Bioactive Hydroperoxyl Cembranoids from the Red Sea Soft Coral Sarcophyton glaucum
AbstractA chemical investigation of an ethyl acetate extract of the Red Sea soft coral Sarcophyton glaucum has led to the isolation of two peroxide diterpenes, 11(S) hydroperoxylsarcoph-12(20)-ene (1), and 12(S)-hydroperoxylsarcoph-10-ene (2), as well as 8-epi-sarcophinone (3). In addition to these three new compounds, two known structures were identified including: ent-sarcophine (4) and sarcophine (5). Structures were elucidated by spectroscopic analysis, with the relative configuration of 1 and 2 confirmed by X-ray diffraction. Isolated compounds were found to be inhibitors of cytochrome P450 1A activity as well as inducers of glutathione S-transferases (GST), quinone reductase (QR), and epoxide hydrolase (mEH) establishing chemo-preventive and tumor anti-initiating activity for these characterized metabolites.
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Hegazy, M.-E.; Eldeen, A.M.G.; Shahat, A.A.; Abdel-Latif, F.F.; Mohamed, T.A.; Whittlesey, B.R.; Paré, P.W. Bioactive Hydroperoxyl Cembranoids from the Red Sea Soft Coral Sarcophyton glaucum. Mar. Drugs 2012, 10, 209-222.
Hegazy M-E, Eldeen AMG, Shahat AA, Abdel-Latif FF, Mohamed TA, Whittlesey BR, Paré PW. Bioactive Hydroperoxyl Cembranoids from the Red Sea Soft Coral Sarcophyton glaucum. Marine Drugs. 2012; 10(1):209-222.Chicago/Turabian Style
Hegazy, Mohamed-Elamir F.; Eldeen, Amira M. Gamal; Shahat, Abdelaaty A.; Abdel-Latif, Fathy F.; Mohamed, Tarik A.; Whittlesey, Bruce R.; Paré, Paul W. 2012. "Bioactive Hydroperoxyl Cembranoids from the Red Sea Soft Coral Sarcophyton glaucum." Mar. Drugs 10, no. 1: 209-222.