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Pharmaceuticals 2016, 9(3), 34; doi:10.3390/ph9030034

Relationship between Surface Properties and In Vitro Drug Release from a Compressed Matrix Containing an Amphiphilic Polymer Material

Pharmaceutical Physical Chemistry Laboratory, Natura Research Group, Pharmaceutical Chemistry Program, Faculty of Natural Sciences, ICESI University, Cali 760031, Colombia
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Academic Editor: Thomas Rades
Received: 7 March 2016 / Revised: 3 June 2016 / Accepted: 20 June 2016 / Published: 24 June 2016
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Abstract

The performance of compressed tablet drug delivery systems made using polymeric materials depend on multiple factors, such as surface properties like contact angle, surface free energy and water absorption rate, besides the release mechanisms driven by the kind of polymer used. Hence, it should be possible to establish a relationship between the surface properties and the drug release kinetics. Compressed tablets with different proportions of poly(maleic acid-alt-octadecene) potassium salt (0%, 10%, 20%, 30% and 40%) were prepared. Blends of a model drug (ampicillin trihydrate) and the polymer material were analyzed by DSC. The surface properties of the tablets were determined by the sessile drop method, while the surface energy was determined using the semi-empirical Young-Dupre, Neumann and OWRK models. The release profiles were determined simulating in vitro conditions (buffer solutions pH 1.2 and pH 7.4 with ionic strength of 1.5 M at 37 °C (310.15 K)). A kinetic analysis of the dissolution profiles using different models (zero order, first order, Higuchi and Korsmeyer-Peppas) was realized. The results showed a significant effect of the proportion of polymer in both the surface properties of the tablets and the dissolution release, indicating a relationship between the kinetic and thermodynamic properties. View Full-Text
Keywords: surface free energy; surface properties; drug release; amphiphilic polymer surface free energy; surface properties; drug release; amphiphilic polymer
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MDPI and ACS Style

Yarce, C.J.; Pineda, D.; Correa, C.E.; Salamanca, C.H. Relationship between Surface Properties and In Vitro Drug Release from a Compressed Matrix Containing an Amphiphilic Polymer Material. Pharmaceuticals 2016, 9, 34.

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