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Mar. Drugs 2012, 10(12), 2691-2697; doi:10.3390/md10122691
Article

A New Dibenz[b,e]oxepine Derivative, 1-Hydroxy-10-methoxy-dibenz[b,e]oxepin-6,11-dione, from a Marine-Derived Fungus, Beauveria bassiana TPU942

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Received: 28 September 2012; in revised form: 19 October 2012 / Accepted: 14 November 2012 / Published: 27 November 2012
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Abstract: 1-Hydroxy-10-methoxy-dibenz[b,e]oxepin-6,11-dione (1) was obtained from the culture broth of a marine-derived fungus, Beauveria bassiana TPU942, isolated from a marine sponge collected at Iriomote Island in Okinawa, together with two known compounds, chrysazin (2) and globosuxanthone A (3). The structure of 1 was elucidated on the basis of its spectroscopic data (HREIMS, 1D and 2D NMR experiments including 1H–1H COSY, HMQC and HMBC spectra). Dibenz[b,e]oxepines are rare in nature, and only six natural products have been reported. Therefore, compound 1 is the seventh natural product in this class. Compounds 2 and 3 showed an antifungal activity against Candida albicans, and 3 inhibited the cell growth against two human cancer cell lines, HCT-15 (colon) and Jurkat (T-cell lymphoma). Compound 1 did not show an apparent activity in the same bioassays.
Keywords: dibenzooxepine derivative; 1-hydroxy-10-methoxy-dibenz[b,e]oxepin-6,11-dione; marine-derived fungus; fungal metabolites dibenzooxepine derivative; 1-hydroxy-10-methoxy-dibenz[b,e]oxepin-6,11-dione; marine-derived fungus; fungal metabolites
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Yamazaki, H.; Rotinsulu, H.; Kaneko, T.; Murakami, K.; Fujiwara, H.; Ukai, K.; Namikoshi, M. A New Dibenz[b,e]oxepine Derivative, 1-Hydroxy-10-methoxy-dibenz[b,e]oxepin-6,11-dione, from a Marine-Derived Fungus, Beauveria bassiana TPU942. Mar. Drugs 2012, 10, 2691-2697.

AMA Style

Yamazaki H, Rotinsulu H, Kaneko T, Murakami K, Fujiwara H, Ukai K, Namikoshi M. A New Dibenz[b,e]oxepine Derivative, 1-Hydroxy-10-methoxy-dibenz[b,e]oxepin-6,11-dione, from a Marine-Derived Fungus, Beauveria bassiana TPU942. Marine Drugs. 2012; 10(12):2691-2697.

Chicago/Turabian Style

Yamazaki, Hiroyuki; Rotinsulu, Henki; Kaneko, Tsuyoshi; Murakami, Kazuki; Fujiwara, Hiromu; Ukai, Kazuyo; Namikoshi, Michio. 2012. "A New Dibenz[b,e]oxepine Derivative, 1-Hydroxy-10-methoxy-dibenz[b,e]oxepin-6,11-dione, from a Marine-Derived Fungus, Beauveria bassiana TPU942." Mar. Drugs 10, no. 12: 2691-2697.


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