Mar. Drugs 2012, 10(3), 627-638; doi:10.3390/md10030627
Article

Chondrosterins A–E, Triquinane-Type Sesquiterpenoids from Soft Coral-Associated Fungus Chondrostereum sp.

1 School of Chemistry and Chemical Engineering, Sun Yat-sen University, Guangzhou 510275, China 2 School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, China
* Author to whom correspondence should be addressed.
Received: 6 February 2012; in revised form: 5 March 2012 / Accepted: 5 March 2012 / Published: 13 March 2012
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Abstract: The marine fungus Chondrostereum sp. was collected from a soft coral Sarcophyton tortuosum from the South China Sea. This fungus was cultured in potato dextrose broth medium and the culture broth was extracted with EtOAc. Five new triquinane-type sesquiterpenoids, chondrosterins A–E (15), and the known sesquiterpenoid hirsutanol C (6), were isolated. The structures were elucidated mainly on the basis of NMR, MS, and X-ray single-crystal diffraction data. Chondrosterin A (1) showed significant cytotoxic activities against cancer lines A549, CNE2, and LoVo with IC50 values of 2.45, 4.95, and 5.47 μM, respectively.
Keywords: Chondrostereum sp.; sesquiterpenoids; chondrosterins; marine fungus; cytotoxic activities

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MDPI and ACS Style

Li, H.-J.; Xie, Y.-L.; Xie, Z.-L.; Chen, Y.; Lam, C.-K.; Lan, W.-J. Chondrosterins A–E, Triquinane-Type Sesquiterpenoids from Soft Coral-Associated Fungus Chondrostereum sp.. Mar. Drugs 2012, 10, 627-638.

AMA Style

Li H-J, Xie Y-L, Xie Z-L, Chen Y, Lam C-K, Lan W-J. Chondrosterins A–E, Triquinane-Type Sesquiterpenoids from Soft Coral-Associated Fungus Chondrostereum sp.. Marine Drugs. 2012; 10(3):627-638.

Chicago/Turabian Style

Li, Hou-Jin; Xie, Ying-Lu; Xie, Zhong-Liang; Chen, Ying; Lam, Chi-Keung; Lan, Wen-Jian. 2012. "Chondrosterins A–E, Triquinane-Type Sesquiterpenoids from Soft Coral-Associated Fungus Chondrostereum sp.." Mar. Drugs 10, no. 3: 627-638.

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