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Mar. Drugs 2012, 10(12), 2817-2825; doi:10.3390/md10122817
Article

Sesquiterpene and Acetogenin Derivatives from the Marine Red Alga Laurencia okamurai

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Key Laboratory of Experimental Marine Biology, Institute of Oceanology, Chinese Academy of Sciences, Nanhai Road 7, Qingdao 266071, China
* Author to whom correspondence should be addressed.
Received: 16 November 2012 / Revised: 8 December 2012 / Accepted: 10 December 2012 / Published: 14 December 2012
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Abstract

In addition to 13 known compounds, four new bisabolane sesquiterpenes, okamurenes A–D (14), a new chamigrane derivative, okamurene E (5), and a new C12-acetogenin, okamuragenin (6), were isolated from the marine red alga Laurencia okamurai. The structures of these compounds were determined through detailed spectroscopic analyses. Of these, okamurenes A and B (1 and 2) are the first examples of bromobisabolane sesquiterpenes possessing a phenyl moiety among Laurencia-derived sesquiterpenes, while okamuragenin (6) was the first acetogenin aldehyde possessing a C12-carbon skeleton. Each of the isolated compounds was evaluated for the brine shrimp (Artemia salina) lethal assay and 7-hydroxylaurene displayed potent lethality with LD50 1.8 μM.
Keywords: marine alga; Laurencia okamurai; bisabolane sesquiterpene; C12-acetogenin; brine shrimp lethality marine alga; Laurencia okamurai; bisabolane sesquiterpene; C12-acetogenin; brine shrimp lethality
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).
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Liang, Y.; Li, X.-M.; Cui, C.-M.; Li, C.-S.; Sun, H.; Wang, B.-G. Sesquiterpene and Acetogenin Derivatives from the Marine Red Alga Laurencia okamurai. Mar. Drugs 2012, 10, 2817-2825.

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