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Mar. Drugs 2012, 10(5), 1027-1036; doi:10.3390/md10051027
Article

Woodylides A–C, New Cytotoxic Linear Polyketides from the South China Sea Sponge Plakortis simplex

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Received: 3 February 2012 / Revised: 5 April 2012 / Accepted: 16 April 2012 / Published: 7 May 2012
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Abstract

Three new polyketides, woodylides A–C (13), were isolated from the ethanol extract of the South China Sea sponge Plakortis simplex. The structures were elucidated by spectroscopic data (IR, 1D and 2D NMR, and HRESIMS). The absolute configurations at C-3 of 1 and 3 were determined by the modified Mosher’s method. Antifungal, cytotoxic, and PTP1B inhibitory activities of these polyketides were evaluated. Compounds 1 and 3 showed antifungal activity against fungi Cryptococcus neoformans with IC50 values of 3.67 and 10.85 µg/mL, respectively. In the cytotoxicity test, compound 1 exhibited a moderate effect against the HeLa cell line with an IC50 value of 11.2 µg/mL, and compound 3 showed cytotoxic activity against the HCT-116 human colon tumor cell line and PTP1B inhibitory activity with IC50 values of 9.4 and 4.7 µg/mL, respectively.
Keywords: Plakortis simplex; woodylides; cytotoxicity; PTP1B inhibitory activity Plakortis simplex; woodylides; cytotoxicity; PTP1B inhibitory activity
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Yu, H.-B.; Liu, X.-F.; Xu, Y.; Gan, J.-H.; Jiao, W.-H.; Shen, Y.; Lin, H.-W. Woodylides A–C, New Cytotoxic Linear Polyketides from the South China Sea Sponge Plakortis simplex. Mar. Drugs 2012, 10, 1027-1036.

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