Woodylides A–C, New Cytotoxic Linear Polyketides from the South China Sea Sponge Plakortis simplex
AbstractThree new polyketides, woodylides A–C (1–3), were isolated from the ethanol extract of the South China Sea sponge Plakortis simplex. The structures were elucidated by spectroscopic data (IR, 1D and 2D NMR, and HRESIMS). The absolute configurations at C-3 of 1 and 3 were determined by the modified Mosher’s method. Antifungal, cytotoxic, and PTP1B inhibitory activities of these polyketides were evaluated. Compounds 1 and 3 showed antifungal activity against fungi Cryptococcus neoformans with IC50 values of 3.67 and 10.85 µg/mL, respectively. In the cytotoxicity test, compound 1 exhibited a moderate effect against the HeLa cell line with an IC50 value of 11.2 µg/mL, and compound 3 showed cytotoxic activity against the HCT-116 human colon tumor cell line and PTP1B inhibitory activity with IC50 values of 9.4 and 4.7 µg/mL, respectively.
- Supplementary File 1:
PDF-Document (PDF, 3766 KB)
Scifeed alert for new publicationsNever miss any articles matching your research from any publisher
- Get alerts for new papers matching your research
- Find out the new papers from selected authors
- Updated daily for 49'000+ journals and 6000+ publishers
- Define your Scifeed now
Yu, H.-B.; Liu, X.-F.; Xu, Y.; Gan, J.-H.; Jiao, W.-H.; Shen, Y.; Lin, H.-W. Woodylides A–C, New Cytotoxic Linear Polyketides from the South China Sea Sponge Plakortis simplex. Mar. Drugs 2012, 10, 1027-1036.
Yu H-B, Liu X-F, Xu Y, Gan J-H, Jiao W-H, Shen Y, Lin H-W. Woodylides A–C, New Cytotoxic Linear Polyketides from the South China Sea Sponge Plakortis simplex. Marine Drugs. 2012; 10(5):1027-1036.Chicago/Turabian Style
Yu, Hao-Bing; Liu, Xiang-Fang; Xu, Ying; Gan, Jian-Hong; Jiao, Wei-Hua; Shen, Yang; Lin, Hou-Wen. 2012. "Woodylides A–C, New Cytotoxic Linear Polyketides from the South China Sea Sponge Plakortis simplex." Mar. Drugs 10, no. 5: 1027-1036.