistoma vannamei

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1 Institute of Marine Sciences, LABOMAR, Federal University of Ceará, Fortaleza, CE 60165-081, Brazil 2 Department of Physiology and Pharmacology, School of Medicine, Federal University of Ceará, Fortaleza, CE 60430-270, Brazil 3 Department of Chemistry and Physics, Faculty of Pharmaceutical Sciences of Ribeirão Preto, University of São Paulo, Ribeirão Preto, SP 14040-903, Brazil 4 Department of Organic and Inorganic Chemistry, Federal University of Ceará, Fortaleza, CE 60021-970, Brazil
* Author to whom correspondence should be addressed.
Received: 21 March 2012 / Revised: 11 May 2012 / Accepted: 11 May 2012 / Published: 21 May 2012
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Abstract

The present study reports the identification of two new staurosporine derivatives, 2-hydroxy-7-oxostaurosporine (1) and 3-hydroxy-7-oxostaurosporine (2), obtained from mid-polar fractions of an aqueous methanol extract of the tunicate Eudistoma vannamei, endemic to the northeast coast of Brazil. The mixture of 1 and 2 displayed IC50 values in the nM range and was up to 14 times more cytotoxic than staurosporine across a panel of tumor cell lines, as evaluated using the MTT assay.
Keywords: cell cycle arrest; ascidians; staurosporine cell cycle arrest; ascidians; staurosporine
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Jimenez, P.C.; Wilke, D.V.; Ferreira, E.G.; Takeara, R.; de Moraes, M.O.; Silveira, E.R.; da Cruz Lotufo, T.M.; Lopes, N.P.; Costa-Lotufo, L.V. Structure Elucidation and Anticancer Activity of 7-Oxostaurosporine Derivatives from the Brazilian Endemic Tunicate Eudistoma vannamei. Mar. Drugs 2012, 10, 1092-1102.

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