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Mar. Drugs 2012, 10(1), 64-83; doi:10.3390/md10010064
Article

Marine Compounds Selectively Induce Apoptosis in Female Reproductive Cancer Cells but Not in Primary-Derived Human Reproductive Granulosa Cells

1
, 2,3,*  and 1
Received: 16 November 2011; in revised form: 19 December 2011 / Accepted: 30 December 2011 / Published: 10 January 2012
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Abstract: Anticancer properties of tyrindoleninone and 6-bromoisatin from Dicathais orbita were tested against physiologically normal primary human granulosa cells (HGC) and reproductive cancer cell lines. Tyrindoleninone reduced cancer cell viability with IC50 values of 39 µM (KGN; a tumour-derived granulosa cell line), 39 μM (JAr), and 156 μM (OVCAR-3), compared to 3516 μM in HGC. Apoptosis in HGC’s occurred after 4 h at 391 µM tyrindoleninone compared to 20 µM in KGN cells. Differences in apoptosis between HGC and KGN cells were confirmed by TUNEL, with 66 and 31% apoptotic nuclei at 4 h in KGN and HGC, respectively. These marine compounds therefore have potential for development as treatments for female reproductive cancers.
Keywords: gynaecological cancers; brominated indoles; marine mollusc; apoptosis gynaecological cancers; brominated indoles; marine mollusc; apoptosis
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Edwards, V.; Benkendorff, K.; Young, F. Marine Compounds Selectively Induce Apoptosis in Female Reproductive Cancer Cells but Not in Primary-Derived Human Reproductive Granulosa Cells. Mar. Drugs 2012, 10, 64-83.

AMA Style

Edwards V, Benkendorff K, Young F. Marine Compounds Selectively Induce Apoptosis in Female Reproductive Cancer Cells but Not in Primary-Derived Human Reproductive Granulosa Cells. Marine Drugs. 2012; 10(1):64-83.

Chicago/Turabian Style

Edwards, Vicki; Benkendorff, Kirsten; Young, Fiona. 2012. "Marine Compounds Selectively Induce Apoptosis in Female Reproductive Cancer Cells but Not in Primary-Derived Human Reproductive Granulosa Cells." Mar. Drugs 10, no. 1: 64-83.



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