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Mar. Drugs 2012, 10(1), 200-208; doi:10.3390/md10010200
Article

Aurantoside K, a New Antifungal Tetramic Acid Glycoside from a Fijian Marine Sponge of the Genus Melophlus

,
* ,
 and
Centre for Drug Discovery and Conservation, Institute of Applied Sciences, The University of the South Pacific, Suva, Fiji Islands
* Author to whom correspondence should be addressed.
Received: 13 December 2011 / Revised: 11 January 2012 / Accepted: 13 January 2012 / Published: 18 January 2012
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Abstract

A new tetramic acid glycoside, aurantoside K, was isolated from a marine sponge belonging to the genus Melophlus. The structure of the compound was elucidated on the basis of spectroscopic analysis (1H NMR, 1H–1H COSY, HSQC, and HMBC, as well as high-resolution ESILCMS). Aurantoside K did not show any significant activity in antimalarial, antibacterial, or HCT-116 cytotoxicity assays, but exhibited a wide spectrum of antifungal activity against wild type Candida albicans, amphotericin-resistant C. albicans, Cryptococcus neoformans, Aspergillus niger, Penicillium sp., Rhizopus sporangia and Sordaria sp.
Keywords: marine sponges; aurantosides; antifungal; tetramic acid glycoside; Melophlus sp. marine sponges; aurantosides; antifungal; tetramic acid glycoside; Melophlus sp.
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Kumar, R.; Subramani, R.; Feussner, K.-D.; Aalbersberg, W. Aurantoside K, a New Antifungal Tetramic Acid Glycoside from a Fijian Marine Sponge of the Genus Melophlus. Mar. Drugs 2012, 10, 200-208.

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