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Mar. Drugs 2012, 10(12), 2691-2697; doi:10.3390/md10122691
Article

A New Dibenz[b,e]oxepine Derivative, 1-Hydroxy-10-methoxy-dibenz[b,e]oxepin-6,11-dione, from a Marine-Derived Fungus, Beauveria bassiana TPU942

1
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1,2
,
1
,
1
,
1
,
1
 and
1,*
1 Department of Natural Product Chemistry, Tohoku Pharmaceutical University, Sendai 981-8558, Japan 2 Faculty of Agriculture, Indonesia Development University, Manado 95361, Indonesia
* Author to whom correspondence should be addressed.
Received: 28 September 2012 / Revised: 19 October 2012 / Accepted: 14 November 2012 / Published: 27 November 2012
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Abstract

1-Hydroxy-10-methoxy-dibenz[b,e]oxepin-6,11-dione (1) was obtained from the culture broth of a marine-derived fungus, Beauveria bassiana TPU942, isolated from a marine sponge collected at Iriomote Island in Okinawa, together with two known compounds, chrysazin (2) and globosuxanthone A (3). The structure of 1 was elucidated on the basis of its spectroscopic data (HREIMS, 1D and 2D NMR experiments including 1H–1H COSY, HMQC and HMBC spectra). Dibenz[b,e]oxepines are rare in nature, and only six natural products have been reported. Therefore, compound 1 is the seventh natural product in this class. Compounds 2 and 3 showed an antifungal activity against Candida albicans, and 3 inhibited the cell growth against two human cancer cell lines, HCT-15 (colon) and Jurkat (T-cell lymphoma). Compound 1 did not show an apparent activity in the same bioassays.
Keywords: dibenzooxepine derivative; 1-hydroxy-10-methoxy-dibenz[b,e]oxepin-6,11-dione; marine-derived fungus; fungal metabolites dibenzooxepine derivative; 1-hydroxy-10-methoxy-dibenz[b,e]oxepin-6,11-dione; marine-derived fungus; fungal metabolites
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Yamazaki, H.; Rotinsulu, H.; Kaneko, T.; Murakami, K.; Fujiwara, H.; Ukai, K.; Namikoshi, M. A New Dibenz[b,e]oxepine Derivative, 1-Hydroxy-10-methoxy-dibenz[b,e]oxepin-6,11-dione, from a Marine-Derived Fungus, Beauveria bassiana TPU942. Mar. Drugs 2012, 10, 2691-2697.

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