Briacavatolides A–C, New Briaranes from the Taiwanese Octocoral Briareum excavatum

doi:10.3390/md10051019

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Mar. Drugs 2012, 10(5), 1019-1026; doi:10.3390/md10051019

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Briacavatolides A–C, New Briaranes from the Taiwanese Octocoral Briareum excavatum

Tsun-Tai Yeh¹, Shang-Kwei Wang^2,* , Chang-Feng Dai³ and Chang-Yih Duh^1,4,*

¹ Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung 804, Taiwan ² Department of Microbiology, Kaohsiung Medical University, Kaohsiung 807, Taiwan ³ Institute of Oceanography, National Taiwan University, Taipei 106, Taiwan ⁴ Asia-Pacific Ocean Research Center, National Sun Yat-sen University, Kaohsiung 804, Taiwan

* Authors to whom correspondence should be addressed.

Received: 13 March 2012; in revised form: 9 April 2012 / Accepted: 28 April 2012 / Published: 2 May 2012

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Abstract: In order to search for novel bioactive substances from marine organisms, we have investigated the organic extracts of the Taiwanese octocoral Briareum excavatum collected at Orchid Island. Three new briarane-type diterpenoids, briacavatolides A–C (1–3) as well as two known briaranes, briaexcavatolide U (4) and briaexcavatin L (5) were isolated from the acetone extract. The structures of these compounds were elucidated by extensive NMR spectroscopic analysis and physical data. The anti-HCMV (human cytomegalovirus) activity of 1–5 and their cytotoxicity against selected cancer cell lines were evaluated.

Keywords: Briareum excavatum; briarane-type diterpenoid; cytotoxicity; anti-HCMV

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Cite This Article

MDPI and ACS Style

Yeh, T.-T.; Wang, S.-K.; Dai, C.-F.; Duh, C.-Y. Briacavatolides A–C, New Briaranes from the Taiwanese Octocoral Briareum excavatum. Mar. Drugs 2012, 10, 1019-1026.

AMA Style

Yeh T-T, Wang S-K, Dai C-F, Duh C-Y. Briacavatolides A–C, New Briaranes from the Taiwanese Octocoral Briareum excavatum. Marine Drugs. 2012; 10(5):1019-1026.

Chicago/Turabian Style

Yeh, Tsun-Tai; Wang, Shang-Kwei; Dai, Chang-Feng; Duh, Chang-Yih. 2012. "Briacavatolides A–C, New Briaranes from the Taiwanese Octocoral Briareum excavatum." Mar. Drugs 10, no. 5: 1019-1026.

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