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Mar. Drugs 2012, 10(1), 209-222; doi:10.3390/md10010209

Bioactive Hydroperoxyl Cembranoids from the Red Sea Soft Coral Sarcophyton glaucum

Chemistry of Medicinal Plants Department, and Center of Excellence for Advanced Sciences, National Research Centre, El-Tahrir Street, Dokki, Giza 12622, Egypt
Cancer Biology Lab, Center of Excellence for Advanced Sciences, and Biochemistry Department, National Research Center, Dokki Cairo 12622, Egypt
Medicinal, Aromatic and Poisonous Plants Research Center, College of Pharmacy, King Saudi University, PO Box 2457, Riyadh 11451, Saudi Arabia
Department of Chemistry, Faculty of Science, Minia University, El-Minia 61519, Egypt
Department of Chemistry and Biochemistry, Texas Tech University, Lubbock, TX 79409, USA
Author to whom correspondence should be addressed.
Received: 28 November 2011 / Revised: 5 January 2012 / Accepted: 9 January 2012 / Published: 18 January 2012
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A chemical investigation of an ethyl acetate extract of the Red Sea soft coral Sarcophyton glaucum has led to the isolation of two peroxide diterpenes, 11(S) hydroperoxylsarcoph-12(20)-ene (1), and 12(S)-hydroperoxylsarcoph-10-ene (2), as well as 8-epi-sarcophinone (3). In addition to these three new compounds, two known structures were identified including: ent-sarcophine (4) and sarcophine (5). Structures were elucidated by spectroscopic analysis, with the relative configuration of 1 and 2 confirmed by X-ray diffraction. Isolated compounds were found to be inhibitors of cytochrome P450 1A activity as well as inducers of glutathione S-transferases (GST), quinone reductase (QR), and epoxide hydrolase (mEH) establishing chemo-preventive and tumor anti-initiating activity for these characterized metabolites.
Keywords: Sarcophyton glaucum; soft coral; diterpenes; cancer chemo-preventive activity Sarcophyton glaucum; soft coral; diterpenes; cancer chemo-preventive activity
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Hegazy, M.-E.; Eldeen, A.M.G.; Shahat, A.A.; Abdel-Latif, F.F.; Mohamed, T.A.; Whittlesey, B.R.; Paré, P.W. Bioactive Hydroperoxyl Cembranoids from the Red Sea Soft Coral Sarcophyton glaucum. Mar. Drugs 2012, 10, 209-222.

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