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Mar. Drugs 2012, 10(12), 2648-2660; doi:10.3390/md10122648
Article

Adjuvant Activity of Sargassum pallidum Polysaccharides against Combined Newcastle Disease, Infectious Bronchitis and Avian Influenza Inactivated Vaccines

1,2,* , 2
,
1,* , 2
,
2
 and
2
1 School of Medicinal and Pharmacy, Ocean University of China, 5 Yushan Road, Qingdao, Shandong 266003, China 2 Shandong Sinder Technology Co., Ltd., Qingdao, Shandong 266061, China
* Authors to whom correspondence should be addressed.
Received: 28 August 2012 / Revised: 7 November 2012 / Accepted: 13 November 2012 / Published: 22 November 2012
(This article belongs to the Special Issue Marine Algae)
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Abstract

This study evaluates the effects of Sargassum pallidum polysaccharides (SPP) on the immune responses in a chicken model. The adjuvanticity of Sargassum pallidum polysaccharides in Newcastle disease (ND), infectious bronchitis (IB) and avian influenza (AI) was investigated by examining the antibody titers and lymphocyte proliferation following immunization in chickens. The chickens were administrated combined ND, IB and AI inactivated vaccines containing SPP at 10, 30 and 50 mg/mL, using an oil adjuvant vaccine as a control. The ND, IB and AI antibody titers and the lymphocyte proliferation were enhanced at 30 mg/mL SPP. In conclusion, an appropriate dose of SPP may be a safe and efficacious immune stimulator candidate that is suitable for vaccines to produce early and persistent prophylaxis.
Keywords: Sargassum pallidum polysaccharide; combined Newcastle disease, infectious bronchitis and avian influenza inactivated vaccines; antibody titer; T lymphocytes Sargassum pallidum polysaccharide; combined Newcastle disease, infectious bronchitis and avian influenza inactivated vaccines; antibody titer; T lymphocytes
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Li, L.-J.; Li, M.-Y.; Li, Y.-T.; Feng, J.-J.; Hao, F.-Q.; Zhang, L. Adjuvant Activity of Sargassum pallidum Polysaccharides against Combined Newcastle Disease, Infectious Bronchitis and Avian Influenza Inactivated Vaccines. Mar. Drugs 2012, 10, 2648-2660.

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