Mar. Drugs 2012, 10(12), 2817-2825; doi:10.3390/md10122817
Article

Sesquiterpene and Acetogenin Derivatives from the Marine Red Alga Laurencia okamurai

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Received: 16 November 2012; in revised form: 8 December 2012 / Accepted: 10 December 2012 / Published: 14 December 2012
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: In addition to 13 known compounds, four new bisabolane sesquiterpenes, okamurenes A–D (14), a new chamigrane derivative, okamurene E (5), and a new C12-acetogenin, okamuragenin (6), were isolated from the marine red alga Laurencia okamurai. The structures of these compounds were determined through detailed spectroscopic analyses. Of these, okamurenes A and B (1 and 2) are the first examples of bromobisabolane sesquiterpenes possessing a phenyl moiety among Laurencia-derived sesquiterpenes, while okamuragenin (6) was the first acetogenin aldehyde possessing a C12-carbon skeleton. Each of the isolated compounds was evaluated for the brine shrimp (Artemia salina) lethal assay and 7-hydroxylaurene displayed potent lethality with LD50 1.8 μM.
Keywords: marine alga; Laurencia okamurai; bisabolane sesquiterpene; C12-acetogenin; brine shrimp lethality
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MDPI and ACS Style

Liang, Y.; Li, X.-M.; Cui, C.-M.; Li, C.-S.; Sun, H.; Wang, B.-G. Sesquiterpene and Acetogenin Derivatives from the Marine Red Alga Laurencia okamurai. Mar. Drugs 2012, 10, 2817-2825.

AMA Style

Liang Y, Li X-M, Cui C-M, Li C-S, Sun H, Wang B-G. Sesquiterpene and Acetogenin Derivatives from the Marine Red Alga Laurencia okamurai. Marine Drugs. 2012; 10(12):2817-2825.

Chicago/Turabian Style

Liang, Yi; Li, Xiao-Ming; Cui, Chuan-Ming; Li, Chun-Shun; Sun, Hong; Wang, Bin-Gui. 2012. "Sesquiterpene and Acetogenin Derivatives from the Marine Red Alga Laurencia okamurai." Mar. Drugs 10, no. 12: 2817-2825.

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