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Mar. Drugs 2012, 10(5), 1019-1026; doi:10.3390/md10051019
Article

Briacavatolides A–C, New Briaranes from the Taiwanese Octocoral Briareum excavatum

1
,
2,* , 3
 and
1,4,*
1 Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung 804, Taiwan 2 Department of Microbiology, Kaohsiung Medical University, Kaohsiung 807, Taiwan 3 Institute of Oceanography, National Taiwan University, Taipei 106, Taiwan 4 Asia-Pacific Ocean Research Center, National Sun Yat-sen University, Kaohsiung 804, Taiwan
* Authors to whom correspondence should be addressed.
Received: 13 March 2012 / Revised: 9 April 2012 / Accepted: 28 April 2012 / Published: 2 May 2012
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Abstract

In order to search for novel bioactive substances from marine organisms, we have investigated the organic extracts of the Taiwanese octocoral Briareum excavatum collected at Orchid Island. Three new briarane-type diterpenoids, briacavatolides A–C (13) as well as two known briaranes, briaexcavatolide U (4) and briaexcavatin L (5) were isolated from the acetone extract. The structures of these compounds were elucidated by extensive NMR spectroscopic analysis and physical data. The anti-HCMV (human cytomegalovirus) activity of 15 and their cytotoxicity against selected cancer cell lines were evaluated.
Keywords: Briareum excavatum; briarane-type diterpenoid; cytotoxicity; anti-HCMV Briareum excavatum; briarane-type diterpenoid; cytotoxicity; anti-HCMV
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Yeh, T.-T.; Wang, S.-K.; Dai, C.-F.; Duh, C.-Y. Briacavatolides A–C, New Briaranes from the Taiwanese Octocoral Briareum excavatum. Mar. Drugs 2012, 10, 1019-1026.

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