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Mar. Drugs 2012, 10(11), 2571-2583; doi:10.3390/md10112571
Article

Four New Antibacterial Xanthones from the Marine-Derived Actinomycetes Streptomyces caelestis

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1 Division of Life Science, The Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong SAR, China 2 Shanghai Institute of Pharmaceutical Industry, Shanghai 200040, China 3 Advanced Nano-Fabrication, Imaging and Characterization Core Lab, King Abdullah University of Science and Technology, Thuwal 23955-6900, Saudi Arabia
* Author to whom correspondence should be addressed.
Received: 20 September 2012 / Revised: 8 November 2012 / Accepted: 12 November 2012 / Published: 20 November 2012
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Abstract

Four new polycyclic antibiotics, citreamicin θ A (1), citreamicin θ B (2), citreaglycon A (3), and dehydrocitreaglycon A (4), were isolated from marine-derived Streptomyces caelestis. The structures of these compounds were elucidated by 1D and 2D NMR spectra. All four compounds displayed antibacterial activity against Staphylococcus haemolyticus, Staphylococcus aureus, and Bacillus subtillis. Citreamicin θ A (1), citreamicin θ B (2) and citreaglycon A (3) also exhibited low MIC values of 0.25, 0.25, and 8.0 μg/mL, respectively, against methicillin-resistant Staphylococcus aureus (MRSA) ATCC 43300.
Keywords: Streptomyces caelestis; citreamicin; antibacterial; MRSA Streptomyces caelestis; citreamicin; antibacterial; MRSA
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Liu, L.-L.; Xu, Y.; Han, Z.; Li, Y.-X.; Lu, L.; Lai, P.-Y.; Zhong, J.-L.; Guo, X.-R.; Zhang, X.-X.; Qian, P.-Y. Four New Antibacterial Xanthones from the Marine-Derived Actinomycetes Streptomyces caelestis. Mar. Drugs 2012, 10, 2571-2583.

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