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Mar. Drugs 2012, 10(1), 209-222; doi:10.3390/md10010209
Article

Bioactive Hydroperoxyl Cembranoids from the Red Sea Soft Coral Sarcophyton glaucum

1
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Received: 28 November 2011; in revised form: 5 January 2012 / Accepted: 9 January 2012 / Published: 18 January 2012
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Abstract: A chemical investigation of an ethyl acetate extract of the Red Sea soft coral Sarcophyton glaucum has led to the isolation of two peroxide diterpenes, 11(S) hydroperoxylsarcoph-12(20)-ene (1), and 12(S)-hydroperoxylsarcoph-10-ene (2), as well as 8-epi-sarcophinone (3). In addition to these three new compounds, two known structures were identified including: ent-sarcophine (4) and sarcophine (5). Structures were elucidated by spectroscopic analysis, with the relative configuration of 1 and 2 confirmed by X-ray diffraction. Isolated compounds were found to be inhibitors of cytochrome P450 1A activity as well as inducers of glutathione S-transferases (GST), quinone reductase (QR), and epoxide hydrolase (mEH) establishing chemo-preventive and tumor anti-initiating activity for these characterized metabolites.
Keywords: Sarcophyton glaucum; soft coral; diterpenes; cancer chemo-preventive activity Sarcophyton glaucum; soft coral; diterpenes; cancer chemo-preventive activity
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Hegazy, M.-E.; Eldeen, A.M.G.; Shahat, A.A.; Abdel-Latif, F.F.; Mohamed, T.A.; Whittlesey, B.R.; Paré, P.W. Bioactive Hydroperoxyl Cembranoids from the Red Sea Soft Coral Sarcophyton glaucum. Mar. Drugs 2012, 10, 209-222.

AMA Style

Hegazy M-E, Eldeen AMG, Shahat AA, Abdel-Latif FF, Mohamed TA, Whittlesey BR, Paré PW. Bioactive Hydroperoxyl Cembranoids from the Red Sea Soft Coral Sarcophyton glaucum. Marine Drugs. 2012; 10(1):209-222.

Chicago/Turabian Style

Hegazy, Mohamed-Elamir F.; Eldeen, Amira M. Gamal; Shahat, Abdelaaty A.; Abdel-Latif, Fathy F.; Mohamed, Tarik A.; Whittlesey, Bruce R.; Paré, Paul W. 2012. "Bioactive Hydroperoxyl Cembranoids from the Red Sea Soft Coral Sarcophyton glaucum." Mar. Drugs 10, no. 1: 209-222.



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