Mar. Drugs 2012, 10(11), 2571-2583; doi:10.3390/md10112571
Article

Four New Antibacterial Xanthones from the Marine-Derived Actinomycetes Streptomyces caelestis

Ling-Li Liu 1 email, Ying Xu 1 email, Zhuang Han 1 email, Yong-Xin Li 1 email, Liang Lu 1 email, Pok-Yui Lai 1 email, Jia-Liang Zhong 2 email, Xian-Rong Guo 3 email, Xi-Xiang Zhang 3 email and Pei-Yuan Qian 1,* email
1 Division of Life Science, The Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong SAR, China 2 Shanghai Institute of Pharmaceutical Industry, Shanghai 200040, China 3 Advanced Nano-Fabrication, Imaging and Characterization Core Lab, King Abdullah University of Science and Technology, Thuwal 23955-6900, Saudi Arabia
* Author to whom correspondence should be addressed.
Received: 20 September 2012; in revised form: 8 November 2012 / Accepted: 12 November 2012 / Published: 20 November 2012
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Abstract: Four new polycyclic antibiotics, citreamicin θ A (1), citreamicin θ B (2), citreaglycon A (3), and dehydrocitreaglycon A (4), were isolated from marine-derived Streptomyces caelestis. The structures of these compounds were elucidated by 1D and 2D NMR spectra. All four compounds displayed antibacterial activity against Staphylococcus haemolyticus, Staphylococcus aureus, and Bacillus subtillis. Citreamicin θ A (1), citreamicin θ B (2) and citreaglycon A (3) also exhibited low MIC values of 0.25, 0.25, and 8.0 μg/mL, respectively, against methicillin-resistant Staphylococcus aureus (MRSA) ATCC 43300.
Keywords: Streptomyces caelestis; citreamicin; antibacterial; MRSA

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Cite This Article

MDPI and ACS Style

Liu, L.-L.; Xu, Y.; Han, Z.; Li, Y.-X.; Lu, L.; Lai, P.-Y.; Zhong, J.-L.; Guo, X.-R.; Zhang, X.-X.; Qian, P.-Y. Four New Antibacterial Xanthones from the Marine-Derived Actinomycetes Streptomyces caelestis. Mar. Drugs 2012, 10, 2571-2583.

AMA Style

Liu L-L, Xu Y, Han Z, Li Y-X, Lu L, Lai P-Y, Zhong J-L, Guo X-R, Zhang X-X, Qian P-Y. Four New Antibacterial Xanthones from the Marine-Derived Actinomycetes Streptomyces caelestis. Marine Drugs. 2012; 10(11):2571-2583.

Chicago/Turabian Style

Liu, Ling-Li; Xu, Ying; Han, Zhuang; Li, Yong-Xin; Lu, Liang; Lai, Pok-Yui; Zhong, Jia-Liang; Guo, Xian-Rong; Zhang, Xi-Xiang; Qian, Pei-Yuan. 2012. "Four New Antibacterial Xanthones from the Marine-Derived Actinomycetes Streptomyces caelestis." Mar. Drugs 10, no. 11: 2571-2583.

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