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Sesquiterpene and Acetogenin Derivatives from the Marine Red Alga Laurencia okamurai
Key Laboratory of Experimental Marine Biology, Institute of Oceanology, Chinese Academy of Sciences, Nanhai Road 7, Qingdao 266071, China
* Author to whom correspondence should be addressed.
Received: 16 November 2012; in revised form: 8 December 2012 / Accepted: 10 December 2012 / Published: 14 December 2012
Abstract: In addition to 13 known compounds, four new bisabolane sesquiterpenes, okamurenes A–D (1–4), a new chamigrane derivative, okamurene E (5), and a new C12-acetogenin, okamuragenin (6), were isolated from the marine red alga Laurencia okamurai. The structures of these compounds were determined through detailed spectroscopic analyses. Of these, okamurenes A and B (1 and 2) are the first examples of bromobisabolane sesquiterpenes possessing a phenyl moiety among Laurencia-derived sesquiterpenes, while okamuragenin (6) was the first acetogenin aldehyde possessing a C12-carbon skeleton. Each of the isolated compounds was evaluated for the brine shrimp (Artemia salina) lethal assay and 7-hydroxylaurene displayed potent lethality with LD50 1.8 μM.
Keywords: marine alga; Laurencia okamurai; bisabolane sesquiterpene; C12-acetogenin; brine shrimp lethality
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Liang, Y.; Li, X.-M.; Cui, C.-M.; Li, C.-S.; Sun, H.; Wang, B.-G. Sesquiterpene and Acetogenin Derivatives from the Marine Red Alga Laurencia okamurai. Mar. Drugs 2012, 10, 2817-2825.
Liang Y, Li X-M, Cui C-M, Li C-S, Sun H, Wang B-G. Sesquiterpene and Acetogenin Derivatives from the Marine Red Alga Laurencia okamurai. Marine Drugs. 2012; 10(12):2817-2825.
Liang, Yi; Li, Xiao-Ming; Cui, Chuan-Ming; Li, Chun-Shun; Sun, Hong; Wang, Bin-Gui. 2012. "Sesquiterpene and Acetogenin Derivatives from the Marine Red Alga Laurencia okamurai." Mar. Drugs 10, no. 12: 2817-2825.