Next Article in Journal
UCP2 Modulates Cardioprotective Effects of Ru360 in Isolated Cardiomyocytes during Ischemia
Previous Article in Journal
Bench to Bedside: Stability Studies of GMP Produced Trastuzumab-TCMC in Support of a Clinical Trial
Article Menu

Export Article

Open AccessReview
Pharmaceuticals 2015, 8(3), 455-473; doi:10.3390/ph8030455

On the Quest of Cellular Functions of PEA-15 and the Therapeutic Opportunities

1
Department of Chemistry, New Jersery City University, 2039 Kennedy Blvd, Jersey City, NJ 07305, USA
2
Institute of NeuroImmune Pharmacology, Seton Hall University, 400 South Orange Ave, South Orange, NJ 07094, USA 
Academic Editor: Jean Jacques Vanden Eynde
Received: 1 April 2015 / Revised: 18 July 2015 / Accepted: 24 July 2015 / Published: 31 July 2015
View Full-Text   |   Download PDF [437 KB, uploaded 31 July 2015]   |  

Abstract

Phosphoprotein enriched in astrocytes, 15 KDa (PEA-15), a ubiquitously expressed small protein in all mammals, is known for decades for its potent interactions with various protein partners along distinct biological pathways. Most notable interacting partners of PEA-15 include extracellular signal-regulated kinase 1 and 2 (ERK1/2) in the mitogen activated protein kinase (MAPK) pathway, the Fas-associated death domain (FADD) protein involving in the formation of the death-inducing signaling complex (DISC), and the phospholipase D1 (PLD1) affecting the insulin sensitivity. However, the actual cellular functions of PEA-15 are still mysterious, and the question why this protein is expressed in almost all cell and tissue types remains unanswered. Here we synthesize the most recent structural, biological, and clinical studies on PEA-15 with emphases on its anti-apoptotic, anti-proliferative, and anti-inflammative properties, and propose a converged protective role of PEA-15 that maintains the balance of death and survival in different cell types. Under conditions that this delicate balance is unsustainable, PEA-15 may become pathological and lead to various diseases, including cancers and diabetes. Targeting PEA-15 interactions, or the use of PEA-15 protein as therapeutics, may provide a wider window of opportunities to treat these diseases. View Full-Text
Keywords: PEA-15; MAP kinase; apoptosis; phosphorylation; protein-protein interaction PEA-15; MAP kinase; apoptosis; phosphorylation; protein-protein interaction
Figures

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Wei, Y. On the Quest of Cellular Functions of PEA-15 and the Therapeutic Opportunities. Pharmaceuticals 2015, 8, 455-473.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Pharmaceuticals EISSN 1424-8247 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top