This article is
- freely available
Sesquiterpene and Acetogenin Derivatives from the Marine Red Alga Laurencia okamurai
Key Laboratory of Experimental Marine Biology, Institute of Oceanology, Chinese Academy of Sciences, Nanhai Road 7, Qingdao 266071, China
* Author to whom correspondence should be addressed.
Received: 16 November 2012; in revised form: 8 December 2012 / Accepted: 10 December 2012 / Published: 14 December 2012
Abstract: In addition to 13 known compounds, four new bisabolane sesquiterpenes, okamurenes A–D (1–4), a new chamigrane derivative, okamurene E (5), and a new C12-acetogenin, okamuragenin (6), were isolated from the marine red alga Laurencia okamurai. The structures of these compounds were determined through detailed spectroscopic analyses. Of these, okamurenes A and B (1 and 2) are the first examples of bromobisabolane sesquiterpenes possessing a phenyl moiety among Laurencia-derived sesquiterpenes, while okamuragenin (6) was the first acetogenin aldehyde possessing a C12-carbon skeleton. Each of the isolated compounds was evaluated for the brine shrimp (Artemia salina) lethal assay and 7-hydroxylaurene displayed potent lethality with LD50 1.8 μM.
Keywords: marine alga; Laurencia okamurai; bisabolane sesquiterpene; C12-acetogenin; brine shrimp lethality
Article StatisticsClick here to load and display the download statistics.
Notes: Multiple requests from the same IP address are counted as one view.
Cite This Article
MDPI and ACS Style
Liang, Y.; Li, X.-M.; Cui, C.-M.; Li, C.-S.; Sun, H.; Wang, B.-G. Sesquiterpene and Acetogenin Derivatives from the Marine Red Alga Laurencia okamurai. Mar. Drugs 2012, 10, 2817-2825.
Liang Y, Li X-M, Cui C-M, Li C-S, Sun H, Wang B-G. Sesquiterpene and Acetogenin Derivatives from the Marine Red Alga Laurencia okamurai. Marine Drugs. 2012; 10(12):2817-2825.
Liang, Yi; Li, Xiao-Ming; Cui, Chuan-Ming; Li, Chun-Shun; Sun, Hong; Wang, Bin-Gui. 2012. "Sesquiterpene and Acetogenin Derivatives from the Marine Red Alga Laurencia okamurai." Mar. Drugs 10, no. 12: 2817-2825.