Mar. Drugs 2003, 1(1), 18-26; doi:10.3390/md101018
Article

13-Epi-9-deacetoxyxenicin, a Cytotoxic Diterpene from the Soft Coral Asterospicularia laurae (Alcyonacea)

Bruce F. Bowden* email, Bernard J. Cusack and Alissa Dangel
Department of Chemistry, School of Pharmacy and Molecular Sciences, James Cook University, Townsville, Qld., 4811, Australia
* Author to whom correspondence should be addressed.
Received: 14 February 2003 / Accepted: 16 October 2003 / Published: 15 November 2003
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Abstract: An investigation of the soft coral Asterospicularia laurae collected on the Great Barrier Reef, Australia, afforded the cytotoxic diterpene 13-epi-9-deacetoxyxenicin (1) in addition to the known metabolites 13-epi-9-deacetylxenicin (2) and gorgosterol. 13-Epi-9-deacetoxyxenicin readily underwent an autoxidation reaction in solution to afford a single product, the hydroperoxide 3. Structures, stereochemistry, and NMR assignments were established by high resolution NMR spectroscopy and by comparison with published data for known compounds.
Keywords: Cytotoxic; xenicane diterpene; soft coral; Asterospicularia

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MDPI and ACS Style

Bowden, B.F.; Cusack, B.J.; Dangel, A. 13-Epi-9-deacetoxyxenicin, a Cytotoxic Diterpene from the Soft Coral Asterospicularia laurae (Alcyonacea). Mar. Drugs 2003, 1, 18-26.

AMA Style

Bowden BF, Cusack BJ, Dangel A. 13-Epi-9-deacetoxyxenicin, a Cytotoxic Diterpene from the Soft Coral Asterospicularia laurae (Alcyonacea). Marine Drugs. 2003; 1(1):18-26.

Chicago/Turabian Style

Bowden, Bruce F.; Cusack, Bernard J.; Dangel, Alissa. 2003. "13-Epi-9-deacetoxyxenicin, a Cytotoxic Diterpene from the Soft Coral Asterospicularia laurae (Alcyonacea)." Mar. Drugs 1, no. 1: 18-26.

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