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Mar. Drugs 2012, 10(3), 627-638; doi:10.3390/md10030627
Article

Chondrosterins A–E, Triquinane-Type Sesquiterpenoids from Soft Coral-Associated Fungus Chondrostereum sp.

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Received: 6 February 2012; in revised form: 5 March 2012 / Accepted: 5 March 2012 / Published: 13 March 2012
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Abstract: The marine fungus Chondrostereum sp. was collected from a soft coral Sarcophyton tortuosum from the South China Sea. This fungus was cultured in potato dextrose broth medium and the culture broth was extracted with EtOAc. Five new triquinane-type sesquiterpenoids, chondrosterins A–E (15), and the known sesquiterpenoid hirsutanol C (6), were isolated. The structures were elucidated mainly on the basis of NMR, MS, and X-ray single-crystal diffraction data. Chondrosterin A (1) showed significant cytotoxic activities against cancer lines A549, CNE2, and LoVo with IC50 values of 2.45, 4.95, and 5.47 μM, respectively.
Keywords: Chondrostereum sp.; sesquiterpenoids; chondrosterins; marine fungus; cytotoxic activities Chondrostereum sp.; sesquiterpenoids; chondrosterins; marine fungus; cytotoxic activities
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Li, H.-J.; Xie, Y.-L.; Xie, Z.-L.; Chen, Y.; Lam, C.-K.; Lan, W.-J. Chondrosterins A–E, Triquinane-Type Sesquiterpenoids from Soft Coral-Associated Fungus Chondrostereum sp.. Mar. Drugs 2012, 10, 627-638.

AMA Style

Li H-J, Xie Y-L, Xie Z-L, Chen Y, Lam C-K, Lan W-J. Chondrosterins A–E, Triquinane-Type Sesquiterpenoids from Soft Coral-Associated Fungus Chondrostereum sp.. Marine Drugs. 2012; 10(3):627-638.

Chicago/Turabian Style

Li, Hou-Jin; Xie, Ying-Lu; Xie, Zhong-Liang; Chen, Ying; Lam, Chi-Keung; Lan, Wen-Jian. 2012. "Chondrosterins A–E, Triquinane-Type Sesquiterpenoids from Soft Coral-Associated Fungus Chondrostereum sp.." Mar. Drugs 10, no. 3: 627-638.


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