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Mar. Drugs 2012, 10(3), 598-603; doi:10.3390/md10030598

Article

A Fatty Acid Glycoside from a Marine-Derived Fungus Isolated from Mangrove Plant Scyphiphora hydrophyllacea

Yan-Bo Zeng ^1,2,† , Hui Wang ^1,2,† , Wen-Jian Zuo ^1,2 , Bo Zheng ^1,2 , Tao Yang ¹ , Hao-Fu Dai ^1,2,*  and Wen-Li Mei ^1,2,*

¹ Hainan Key Laboratory for Research and Development of Natural Products from Li Folk Medicine, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou 571101, Hainan, China ² Haikou Key Laboratory for Research and Development of Tropical Natural Products, Haikou 571101, Hainan, China ^† These authors contributed equally to this work.

* Authors to whom correspondence should be addressed.

Received: 16 January 2012; in revised form: 14 February 2012 / Accepted: 1 March 2012 / Published: 6 March 2012

Download PDF Full-Text [184 KB, uploaded 6 March 2012 13:50 CET]

Abstract: To study the antimicrobial components from the endophytic fungus A1 of mangrove plant Scyphiphora hydrophyllacea Gaertn. F., a new fatty acid glucoside was isolated by column chromatography from the broth of A1, and its structure was identified as R-3-hydroxyundecanoic acid methylester-3-O-α-l-rhamnopyranoside (1) by spectroscopic methods including 1D and 2D NMR (HMQC, ¹H-¹H COSY and HMBC) and chemical methods. Antimicrobial assay showed compound 1 possessed modest inhibitory effect on Saphylococcus aureus and methicillin-resistant S. aureus (MRSA) using the filter paper disc agar diffusion method.

Keywords: marine endophyte; secondary metabolite; Scyphiphora hydrophyllacea; R-3-hydroxyundecanoic acid methylester-3-O-α-l-rhamnopyranoside

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