Mar. Drugs 2012, 10(3), 617-626; doi:10.3390/md10030617
Article

Sarcocrassocolides M–O, Bioactive Cembranoids from the Dongsha Atoll Soft Coral Sarcophyton crassocaule

Wan-Yu Lin 1 email, Yi Lu 1 email, Bo-Wei Chen 1 email, Chiung-Yao Huang 1 email, Jui-Hsin Su 2,3 email, Zhi-Hong Wen 1 email, Chang-Feng Dai 4 email, Yao-Haur Kuo 5 email and Jyh-Horng Sheu 1,6,* email
1 Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung 804, Taiwan 2 National Museum of Marine Biology & Aquarium, Pingtung 944, Taiwan 3 Graduate Institute of Marine Biotechnology, National Dong Hwa University, Pingtung 944, Taiwan 4 Institute of Oceanography, National Taiwan University, Taipei 112, Taiwan 5 National Research Institute of Chinese Medicine, Taipei 112, Taiwan 6 Asia-Pacific Ocean Research Center, National Sun Yat-sen University, Kaohsiung 804, Taiwan
* Author to whom correspondence should be addressed.
Received: 23 November 2011; in revised form: 29 February 2012 / Accepted: 29 February 2012 / Published: 8 March 2012
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Abstract: Three new cembranoids, sarcocrassocolides M–O (1–3), have been isolated from the soft coral Sarcophyton crassocaule. The structures of the metabolites were determined by extensive spectroscopic analysis. Compounds 1–3 were shown to exhibit moderate cytotoxicity toward a limited panel of cancer cell lines and display significant in vitro anti-inflammatory activity in LPS-stimulated RAW264.7 macrophage cells by inhibiting the expression of the iNOS protein.
Keywords: soft coral; Sarcophyton crassocaule; cytotoxic activity; anti-inflammatory activity

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Cite This Article

MDPI and ACS Style

Lin, W.-Y.; Lu, Y.; Chen, B.-W.; Huang, C.-Y.; Su, J.-H.; Wen, Z.-H.; Dai, C.-F.; Kuo, Y.-H.; Sheu, J.-H. Sarcocrassocolides M–O, Bioactive Cembranoids from the Dongsha Atoll Soft Coral Sarcophyton crassocaule. Mar. Drugs 2012, 10, 617-626.

AMA Style

Lin W-Y, Lu Y, Chen B-W, Huang C-Y, Su J-H, Wen Z-H, Dai C-F, Kuo Y-H, Sheu J-H. Sarcocrassocolides M–O, Bioactive Cembranoids from the Dongsha Atoll Soft Coral Sarcophyton crassocaule. Marine Drugs. 2012; 10(3):617-626.

Chicago/Turabian Style

Lin, Wan-Yu; Lu, Yi; Chen, Bo-Wei; Huang, Chiung-Yao; Su, Jui-Hsin; Wen, Zhi-Hong; Dai, Chang-Feng; Kuo, Yao-Haur; Sheu, Jyh-Horng. 2012. "Sarcocrassocolides M–O, Bioactive Cembranoids from the Dongsha Atoll Soft Coral Sarcophyton crassocaule." Mar. Drugs 10, no. 3: 617-626.

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