Mar. Drugs 2012, 10(11), 2388-2402; doi:10.3390/md10112388
Article

New Capoamycin-Type Antibiotics and Polyene Acids from Marine Streptomyces fradiae PTZ0025

1 College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China 2 Department of Ocean Science and Engineering, Zhejiang University, Hangzhou 310058, China
* Authors to whom correspondence should be addressed.
Received: 4 September 2012; in revised form: 8 October 2012 / Accepted: 12 October 2012 / Published: 29 October 2012
PDF Full-text Download PDF Full-Text [885 KB, uploaded 29 October 2012 14:13 CET]
Abstract: Capoamycin-type antibiotics (25) and polyene acids (6, 7) were isolated from marine Streptomyces fradiae strain PTZ0025. Their structures were established by extensive nuclear magnetic resonance (NMR) and high resolution electron spray ionization mass spectroscopy (HRESIMS) analyses and chemical degradation. Compounds 3, 4, 6, 7 were found to be new and named as fradimycins A (3) and B (4), and fradic acids A (6) and B (7). Compounds 35 showed in vitro antimicrobial activity against Staphylococcus aureus with a minimal inhibitory concentration (MIC) of 2.0 to 6.0 μg/mL. Interestingly, Compounds 35 also significantly inhibited cell growth of colon cancer and glioma with IC50 values ranging from 0.13 to 6.46 μM. Fradimycin B (4), the most active compound, was further determined to arrest cell cycle and induce apoptosis in tumor cells. The results indicated that fradimycin B (4) arrested the cell cycle at the G0/G1 phase and induced apoptosis and necrosis in colon cancer and glioma cells. Taken together, the results demonstrated that the marine natural products 35, particularly fradimycin B (4), possessed potent antimicrobial and antitumor activities.
Keywords: marine Streptomyces fradiae; fradimycins A and B; fradic acids A and B; antibacterial and antitumor activities

Supplementary Files

Article Statistics

Load and display the download statistics.

Citations to this Article

Cite This Article

MDPI and ACS Style

Xin, W.; Ye, X.; Yu, S.; Lian, X.-Y.; Zhang, Z. New Capoamycin-Type Antibiotics and Polyene Acids from Marine Streptomyces fradiae PTZ0025. Mar. Drugs 2012, 10, 2388-2402.

AMA Style

Xin W, Ye X, Yu S, Lian X-Y, Zhang Z. New Capoamycin-Type Antibiotics and Polyene Acids from Marine Streptomyces fradiae PTZ0025. Marine Drugs. 2012; 10(11):2388-2402.

Chicago/Turabian Style

Xin, Wenxiu; Ye, Xuewei; Yu, Siran; Lian, Xiao-Yuan; Zhang, Zhizhen. 2012. "New Capoamycin-Type Antibiotics and Polyene Acids from Marine Streptomyces fradiae PTZ0025." Mar. Drugs 10, no. 11: 2388-2402.

Mar. Drugs EISSN 1660-3397 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert