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New Capoamycin-Type Antibiotics and Polyene Acids from Marine Streptomyces fradiae PTZ0025
College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China
Department of Ocean Science and Engineering, Zhejiang University, Hangzhou 310058, China
* Authors to whom correspondence should be addressed.
Received: 4 September 2012; in revised form: 8 October 2012 / Accepted: 12 October 2012 / Published: 29 October 2012
Abstract: Capoamycin-type antibiotics (2–5) and polyene acids (6, 7) were isolated from marine Streptomyces fradiae strain PTZ0025. Their structures were established by extensive nuclear magnetic resonance (NMR) and high resolution electron spray ionization mass spectroscopy (HRESIMS) analyses and chemical degradation. Compounds 3, 4, 6, 7 were found to be new and named as fradimycins A (3) and B (4), and fradic acids A (6) and B (7). Compounds 3–5 showed in vitro antimicrobial activity against Staphylococcus aureus with a minimal inhibitory concentration (MIC) of 2.0 to 6.0 μg/mL. Interestingly, Compounds 3–5 also significantly inhibited cell growth of colon cancer and glioma with IC50 values ranging from 0.13 to 6.46 μM. Fradimycin B (4), the most active compound, was further determined to arrest cell cycle and induce apoptosis in tumor cells. The results indicated that fradimycin B (4) arrested the cell cycle at the G0/G1 phase and induced apoptosis and necrosis in colon cancer and glioma cells. Taken together, the results demonstrated that the marine natural products 3–5, particularly fradimycin B (4), possessed potent antimicrobial and antitumor activities.
Keywords: marine Streptomyces fradiae; fradimycins A and B; fradic acids A and B; antibacterial and antitumor activities
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MDPI and ACS Style
Xin, W.; Ye, X.; Yu, S.; Lian, X.-Y.; Zhang, Z. New Capoamycin-Type Antibiotics and Polyene Acids from Marine Streptomyces fradiae PTZ0025. Mar. Drugs 2012, 10, 2388-2402.
Xin W, Ye X, Yu S, Lian X-Y, Zhang Z. New Capoamycin-Type Antibiotics and Polyene Acids from Marine Streptomyces fradiae PTZ0025. Marine Drugs. 2012; 10(11):2388-2402.
Xin, Wenxiu; Ye, Xuewei; Yu, Siran; Lian, Xiao-Yuan; Zhang, Zhizhen. 2012. "New Capoamycin-Type Antibiotics and Polyene Acids from Marine Streptomyces fradiae PTZ0025." Mar. Drugs 10, no. 11: 2388-2402.