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Mar. Drugs 2012, 10(2), 340-348; doi:10.3390/md10020340
Article

Four Eremophilane Sesquiterpenes from the Mangrove Endophytic Fungus Xylaria sp. BL321

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Received: 2 December 2011 / Revised: 17 January 2012 / Accepted: 17 January 2012 / Published: 6 February 2012
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Abstract

Three new eremophilane sesquiterpenes (13) were isolated from the mangrove endophytic fungus Xylaria sp. BL321 together with 07H239-A (4), a known analogue of the new compounds. The structures of these compounds were elucidated by analysis of their MS, 1D and 2D NMR spectroscopic data. Compound 4 showed activation activity on α-glucosidase at 0.15 μM (146%), and then, 4 gradually produced inhibitory activity on α-glucosidase with increasing concentration, and the IC50 value is 6.54 μM.
Keywords: marine fungus; Xylaria sp.; mangrove; sesquiterpenes; α-glucosidase marine fungus; Xylaria sp.; mangrove; sesquiterpenes; α-glucosidase
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Song, Y.; Wang, J.; Huang, H.; Ma, L.; Wang, J.; Gu, Y.; Liu, L.; Lin, Y. Four Eremophilane Sesquiterpenes from the Mangrove Endophytic Fungus Xylaria sp. BL321. Mar. Drugs 2012, 10, 340-348.

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