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Mar. Drugs 2012, 10(3), 627-638; doi:10.3390/md10030627
Article

Chondrosterins A–E, Triquinane-Type Sesquiterpenoids from Soft Coral-Associated Fungus Chondrostereum sp.

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1 School of Chemistry and Chemical Engineering, Sun Yat-sen University, Guangzhou 510275, China 2 School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, China
* Author to whom correspondence should be addressed.
Received: 6 February 2012 / Revised: 5 March 2012 / Accepted: 5 March 2012 / Published: 13 March 2012
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Abstract

The marine fungus Chondrostereum sp. was collected from a soft coral Sarcophyton tortuosum from the South China Sea. This fungus was cultured in potato dextrose broth medium and the culture broth was extracted with EtOAc. Five new triquinane-type sesquiterpenoids, chondrosterins A–E (15), and the known sesquiterpenoid hirsutanol C (6), were isolated. The structures were elucidated mainly on the basis of NMR, MS, and X-ray single-crystal diffraction data. Chondrosterin A (1) showed significant cytotoxic activities against cancer lines A549, CNE2, and LoVo with IC50 values of 2.45, 4.95, and 5.47 μM, respectively.
Keywords: Chondrostereum sp.; sesquiterpenoids; chondrosterins; marine fungus; cytotoxic activities Chondrostereum sp.; sesquiterpenoids; chondrosterins; marine fungus; cytotoxic activities
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Li, H.-J.; Xie, Y.-L.; Xie, Z.-L.; Chen, Y.; Lam, C.-K.; Lan, W.-J. Chondrosterins A–E, Triquinane-Type Sesquiterpenoids from Soft Coral-Associated Fungus Chondrostereum sp.. Mar. Drugs 2012, 10, 627-638.

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