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Mar. Drugs 2012, 10(12), 2817-2825; doi:10.3390/md10122817

Sesquiterpene and Acetogenin Derivatives from the Marine Red Alga Laurencia okamurai

Key Laboratory of Experimental Marine Biology, Institute of Oceanology, Chinese Academy of Sciences, Nanhai Road 7, Qingdao 266071, China
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Received: 16 November 2012 / Revised: 8 December 2012 / Accepted: 10 December 2012 / Published: 14 December 2012
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Abstract

In addition to 13 known compounds, four new bisabolane sesquiterpenes, okamurenes A–D (14), a new chamigrane derivative, okamurene E (5), and a new C12-acetogenin, okamuragenin (6), were isolated from the marine red alga Laurencia okamurai. The structures of these compounds were determined through detailed spectroscopic analyses. Of these, okamurenes A and B (1 and 2) are the first examples of bromobisabolane sesquiterpenes possessing a phenyl moiety among Laurencia-derived sesquiterpenes, while okamuragenin (6) was the first acetogenin aldehyde possessing a C12-carbon skeleton. Each of the isolated compounds was evaluated for the brine shrimp (Artemia salina) lethal assay and 7-hydroxylaurene displayed potent lethality with LD50 1.8 μM.
Keywords: marine alga; Laurencia okamurai; bisabolane sesquiterpene; C12-acetogenin; brine shrimp lethality marine alga; Laurencia okamurai; bisabolane sesquiterpene; C12-acetogenin; brine shrimp lethality
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MDPI and ACS Style

Liang, Y.; Li, X.-M.; Cui, C.-M.; Li, C.-S.; Sun, H.; Wang, B.-G. Sesquiterpene and Acetogenin Derivatives from the Marine Red Alga Laurencia okamurai. Mar. Drugs 2012, 10, 2817-2825.

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