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Pharmaceuticals 2016, 9(4), 78; doi:10.3390/ph9040078

Use of Aptamers as Diagnostics Tools and Antiviral Agents for Human Viruses

1
Departamento de Bioquímica-Investigación, Instituto Ramón y Cajal de Investigación Sanitaria (IRYCIS)-Hospital Ramón y Cajal, 28034 Madrid, Spain
2
Aptus Biotech SL, c/Faraday, 7, Parque Científico de Madrid, Campus de Cantoblanco, 28049 Madrid, Spain
*
Author to whom correspondence should be addressed.
Academic Editors: Cristina Romero-López and Alfredo Berzal-Herranz
Received: 13 October 2016 / Revised: 12 December 2016 / Accepted: 13 December 2016 / Published: 16 December 2016
(This article belongs to the Special Issue Aptamers: Biomedical Interest and Applications)
View Full-Text   |   Download PDF [2053 KB, uploaded 16 December 2016]   |  

Abstract

Appropriate diagnosis is the key factor for treatment of viral diseases. Time is the most important factor in rapidly developing and epidemiologically dangerous diseases, such as influenza, Ebola and SARS. Chronic viral diseases such as HIV-1 or HCV are asymptomatic or oligosymptomatic and the therapeutic success mainly depends on early detection of the infective agent. Over the last years, aptamer technology has been used in a wide range of diagnostic and therapeutic applications and, concretely, several strategies are currently being explored using aptamers against virus proteins. From a diagnostics point of view, aptamers are being designed as a bio-recognition element in diagnostic systems to detect viral proteins either in the blood (serum or plasma) or into infected cells. Another potential use of aptamers is for therapeutics of viral infections, interfering in the interaction between the virus and the host using aptamers targeting host-cell matrix receptors, or attacking the virus intracellularly, targeting proteins implicated in the viral replication cycle. In this paper, we review how aptamers working against viral proteins are discovered, with a focus on recent advances that improve the aptamers’ properties as a real tool for viral infection detection and treatment. View Full-Text
Keywords: aptamer; diagnosis; ebola; HBV; HCV; HIV; influenza; SELEX; therapeutic; virus aptamer; diagnosis; ebola; HBV; HCV; HIV; influenza; SELEX; therapeutic; virus
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MDPI and ACS Style

González, V.M.; Martín, M.E.; Fernández, G.; García-Sacristán, A. Use of Aptamers as Diagnostics Tools and Antiviral Agents for Human Viruses. Pharmaceuticals 2016, 9, 78.

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