Mar. Drugs 2012, 10(11), 2571-2583; doi:10.3390/md10112571
Article

Four New Antibacterial Xanthones from the Marine-Derived Actinomycetes Streptomyces caelestis

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Received: 20 September 2012; in revised form: 8 November 2012 / Accepted: 12 November 2012 / Published: 20 November 2012
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: Four new polycyclic antibiotics, citreamicin θ A (1), citreamicin θ B (2), citreaglycon A (3), and dehydrocitreaglycon A (4), were isolated from marine-derived Streptomyces caelestis. The structures of these compounds were elucidated by 1D and 2D NMR spectra. All four compounds displayed antibacterial activity against Staphylococcus haemolyticus, Staphylococcus aureus, and Bacillus subtillis. Citreamicin θ A (1), citreamicin θ B (2) and citreaglycon A (3) also exhibited low MIC values of 0.25, 0.25, and 8.0 μg/mL, respectively, against methicillin-resistant Staphylococcus aureus (MRSA) ATCC 43300.
Keywords: Streptomyces caelestis; citreamicin; antibacterial; MRSA
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MDPI and ACS Style

Liu, L.-L.; Xu, Y.; Han, Z.; Li, Y.-X.; Lu, L.; Lai, P.-Y.; Zhong, J.-L.; Guo, X.-R.; Zhang, X.-X.; Qian, P.-Y. Four New Antibacterial Xanthones from the Marine-Derived Actinomycetes Streptomyces caelestis. Mar. Drugs 2012, 10, 2571-2583.

AMA Style

Liu L-L, Xu Y, Han Z, Li Y-X, Lu L, Lai P-Y, Zhong J-L, Guo X-R, Zhang X-X, Qian P-Y. Four New Antibacterial Xanthones from the Marine-Derived Actinomycetes Streptomyces caelestis. Marine Drugs. 2012; 10(11):2571-2583.

Chicago/Turabian Style

Liu, Ling-Li; Xu, Ying; Han, Zhuang; Li, Yong-Xin; Lu, Liang; Lai, Pok-Yui; Zhong, Jia-Liang; Guo, Xian-Rong; Zhang, Xi-Xiang; Qian, Pei-Yuan. 2012. "Four New Antibacterial Xanthones from the Marine-Derived Actinomycetes Streptomyces caelestis." Mar. Drugs 10, no. 11: 2571-2583.

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